Zobrazeno 1 - 10 of 22 pro vyhledávání: '"J D, Schuetz"'
1
Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein
Autor: V, Lecureur, D, Sun, P, Hargrove, E G, Schuetz, R B, Kim, L B, Lan, J D, Schuetz
Publikováno v: Molecular pharmacology. 57(1)
Sister of P-glycoprotein (SPGP), a novel murine cDNA and member of the ATP-binding cassette superfamily highly homologous to P-glycoprotein (Pgp), was cloned. Moreover, its genomic clone was isolated and localized to chromosome 2 by fluorescence in s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::28442f58f8ed8548c7e98921d6e6df14
https://pubmed.ncbi.nlm.nih.gov/10617675
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2
Altered expression of hepatic cytochromes P-450 in mice deficient in one or more mdr1 genes
Autor: E G, Schuetz, D R, Umbenhauer, K, Yasuda, C, Brimer, L, Nguyen, M V, Relling, J D, Schuetz, A H, Schinkel
Publikováno v: Molecular pharmacology. 57(1)
We hypothesized that the drug efflux protein P-glycoprotein (Pgp), the product of the multidrug resistance gene MDR1, might influence hepatic expression of CYP3A or other cytochromes P-450 (P-450s) because Pgp can transport endogenous regulators of t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8f502392ad7e37da3895353c0ec0115f
https://pubmed.ncbi.nlm.nih.gov/10617694
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3
Reduced folate carrier expression in acute lymphoblastic leukemia: a mechanism for ploidy but not lineage differences in methotrexate accumulation
Autor: V M, Belkov, E Y, Krynetski, J D, Schuetz, Y, Yanishevski, E, Masson, S, Mathew, S, Raimondi, C H, Pui, M V, Relling, W E, Evans
Publikováno v: Blood. 93(5)
Methotrexate (MTX) is one of the most active and widely used agents for the treatment of acute lymphoblastic leukemia (ALL). To elucidate the mechanism for higher accumulation of MTX polyglutamates (MTX-PG) in hyperdiploid ALL and lower accumulation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::596c0d35cdd14b5b7afbf485283aadfb
https://pubmed.ncbi.nlm.nih.gov/10029593
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5
Promoter and intronic sequences of the human thiopurine S-methyltransferase (TPMT) gene isolated from a human PAC1 genomic library
Autor: E Y, Krynetski, M Y, Fessing, C R, Yates, D, Sun, J D, Schuetz, W E, Evans
Publikováno v: Pharmaceutical research. 14(12)
To isolate and characterize the polymorphic human thiopurine S-methyltransferase (TPMT) gene.The human TPMT gene was isolated by PCR screening of a phage artificial chromosome (PAC) library, using exon- and intron-specific primers, then mapped and se
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dcbd0d2066d25e51ecf25fbbe3548198
https://pubmed.ncbi.nlm.nih.gov/9453052
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6
Identification of a new P-glycoprotein-like ATP-binding cassette transporter gene that is overexpressed during hepatocarcinogenesis
Autor: K N, Furuya, G, Bradley, D, Sun, E G, Schuetz, J D, Schuetz
Publikováno v: Cancer research. 57(17)
The liver is remarkably insensitive to a variety of cytotoxins and expresses a number of known drug resistance genes. To isolate new P-glycoprotein (Pgp)-related genes, we screened a normal rat liver cDNA library at low stringency with a MDR1 cDNA fr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fa4df012788b03f05aba0ec93167ab2b
https://pubmed.ncbi.nlm.nih.gov/9288777
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7
Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells
Autor: E G, Schuetz, W T, Beck, J D, Schuetz
Publikováno v: Molecular pharmacology. 49(2)
Xenobiotics frequently induce proteins involved in their detoxification. Because many drugs that are metabolized by human cytochromes P450 (CYP) 3A4 and 3A5 are also transported by the drug efflux pump P-glycoprotein, we determined whether expression
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2d8ef42925ab13623c21d961d21e1985
https://pubmed.ncbi.nlm.nih.gov/8632764
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8
Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells
Autor: J D, Schuetz, E G, Schuetz, J V, Thottassery, P S, Guzelian, S, Strom, D, Sun
Publikováno v: Molecular pharmacology. 49(1)
The human liver cytochromes P450 3A (CYP3As), orthologous to the rat glucocorticoid inducible forms, are composed of at least four differentially expressed members. To begin the study of the molecular events in the glucocorticoid regulation of CYP3A5
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::12caeae421115f5217c488d997bafb18
https://pubmed.ncbi.nlm.nih.gov/8569713
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10
Allopurinol inhibits de novo purine synthesis in lymphoblasts of children with acute lymphoblastic leukemia
Autor: E, Masson, T W, Synold, M V, Relling, J D, Schuetz, J T, Sandlund, C H, Pui, W E, Evans
Publikováno v: Leukemia. 10(1)
Allopurinol is used to prevent hyperuricemia in newly diagnosed patients with acute lymphoblastic leukemia (ALL). Although allopurinol has been shown to inhibit de novo purine synthesis (DNPS) in fibroblasts in vitro, this effect has not been assesse
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6a7f689d19c11001236f02f11a5c542a
https://pubmed.ncbi.nlm.nih.gov/8558939
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