Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models

Autor: Michael J. D. Daniels, Jack Rivers-Auty, Tom Schilling, Nicholas G. Spencer, William Watremez, Victoria Fasolino, Sophie J. Booth, Claire S. White, Alex G. Baldwin, Sally Freeman, Raymond Wong, Clare Latta, Shi Yu, Joshua Jackson, Nicolas Fischer, Violette Koziel, Thierry Pillot, James Bagnall, Stuart M. Allan, Pawel Paszek, James Galea, Michael K. Harte, Claudia Eder, Catherine B. Lawrence, David Brough

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)

NSAID-induced analgesia is typically induced by inhibition of COX enzymes. Here the authors show instead that fenamate NSAIDs inhibit the Nlrp3 inflammasome via an effect on volume-regulated anion channel function and also repurpose these drugs for t

Externí odkaz: https://doaj.org/article/dca8360eb57c4ee588985f6c192c8a0c

Treatment with IgM-enriched intravenous immunoglobulins enhances clearance of stroke-associated bacterial lung infection

Autor: Laura McCulloch, Alison J. Harris, Alexandra Malbon, Michael J. D. Daniels, Mehwish Younas, John R. Grainger, Stuart M. Allan, Craig J. Smith, Barry W. McColl

Publikováno v: McCulloch, L, Harris, A, Malbon, A, Daniels, M, Younas, M, Grainger, J R, Allan, S M, Smith, C J & McColl, B W 2022, ' Treatment with IgM-enriched intravenous immunoglobulins (IgM-IVIg) enhances clearance of stroke-associated bacterial lung infection ', Immunology . https://doi.org/10.1111/imm.13553

Post-stroke infection is a common complication of stroke that is associated with increased mortality and morbidity. We previously found that experimental stroke induces an ablation of multiple sub-populations of B cells and reduced levels of IgM anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16231b6d3168b753e6e4fb844f158e3f
https://pubmed.ncbi.nlm.nih.gov/35881080

The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes

Autor: Victor S, Tapia, Michael J D, Daniels, Pablo, Palazón-Riquelme, Matthew, Dewhurst, Nadia M, Luheshi, Jack, Rivers-Auty, Jack, Green, Elena, Redondo-Castro, Philipp, Kaldis, Gloria, Lopez-Castejon, David, Brough

Publikováno v: The Journal of Biological Chemistry

Interleukin (IL)-1 family cytokines potently regulate inflammation, with the majority of the IL-1 family proteins being secreted from immune cells via unconventional pathways. In many cases, secretion of IL-1 cytokines appears to be closely coupled t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4bc970a802f25a9a3aae02c018dda128
https://pubmed.ncbi.nlm.nih.gov/30940725

Unconventional Pathways of Secretion Contribute to Inflammation

Autor: Michael J D, Daniels, David, Brough

Publikováno v: International Journal of Molecular Sciences

In the conventional pathway of protein secretion, leader sequence-containing proteins leave the cell following processing through the endoplasmic reticulum (ER) and Golgi body. However, leaderless proteins also enter the extracellular space through m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9cbd710c10695e4f5905097025d28a1c
https://pubmed.ncbi.nlm.nih.gov/28067797

Deubiquitylase USP52 Promotes Bladder Cancer Progression by Modulating Ferroptosis through Stabilizing SLC7A11/xCT.

Autor: Liu, Jianmin¹ (AUTHOR), Luo, Yongwen¹ (AUTHOR), Chen, Siming¹ (AUTHOR), Wang, Gang^1,2 (AUTHOR), Jin, Wan^2,3,4 (AUTHOR), Jiang, Wenyu¹ (AUTHOR), Li, Mingxing¹ (AUTHOR), Wang, Yejinpeng¹ (AUTHOR), Yu, Jingtian¹ (AUTHOR), Wei, Houyi¹ (AUTHOR), Zhang, Renjie¹ (AUTHOR), Zhou, Fenfang^1,5 (AUTHOR), Ju, Lingao^1,2 (AUTHOR), Zhang, Yi^2,4 (AUTHOR), Xiao, Yu^2,3 (AUTHOR), Qian, Kaiyu² (AUTHOR) qky1009@whu.edu.cn, Wang, Xinghuan^1,6,7 (AUTHOR) wangxinghuan@whu.edu.cn

Publikováno v: Advanced Science. 12/4/2024, Vol. 11 Issue 45, p1-19. 19p.