Zobrazeno 1 - 10
of 14
pro vyhledávání: '"J D, Licht"'
Publikováno v:
Advances in cancer research. 131
Epigenetics, the modification of chromatin without changing the DNA sequence itself, determines whether a gene is expressed, and how much of a gene is expressed. Methylation of lysine 27 on histone 3 (H3K27me), a modification usually associated with
Autor:
J. D Licht
Publikováno v:
AACR Education book. 2008:329-334
Autor:
M J, McConnell, J D, Licht
Publikováno v:
Current topics in microbiology and immunology. 313
The PLZF gene is one of five partners fused to the retinoic acid receptor alpha in acute promyelocytic leukemia. PLZF encodes a DNA-binding transcriptional repressor and the PLZF-RARalpha fusion protein like other RARalpha fusions can inhibit the gen
Publikováno v:
Oncogene. 33:3618-3618
Publikováno v:
Blood. 96(12)
The AML-1/ETO fusion protein, created by the (8;21) translocation in M2-type acute myelogenous leukemia (AML), is a dominant repressive form of AML-1. This effect is due to the ability of the ETO portion of the protein to recruit co-repressors to pro
Autor:
A, Melnick, J D, Licht
Publikováno v:
Blood. 93(10)
Publikováno v:
Blood. 90(2)
Autor:
J D, Licht, R, Shaknovich, M A, English, A, Melnick, J Y, Li, J C, Reddy, S, Dong, S J, Chen, A, Zelent, S, Waxman
Publikováno v:
Oncogene. 12(2)
Acute promyelocytic leukemia (APL) associated with chromosomal rearrangement t(11;17) is a distinct syndrome which, unlike typical t(15;17) APL, fails to respond to all-trans retinoic acid (ATRA) therapy. In t(11;17) the PLZF gene, encoding a Krüppe
Publikováno v:
Oncogene. 11(4)
Wilms' tumor belongs to a small group of pediatric neoplasms that have served as paradigms of human cancers in which recessive mutations play a primary role in tumorigenesis. WT1 is a candidate tumor suppressor gene that is mutationally inactivated i
Autor:
A A, Scott, D R, Head, K J, Kopecky, F R, Appelbaum, K S, Theil, M R, Grever, I M, Chen, M H, Whittaker, B B, Griffith, J D, Licht
Publikováno v:
Blood. 84(1)
We have identified and characterized a previously unrecognized form of acute leukemia that shares features of both myeloid and natural killer (NK) cells. From a consecutive series of 350 cases of adult de novo acute myeloid leukemia (AML), we identif