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In vitro and in vivo antileukemic activity of B43-pokeweed antiviral protein against radiation-resistant human B-cell precursor leukemia cells

Autor: Dorothea E. Myers, Mridula Chandan-Langlie, Kevin G. Waddick, Lisa M. Chelstrom, Nilgun Tumer, Fatih M. Uckun, J. D. Irvin, Roland Gunther

Publikováno v: Blood. 86:4228-4233

B-cell precursor (BCP) leukemia is the most common form of childhood cancer and represents one of the most radiation-resistant forms of human malignancy. In this study, we examined the antileukemic efficacy of the B43 (anti-CD19)-pokeweed antiviral p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1299e72dad8365d2638150a8e17e8520
https://doi.org/10.1182/blood.v86.11.4228.bloodjournal86114228

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Anti-human immunodeficiency virus type 1 activity of an anti-CD4 immunoconjugate containing pokeweed antiviral protein

Autor: Alejo Erice, Dorothea E. Myers, V. L. Leske, Kim J. Sannerud, Virginia M. Kuebelbeck, F. M. Uckun, Henry H. Balfour, J. D. Irvin

Publikováno v: Antimicrobial Agents and Chemotherapy. 37:835-838

The ability of an alpha CD4-pokeweed antiviral protein (PAP) immunoconjugate to inhibit replication of human immunodeficiency virus type 1 (HIV-1) was evaluated in vitro with 22 clinical HIV-1 strains obtained from four seropositive asymptomatic indi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f271deef836f36b8328163e51ea3f5b4
https://doi.org/10.1128/aac.37.4.835

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Effective immunochemotherapy of CALLA+C mu+ human pre-B acute lymphoblastic leukemia in mice with severe combined immunodeficiency using B43 (anti-CD19) pokeweed antiviral protein immunotoxin plus cyclophosphamide

Autor: Lisa Tuel-Ahlgren, Carlos Manivel, F. M. Uckun, Lisa M. Chelstrom, Dorothea E. Myers, Roland Gunther, Dale Finnegan, J. D. Irvin

Publikováno v: Blood. 79:3116-3129

A highly aggressive human CALLA+C mu+ pre-B acute lymphoblastic leukemia (ALL) cell line (NALM-6-UM1) causes disseminated and invariably fatal leukemia in CB.17 mice with severe combined immunodeficiency (SCID). We used this SCID mouse model of human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5d8fb64559c9da1b7881a87cfbbf6c0
https://doi.org/10.1182/blood.v79.12.3116.3116

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In vivo efficacy of B43 (anti-CD19)-pokeweed antiviral protein immunotoxin against BCL-1 murine B-cell leukemia

Autor: Virginia M. Kuebelbeck, Lisa M. Chelstrom, LL Houston, Dorothea E. Myers, Roland Gunther, F. M. Uckun, J. D. Irvin, Jo Anne H. Young, Dale Finnegan

Publikováno v: Blood. 79:2649-2661

We show that a highly aggressive subclone of murine BCL-1 B-lineage leukemia expresses a single 2.4-kb transcript hybridizing to the human CD19 cDNA probe and reacts strongly with the anti-human CD19 monoclonal antibodies (MoAb) B43, B4, Leu-12, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3525fb4ff18a88b9e9217513aa9f8810
https://doi.org/10.1182/blood.v79.10.2649.2649

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In vivo efficacy of B43 (anti-CD19)-pokeweed antiviral protein immunotoxin against human pre-B cell acute lymphoblastic leukemia in mice with severe combined immunodeficiency

Autor: Roland Gunther, Carlos Manivel, Dale Finnegan, Fatih M. Uckun, Lisa M. Chelstrom, Diane C. Arthur, Lisa Tuel-Ahlgren, J. D. Irvin, Dorothea E. Myers

Publikováno v: Blood. 79:2201-2214

A highly aggressive subclone of the human CALLA+C mu+ pre-B acute lymphoblastic leukemia (ALL) cell line NALM-6 (designated NALM-6-UM1) caused disseminated and fatal leukemia in CB.17 mice with severe combined immunodeficiency (SCID). An intravenous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9cd0c320a1964af1f61b002c414804e4
https://doi.org/10.1182/blood.v79.9.2201.2201

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In vivo toxicity, pharmacokinetics, and antileukemic activity of TXU (anti-CD7)-pokeweed antiviral protein immunotoxin

Autor: B, Waurzyniak, E A, Schneider, N, Tumer, Y, Yanishevski, R, Gunther, L M, Chelstrom, H, Wendorf, D E, Myers, J D, Irvin, Y, Messinger, O, Ek, T, Zeren, M C, Langlie, W E, Evans, F M, Uckun

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 3(6)

We evaluated the TXU (anti-CD7)-pokeweed antiviral protein (PAP) immunotoxin in both murine and nonhuman primate models. TXU-PAP caused dose-limiting cardiac toxicity in BALB/c mice. In a SCID mouse model of invariably fatal human T-lineage acute lym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2eef8cf4a3af580fb043ac6e2518be51
https://pubmed.ncbi.nlm.nih.gov/9815763

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Pharmacokinetic features, immunogenicity, and toxicity of B43(anti-CD19)-pokeweed antiviral protein immunotoxin in cynomolgus monkeys

Autor: F M, Uckun, Y, Yanishevski, N, Tumer, B, Waurzyniak, Y, Messinger, L M, Chelstrom, E A, Lisowski, O, Ek, T, Zeren, H, Wendorf, M C, Langlie, J D, Irvin, D E, Myers, G B, Fuller, W, Evans, R, Gunther

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 3(3)

We studied the pharmacokinetic features, immunogenicity, and toxicity of B43-pokeweed antiviral protein (PAP) immunotoxin in 13 cynomolgus monkeys. The disposition of B43-PAP in two monkeys, when administered as a single i.v. bolus dose, was characte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::901687f39f9f57c042b554c797d0e3a7
https://pubmed.ncbi.nlm.nih.gov/9815689

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Extended-release felodipine in patients with mild to moderate hypertension. Felodipine ER Dose-Response Study Group

Autor: M A, Weber, A I, Goldberg, E P, Faison, K, Lipschutz, D A, Shapiro, E B, Nelson, J D, Irvin

Publikováno v: Clinical pharmacology and therapeutics. 55(3)

Two hundred eighty-six patients with mild to moderate hypertension who had untreated diastolic blood pressure while seated of 95 to 115 mm Hg were randomized to receive placebo or once-daily doses of 2.5, 5, or 10 mg of the dihydropyridine calcium ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b89ce26a1a6c008f1f854cecd6cf8af4
https://pubmed.ncbi.nlm.nih.gov/8143399

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