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Suppression of herpes simplex virus type 1 reactivation from latency by (+-)-9-([(Z)-2-(hydroxymethyl)cyclohexyl]methyl) guanine (L-653,180) in vitro

Autor: Y A Nsiah, J D Karkas, F Rapp, R L Tolman

Publikováno v: Antimicrobial Agents and Chemotherapy. 34:1551-1555

Latent herpes simplex virus type 1 (HSV-1) infection was induced in human embryonic lung cells in vitro by using a combination of viral replication inhibitors and elevated temperature. Under reactivating conditions (superinfection by human cytomegalo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc26282cd387ab1684aed5ac7cb20104
https://doi.org/10.1128/aac.34.8.1551

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Evaluation of retinal toxicity and liposome encapsulation of the anti-CMV drug 2'-nor-cyclic GMP

Autor: S, Shakiba, K K, Assil, A D, Listhaus, D, Munguia, M, Flores-Aguilar, C, Vuong, C A, Wiley, R L, Tolman, J D, Karkas, G, Bergeron-Lynn

Publikováno v: Investigative ophthalmologyvisual science. 34(10)

Human cytomegalovirus (HCMV) is an important pathogen in the immunocompromised patient. CMV retinitis is a leading cause of blindness in patients with AIDS. Ganciclovir and foscarnet are currently the treatments being used for this retinitis, but the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4567646b61f20cf2f8739f95f0a0f638
https://pubmed.ncbi.nlm.nih.gov/8395482

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Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase

Autor: Vanmiddlesworth Frank L, Deborah J. Rew, James D. Bergstrom, Otto D. Hensens, J D Karkas, V S Bansal, Richard G. Bostedor, Marc M. Kurtz, Claude Dufresne, A M Amend

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 90(1)

Three closely related fungal metabolites, zaragozic acids A, B, and C, that are potent inhibitors of squalene synthase have been isolated and characterized. Zaragozic acids A, B, and C were produced from an unidentified sterile fungal culture, Sporor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd62ae43f484c7c769800eecf35102ac
https://pubmed.ncbi.nlm.nih.gov/8419946

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Lowering of plasma cholesterol levels in animals by lovastatin and simvastatin

Autor: Y, Chao, J S, Chen, V M, Hunt, G W, Kuron, J D, Karkas, R, Liou, A W, Alberts

Publikováno v: European journal of clinical pharmacology. 40

Lovastatin and simvastatin are potent competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Key inhibit the synthesis of cholesterol in cultured HepG23 cells, rat hepatocytes and in rats. The primary target organ of cholesterol s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::67c835a87ae5fa8daabd0be46c872944
https://pubmed.ncbi.nlm.nih.gov/2044637

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A DNA polymerase from embryos of Drosophila melanogaster. Purification and properties

Autor: J D Karkas, L Margulies, Erwin Chargaff

Publikováno v: Journal of Biological Chemistry. 250:8657-8663

The more than 2,300-fold purification of a DNA polymerase from the embryos of Drosophila melanogaster is described. The enzyme, which forms a single band on gel electrophoresis, has a molecular weight of about 87,000 and a pH optimum of 8.5. A divale

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::faf21027ddfc5682fa51a779b4797dfd
https://doi.org/10.1016/s0021-9258(19)40721-7

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A DNA polymerase from embryos of Drosophila melanogaster. Purification and properties

Autor: J D, Karkas, L, Margulies, E, Chargaff

Publikováno v: The Journal of biological chemistry. 250(22)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::646bd5e27aa27ef1e82c9186d03447c5
https://pubmed.ncbi.nlm.nih.gov/241752

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