Zobrazeno 1 - 10
of 46
pro vyhledávání: '"J D, Geratz"'
Publikováno v:
The Journal of Infectious Diseases
In a model for virus-induced myocarditis and congestive heart failure, rabbit coronavirus infection was divided into acute (days 2–5) and subacute (days 6–12) phases on the basis of day of death and pathologic findings. During the acute phase, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f503ed776a6c151a60ad5e61b1cfd4
https://doi.org/10.1093/infdis/165.1.134
https://doi.org/10.1093/infdis/165.1.134
Publikováno v:
The American journal of pathology. 136(4)
This report builds on the authors' earlier discovery of bis(5-amidino-2-benzimidazolyl)methane (BABIM) as a strong suppressive agent for streptococcal cell wall fragment-induced arthritis in the Lewis rat. As a synthetic inhibitor of trypsinlike prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::27e9e2d2b7ff82c7762fc6bafae8ea2d
https://pubmed.ncbi.nlm.nih.gov/2327474
https://pubmed.ncbi.nlm.nih.gov/2327474
Publikováno v:
Journal of medicinal chemistry. 33(4)
A series of 33 analogues of the anti-Pneumocystis carinii drug 1,5-bis(4-amidinophenoxy)pentane (pentamidine) was synthesized for screening against a rat model of P. carinii pneumonia (PCP). Twenty-five of the compounds showed efficacy against PCP wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1517650980aa2100c0c1fb1dfdb8135a
https://pubmed.ncbi.nlm.nih.gov/2319567
https://pubmed.ncbi.nlm.nih.gov/2319567
Publikováno v:
Antimicrobial Agents and Chemotherapy. 25:582-585
To evaluate the importance of proteolytic activity in the pathogenesis of cell injury by Rickettsia rickettsii, a series of four aromatic amidine inhibitors of trypsin-like proteases were introduced into the plaque model. The compounds were shown to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba48adfcd41e4b0cf0c0acac1468546
https://doi.org/10.1128/aac.25.5.582
https://doi.org/10.1128/aac.25.5.582
Autor:
Michael C.-F Cheng, J. D Geratz
Publikováno v:
Thrombosis and Haemostasis. 33:230-243
Summary1. Structure-activity relationships have been established for the inhibition of urokinase by aromatic diamidines. In an assay system employing purified urokinase and human plasminogen the most potent inhibitor was found in 4′,4″-diamidino-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e43772592e9b39663dd32a7878d06e65
https://doi.org/10.1055/s-0038-1647877
https://doi.org/10.1055/s-0038-1647877
Publikováno v:
Journal of Medicinal Chemistry. 26:294-298
Two series of amidine derivatives consisting of a total of 24 compounds were examined for a correlation between their blocking effect on respiratory syncytial virus induced cell fusion and their inhibitory activity against selected trypsin-like prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004f1cf9640b47a6ce98b7ec5c0fe87a
https://doi.org/10.1021/jm00356a036
https://doi.org/10.1021/jm00356a036
Autor:
J D Geratz, J C Lamb
Publikováno v:
American Journal of Physiology-Legacy Content. 227:119-122
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6669e5e81995a068beec19eba9ab0b95
https://doi.org/10.1152/ajplegacy.1974.227.1.119
https://doi.org/10.1152/ajplegacy.1974.227.1.119
Publikováno v:
Thrombosis and Haemostasis. 39:411-425
SummaryA series of aromatic amidino compounds were investigated for their inhibitory effect on platelet agglutination and platelet aggregation. Agglutination of fresh or fixed platelets was produced by bovine plasma or by human plasma in combination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23fd7e8163936d85cbc4f2cc00d6e639
https://doi.org/10.1055/s-0038-1646701
https://doi.org/10.1055/s-0038-1646701
Autor:
J. D. Geratz, Graham Jb
Publikováno v:
Thrombosis and Haemostasis. :376-388
Summary1. PTC activity was assayed in 26 units of human plasma prepared from whole blood stored for 3 weeks at 4° C. The plasma had been frozen and stored at — 20° C for additional periods ranging from a few days to 4 months. High PTC activity wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efc1528efb8ac8b7bb414d0dbf24f728
https://doi.org/10.1055/s-0038-1654521
https://doi.org/10.1055/s-0038-1654521