Zobrazeno 1 - 10
of 425
pro vyhledávání: '"J D, Schuetz"'
Autor:
Alsharabasy, Amir M.1 (AUTHOR), Cherukaraveedu, Durgadas1 (AUTHOR), Warneke, Jonas2,3 (AUTHOR), Warneke, Ziyan2 (AUTHOR), Galán‐Mascarós, José Ramón4,5 (AUTHOR), Glynn, Sharon A.1,6 (AUTHOR), Farràs, Pau1,7 (AUTHOR) pau.farras@universityofgalway.ie, Pandit, Abhay1 (AUTHOR) abhay.pandit@universityofgalway.ie
Publikováno v:
Small Science. Nov2024, Vol. 4 Issue 11, p1-15. 15p.
Publikováno v:
Molecular pharmacology. 57(1)
Sister of P-glycoprotein (SPGP), a novel murine cDNA and member of the ATP-binding cassette superfamily highly homologous to P-glycoprotein (Pgp), was cloned. Moreover, its genomic clone was isolated and localized to chromosome 2 by fluorescence in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::28442f58f8ed8548c7e98921d6e6df14
https://pubmed.ncbi.nlm.nih.gov/10617675
https://pubmed.ncbi.nlm.nih.gov/10617675
Autor:
E G, Schuetz, D R, Umbenhauer, K, Yasuda, C, Brimer, L, Nguyen, M V, Relling, J D, Schuetz, A H, Schinkel
Publikováno v:
Molecular pharmacology. 57(1)
We hypothesized that the drug efflux protein P-glycoprotein (Pgp), the product of the multidrug resistance gene MDR1, might influence hepatic expression of CYP3A or other cytochromes P-450 (P-450s) because Pgp can transport endogenous regulators of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f502392ad7e37da3895353c0ec0115f
https://pubmed.ncbi.nlm.nih.gov/10617694
https://pubmed.ncbi.nlm.nih.gov/10617694
Autor:
V M, Belkov, E Y, Krynetski, J D, Schuetz, Y, Yanishevski, E, Masson, S, Mathew, S, Raimondi, C H, Pui, M V, Relling, W E, Evans
Publikováno v:
Blood. 93(5)
Methotrexate (MTX) is one of the most active and widely used agents for the treatment of acute lymphoblastic leukemia (ALL). To elucidate the mechanism for higher accumulation of MTX polyglutamates (MTX-PG) in hyperdiploid ALL and lower accumulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::596c0d35cdd14b5b7afbf485283aadfb
https://pubmed.ncbi.nlm.nih.gov/10029593
https://pubmed.ncbi.nlm.nih.gov/10029593
Publikováno v:
Advances in experimental medicine and biology. 431
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::be013a14f1fc571211f9cbd2cda42b94
https://pubmed.ncbi.nlm.nih.gov/9598082
https://pubmed.ncbi.nlm.nih.gov/9598082
Publikováno v:
Pharmaceutical research. 14(12)
To isolate and characterize the polymorphic human thiopurine S-methyltransferase (TPMT) gene.The human TPMT gene was isolated by PCR screening of a phage artificial chromosome (PAC) library, using exon- and intron-specific primers, then mapped and se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dcbd0d2066d25e51ecf25fbbe3548198
https://pubmed.ncbi.nlm.nih.gov/9453052
https://pubmed.ncbi.nlm.nih.gov/9453052
Autor:
Matsumoto, Hideki1 (AUTHOR) hmatsumoto‐gif@umin.ac.jp, Sasai, Hideo1,2 (AUTHOR), Kawamoto, Norio1 (AUTHOR), Katsuyama, Masato3 (AUTHOR), Minamiyama, Makoto4 (AUTHOR), Kuru, Satoshi4 (AUTHOR), Fukao, Toshiyuki1,2 (AUTHOR), Ohnishi, Hidenori1,2,5 (AUTHOR)
Publikováno v:
Molecular Genetics & Genomic Medicine. Jun2024, Vol. 12 Issue 6, p1-8. 8p.
Publikováno v:
Cancer research. 57(17)
The liver is remarkably insensitive to a variety of cytotoxins and expresses a number of known drug resistance genes. To isolate new P-glycoprotein (Pgp)-related genes, we screened a normal rat liver cDNA library at low stringency with a MDR1 cDNA fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fa4df012788b03f05aba0ec93167ab2b
https://pubmed.ncbi.nlm.nih.gov/9288777
https://pubmed.ncbi.nlm.nih.gov/9288777
Publikováno v:
Molecular pharmacology. 49(2)
Xenobiotics frequently induce proteins involved in their detoxification. Because many drugs that are metabolized by human cytochromes P450 (CYP) 3A4 and 3A5 are also transported by the drug efflux pump P-glycoprotein, we determined whether expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d8ef42925ab13623c21d961d21e1985
https://pubmed.ncbi.nlm.nih.gov/8632764
https://pubmed.ncbi.nlm.nih.gov/8632764
Publikováno v:
Molecular pharmacology. 49(1)
The human liver cytochromes P450 3A (CYP3As), orthologous to the rat glucocorticoid inducible forms, are composed of at least four differentially expressed members. To begin the study of the molecular events in the glucocorticoid regulation of CYP3A5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::12caeae421115f5217c488d997bafb18
https://pubmed.ncbi.nlm.nih.gov/8569713
https://pubmed.ncbi.nlm.nih.gov/8569713