Zobrazeno 1 - 10
of 41
pro vyhledávání: '"J D, Laskin"'
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ba0b90a818a858d47cc97a9b7eb5f8c
https://doi.org/10.1002/chin.199247194
https://doi.org/10.1002/chin.199247194
Publikováno v:
Advances in experimental medicine and biology. 500
One of the hallmarks of the inflammatory response associated with tissue injury is the accumulation of macrophages at sites of damage. These cell types release proinflammatory cytokines and cytotoxic mediators to destroy invading pathogens and initia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b49b0037d4089ea9d2bdffb40b47b8ef
https://pubmed.ncbi.nlm.nih.gov/11764933
https://pubmed.ncbi.nlm.nih.gov/11764933
Publikováno v:
Advances in experimental medicine and biology. 500
Much ongoing research in toxicology focuses on a hypothesis-driven mechanism of action approach aimed at understanding the molecular events mediating the actions of the chemicals of interest. Using this approach, investigators develop hypotheses base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c954e1062b41efed8bc4407a792effbc
https://pubmed.ncbi.nlm.nih.gov/11765017
https://pubmed.ncbi.nlm.nih.gov/11765017
Publikováno v:
Journal of leukocyte biology. 70(2)
Although initially considered merely "scavenger cells" that participate in immunologic responses only after B and T lymphocytes have performed their biological tasks, more recent evidence suggests that macrophages play a key role in host defense as w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5ff430b10283e29ed03d4db20219338
https://pubmed.ncbi.nlm.nih.gov/11493607
https://pubmed.ncbi.nlm.nih.gov/11493607
Autor:
B, Billack, D E, Heck, D M, Porterfield, R P, Malchow, P J, Smith, C R, Gardner, D L, Laskin, J D, Laskin
Publikováno v:
Biochemical pharmacology. 61(12)
Pharmacological modulation of nitric oxide synthase activity has been achieved using structural analogs of arginine. In the present studies, we demonstrated that the minimal amidine structure required for enzymatic inhibition is formamidine. We found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c678f7acc5755c91f80696efcb6746a7
https://pubmed.ncbi.nlm.nih.gov/11377388
https://pubmed.ncbi.nlm.nih.gov/11377388
Publikováno v:
Pharmacologytherapeutics. 84(3)
Nitric oxide is produced by many cell types in the lung and plays an important physiologic role in the regulation of pulmonary vasomotor tone by several known mechanisms. Nitric oxide stimulates soluble guanylyl cyclase, resulting in increased levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f6c7a5d5d6b9a35a16e404ba48575160
https://pubmed.ncbi.nlm.nih.gov/10665837
https://pubmed.ncbi.nlm.nih.gov/10665837
Publikováno v:
Biochemical pharmacology. 54(1)
Nitric oxide is an important cellular mediator produced in keratinocytes and macrophages from arginine by the enzyme nitric oxide synthase during inflammatory reactions in the skin. We found that gamma-interferon stimulated nitric oxide production an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::997c82885cd81143146c67a3c6fce587
https://pubmed.ncbi.nlm.nih.gov/9296356
https://pubmed.ncbi.nlm.nih.gov/9296356
Publikováno v:
Cancer research. 56(9)
Nitric oxide is an important cellular mediator that plays a role in regulating cellular proliferation of both normal and tumor cells. In the present study, we characterized nitric oxide production by the human colon adenocarcinoma cell line DLD-1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::847daff1710f0a1919c8e248e5d685e3
https://pubmed.ncbi.nlm.nih.gov/8616835
https://pubmed.ncbi.nlm.nih.gov/8616835
Publikováno v:
Advances in experimental medicine and biology. 387
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1ffa0480be6bbcfac4dbe3e0a7710551
https://pubmed.ncbi.nlm.nih.gov/8794206
https://pubmed.ncbi.nlm.nih.gov/8794206
Autor:
D L, Laskin, M, Rodriguez del Valle, D E, Heck, S M, Hwang, S T, Ohnishi, S K, Durham, N L, Goller, J D, Laskin
Publikováno v:
Hepatology (Baltimore, Md.). 22(1)
In the present studies, we analyzed the effects of acute endotoxemia on hepatocyte nitric oxide production and functional activity. Treatment of rats with 5 mg/kg of lipopolysaccharide (LPS), which induces acute endotoxemia, caused an increase in nit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2698fe1f5d832d5f7af582772d01843d
https://pubmed.ncbi.nlm.nih.gov/7541386
https://pubmed.ncbi.nlm.nih.gov/7541386