Zobrazeno 1 - 10 of 38 pro vyhledávání: '"J D Broome"'
1
Epigenetic changes in the repression and induction of asparagine synthetase in human leukemic cell lines
Autor: Y Ding, J D Broome, Z Li
Publikováno v: Leukemia. 19:420-426
In common with certain other lymphoid neoplasms, cells of the human lymphocytic leukemia lines 1873 and 1929 are asparagine (ASN) auxotrophs. Asparagine synthetase (ASY), which is a housekeeping gene, is repressed and the promoting region of the gene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a687692ab9312bd781f6d78c21db109a
https://doi.org/10.1038/sj.leu.2403639
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2
Deletion of cyclin-dependent kinase 4 inhibitor genes P15 and P16 in non-Hodgkin's lymphoma
Autor: Prasad Koduru, Jerald Z. Gong, M. Soni, M. Zariwala, J. D. Broome, Y. Xiong
Publikováno v: Blood. 86:2900-2905
B-cell non-Hodgkin's lymphoma (NHL) is a heterogeneous lymphoid malignancy consisting of several histologic types. Alterations in proto-oncogenes caused by reciprocal chromosome translocations have been implicated in the etiology of specific histolog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::192c8ecc54d282dfd7216a5949eefef8
https://doi.org/10.1182/blood.v86.8.2900.bloodjournal8682900
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3
THE ANTICOAGULANT AND ANTILYMPHOMA PROPERTIES OF ARSENIC AZOPROTEINS : I. ANTICOAGULANT EFFECTS OF ARSENIC AZOPROTEINS IN VIVO AND IN VITRO: COMPARISON OF ARSENICALS AS ANTICOAGULANTS AND AS ANTILYMPHOMA AGENTS: MOLECULAR STRUCTURE IN RELATION TO ANTICOAGULANT AND ANTILYMPHOMA PROPERTIES
Autor: J D, Broome, J G, Kidd
Publikováno v: The Journal of Experimental Medicine
Experiments given in this paper have shown that 4-arsonophenylazoproteins possess marked anticoagulant activity both in vivo and in vitro. Mice and rabbits given moderate amounts of the arsenic azoprotein, for example, often bled to death from injuri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::050a950194b736377d81dc9b20737df1
https://pubmed.ncbi.nlm.nih.gov/19867291
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4
THE ANTICOAGULANT AND ANTILYMPHOMA PROPERTIES OF ARSENIC AZOPROTEINS : II. COMBINATION OF ARSENIC AZOPROTEINS WITH FIBRINOGEN AND POLYMERIZING FIBRIN IN VITRO: ALTERATIONS IN MITOSIS OF LYMPHOMA 6C3HED CELLS INDUCED IN VIVO WITH ARSENIC AZOPROTEINS: DISCUSSION OF MEANS WHEREBY ARSENIC AZOPROTEINS MAY ACT UPON LYMPHOMA 6C3HED CELLS IN VIVO
Autor: J D, Broome, J G, Kidd
Publikováno v: The Journal of Experimental Medicine
Experiments here given show that 4-arsonophenylazoproteins form complexes with fibrinogen which are resistant to the enzymic action of thrombin, coagulation being thus inhibited; also that arsenic azoproteins combine strongly with polymerizing fibrin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ea7e6a757baa61582ad1a94ed603424e
https://pubmed.ncbi.nlm.nih.gov/19867292
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6
Methylation of the asparagine synthetase promoter in human leukemic cell lines is associated with a specific methyl binding protein
Autor: S Roy, J Iqbal, Y Ren, J D Broome, Y Ding
Publikováno v: Oncogene. 23(22)
We have examined the methylation profiles of the asparagine synthetase (ASY) promoter in a number of human leukemic cell lines in relation to their asparagine (ASN) requirements in vitro. Cells in which the promoter is highly methylated are auxotroph
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e6990f3fa8a726bb1d3ebdb9ff4ace
https://pubmed.ncbi.nlm.nih.gov/15048083
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7
Arsenic targets tubulins to induce apoptosis in myeloid leukemia cells
Autor: Y M, Li, J D, Broome
Publikováno v: Cancer research. 59(4)
Arsenic exhibits a differential toxicity to cancer cells. At a high concentration (5 microM), As2O3 causes acute necrosis in various cell lines. At a lower concentration (0.5-5 microm), it induces myeloid cell maturation and an arrest in metaphase, l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b37cc47db7498d1c497e5635910a1224
https://pubmed.ncbi.nlm.nih.gov/10029061
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8
Correlation between mutation in P53, p53 expression, cytogenetics, histologic type, and survival in patients with B-cell non-Hodgkin's lymphoma
Autor: P R, Koduru, K, Raju, V, Vadmal, G, Menezes, S, Shah, M, Susin, J, Kolitz, J D, Broome
Publikováno v: Blood. 90(10)
In the biology of a cell, the central role of p53 in controlling functions such as G1/S transition (check point) and DNA damage repair, and as a trigger of apoptosis, is well established. Somatic mutations or other changes in P53 have been reported i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7b5ff6bcdd77f98ead64a38c8925c599
https://pubmed.ncbi.nlm.nih.gov/9354678
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9
Clinical and morphological features of cases of trisomy 13 in acute non-lymphocytic leukemia
Autor: M, Soni, J, Brody, S L, Allen, P, Schulman, J, Kolitz, K, Rai, J D, Broome, P R, Koduru
Publikováno v: Leukemia. 10(4)
Trisomy 13 has been infrequently reported as a primary non-random karyotypic change in myeloid leukemias. To elucidate its clinical significance we examined the clinical and hematological data in nine ANLL patients in whom we found this change, in a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0e7470eb66987e0ce4859c85ad3ae601
https://pubmed.ncbi.nlm.nih.gov/8618437
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10
Deletion of cyclin-dependent kinase 4 inhibitor genes P15 and P16 in non-Hodgkin's lymphoma
Autor: P R, Koduru, M, Zariwala, M, Soni, J Z, Gong, Y, Xiong, J D, Broome
Publikováno v: Blood. 86(8)
B-cell non-Hodgkin's lymphoma (NHL) is a heterogeneous lymphoid malignancy consisting of several histologic types. Alterations in proto-oncogenes caused by reciprocal chromosome translocations have been implicated in the etiology of specific histolog
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::86bd9e17a210328b7968b956683190e1
https://pubmed.ncbi.nlm.nih.gov/7579381
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