OP0034 IXEKIZUMAB IMPROVES SIGNS, SYMPTOMS, AND QUALITY OF LIFE IN PATIENTS WITH AXIAL SpA IRRESPECTIVE OF DISEASE DURATION: RESULTS FROM THE COAST-V, COAST-W AND COAST-X TRIALS

Autor: V. Navarro-Compán, J. D. Reveille, P. Rahman, J. Maldonado-Cocco, M. Magrey, R. Bolce, D. Sandoval, S. Y. Park, A. Kronbergs, M. Rudwaleit

Publikováno v: Annals of the Rheumatic Diseases. 81:24.1-25

BackgroundIxekizumab (IXE), a high-affinity monoclonal antibody selectively targeting interleukin-17A,1 has demonstrated superior efficacy to placebo (PBO) in the treatment of patients (pts) with radiographic axial spondyloarthritis (r-axSpA) (COAST-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7363c0e4f5dc3e73c842db057698410e
https://doi.org/10.1136/annrheumdis-2022-eular.164

Seizures in patients with systemic lupus erythematosus: data from LUMINA, a multiethnic cohort (LUMINA LIV)

Autor: Mónica Fernández, Rosa M. Andrade, Gerald McGwin, Mandar Apte, J. D. Reveille, Luis Alonso González, Luis M. Vilá, Graciela S. Alarcón

Publikováno v: Repositorio UdeA
Universidad de Antioquia
instacron:Universidad de Antioquia

Objective To examine the predictors of time-to-seizure occurrence and their impact on damage accrual and mortality in LUMINA, a multiethnic (Hispanic, African American and Caucasian) cohort of patients with systemic lupus erythematosus. Methods Seizu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::094418e554fa32e37fefbcda03bfc569
https://doi.org/10.1136/ard.2007.077594

Frequency of HLA-DQB*06 in Caucasian, African American, and Mexican American patients with a positive direct antiglobulin test

Autor: J. D. Reveille, Wells Td, L. A. Diekman, Joann M. Moulds

Publikováno v: Immunohematology. 16:74-77

A reduced frequency of HLA-DQ6 in patients with a positive direct antiglobulin test (DAT) was previously reported but race was undisclosed. Therefore, we investigated a total of 275 patients (80 Caucasian, 113 African American, and 82 Mexican America

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb8f6bf513bfe263a4c19511ae80b3fc
https://doi.org/10.21307/immunohematology-2019-581

Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci

Autor: Peter Donnelly, Tugce Karaderi, Dafna D. Gladman, Shim S-C., Karl Gafney, Crusius Jba., J Mulero, Karena Pryce, Proton Rahman, Louise Appleton, Matthew A. Brown, Johanna Hadler, Vibeke Videm, R. Valle-Oñate, Jian Yang, Consuelo Romero-Sánchez, José Luis Fernández-Sueiro, Tony J. Kenna, Øystein Førre, Inger Myrnes Hansen, Hill Gaston, Lei Jiang, David M. Evans, Huji Xu, B P Wordsworth, Jessica Harris, Kim T-H., Panagiotis Deloukas, Gilles Chiocchia, Simon Stebbings, Benedicte A. Lie, Minghong Ward, Adrian Cortes, Javier Martín, J. D. Reveille, Philip Robinson, Maxime Breban, Michael H. Weisman, Dirk Elewaut, Walter P. Maksymowych, Xiaodong Zhou, Garchon H-J., Johannes C. Nossent, Yu Liu, Xin Wu, Nigil Haroon, J. Tuomilehto, Claire Farrah, Fernando Pimentel-Santos, Paul Leo, Miguel A. Gonzalez-Gay, J.P. Pointon, Paul Bowness, Carlos López-Larrea, Kyung Bin Joo, Ruben Burgos-Vargas, I E van der Horst-Bruinsma, Manuel A. R. Ferreira, K. Laiho, Sang-Gug Lee, Robert D. Inman, Katie Cremin, Chou C-T., J. Lau, Linda A. Bradbury

Publikováno v: Nature Genetics, 45(7), 730-738. Nature Publishing Group
NATURE GENETICS
Cortes, A, Hadler, J, Pointon, J P, Robinson, P C, Karaderi, T, Leo, P, Cremin, K, Pryce, K, Harris, J, Lee, S, Joo, K B, Shim, S C, Weisman, M, Ward, M, Zhou, X D, Garchon, H J, Chiocchia, G, Nossent, J, Lie, B A, Forre, O, Tuomilehto, J, Laiho, K, Jiang, L, Liu, Y, Wu, X, Bradbury, L A, Elewaut, D, Burgos-Vargas, R, Stebbings, S, Appleton, L, Farrah, C, Lau, J, Kenna, T J, Haroon, N, Ferreira, M A, Yang, J, Mulero, J, Fernandez-Sueiro, J L, Gonzalez-Gay, M A, Lopez-Larrea, C, Deloukas, P, Donnelly, P, Bowness, P, Gafney, K, Gaston, H, Gladman, D D, Rahman, P, Maksymowych, W P, Xu, H J, Crusius, J B A, van der Horst-Bruinsma, I E, Chou, C T, Valle-Onate, R, Romero-Sanchez, C, Hansen, I M, Pimentel-Santos, F M, Inman, R D, Videm, V, Martin, J, Breban, M, Reveille, J D, Evans, D M, Kim, T H, Wordsworth, B P & Brown, M A 2013, ' Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci ', Nature Genetics, vol. 45, no. 7, pp. 730-738 . https://doi.org/10.1038/ng.2667

Ankylosing spondylitis is a common, highly heritable inflammatory arthritis affecting primarily the spine and pelvis. In addition to HLA-B*27 alleles, 12 loci have previously been identified that are associated with ankylosing spondylitis in populati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1631c84aeabb9143f3d0cc727d31fd19
https://pubmed.ncbi.nlm.nih.gov/23749187

Autoantibody responses to the 'native' 52-kDa SS-A/Ro protein in neonatal lupus syndromes, systemic lupus erythematosus, and Sjogren's syndrome

Autor: J P Buyon, S G Slade, J D Reveille, J C Hamel, E K Chan

Publikováno v: The Journal of Immunology. 152:3675-3684

Abs to the 52-kDa SS-A/Ro protein are found in high prevalence in patients with Sjogren's syndrome (SS) and mothers whose children have the neonatal lupus syndrome (NLS). This study further defines the specificity of this response. By ELISA, 97% of 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbe221d79e8963f7beecc51cff0366d0
https://doi.org/10.4049/jimmunol.152.7.3675