Výsledky vyhledávání - "J D, Ashwell"

Autor: J. D. Ashwell, Y. Yang

Publikováno v: APOPTOSIS. 6:139-146

CD4+ T cells die in individuals infected with HIV, either as a result of direct HIV infection or as uninfected “innocent bystanders”. Possible mechanisms for bystander killing include generation of viral products such as Tat or gp120 and expressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::713f34db3a0be8591c632941456e7762
https://doi.org/10.1023/a:1009600901706

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An inducible lymphocyte nuclear Ca2+/Mg(2+)-dependent endonuclease associated with apoptosis

Autor: N N Khodarev, J D Ashwell

Publikováno v: The Journal of Immunology. 156:922-931

Apoptotic cell death is typically accompanied by internucleosomal chromatin fragmentation. Although a number of candidate enzymes have been proposed, there is as yet no direct evidence for the involvement of any particular endonuclease in this proces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6570e71eb3413de024b9204e7fb6e205
https://doi.org/10.4049/jimmunol.156.3.922

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Use of bispecific heteroconjugated antibodies (anti-T cell antigen receptor x anti-MHC class II) to study activation of T cells with a full length or truncated antigen receptor zeta-chain

Autor: S Wu, Y Yang, S Sadegh-Nasseri, J D Ashwell

Publikováno v: The Journal of Immunology. 150:2211-2221

Ligand-induced activation of T cells involves recognition of monovalent peptide Ag complexed with a cell surface MHC-encoded molecule. In contrast, antibody-induced activation of T cells typically requires external cross-linking of the TCR. To examin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a95550772cf28ad52a158b919ac88f16
https://doi.org/10.4049/jimmunol.150.6.2211

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Role of Ly-6A/E and T cell receptor-zeta for IL-2 production. Phosphatidylinositol-anchored Ly-6A/E antagonizes T cell receptor-mediated IL-2 production by a zeta-independent pathway

Autor: E K Codias, T J Fleming, C M Zacharchuk, J D Ashwell, T R Malek

Publikováno v: The Journal of Immunology. 149:1825-1852

Ly-6A/E molecules were originally implicated in regulation of T cell activation because anti-Ly-6A/E mAb induce IL-2 production. More recently we have shown that anti-Ly-6A/E also inhibits IL-2 production induced by anti-CD3. In the present study we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61625712861807fab7dcc0dfecd686c8
https://doi.org/10.4049/jimmunol.149.6.1825

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Variations in thymocyte susceptibility to clonal deletion during ontogeny. Implications for neonatal tolerance

Autor: C M Zacharchuk, M Merćep, C H June, A M Weissman, J D Ashwell

Publikováno v: The Journal of Immunology. 147:460-465

Activation of immature thymocytes via the TCR results in programmed cell death and clonal deletion. We have examined thymocytes from mice of different ages and observed that, whereas TCR-mediated signaling caused deletion of thymocytes from newborn a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::881d6c2cb05747861561d5de837b0d04
https://doi.org/10.4049/jimmunol.147.2.460

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Programmed T lymphocyte death. Cell activation- and steroid-induced pathways are mutually antagonistic

Autor: C M Zacharchuk, M Merćep, P K Chakraborti, S S Simons, J D Ashwell

Publikováno v: The Journal of Immunology. 145:4037-4045

Both cellular activation signals and exposure to glucocorticoids such as dexamethasone (Dex) cause programmed cell death in T cell hybridomas. When cells were activated in the presence of Dex, however, the degree of killing that was achieved by eithe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ced762b1864264797db7d6a7b20765d9
https://doi.org/10.4049/jimmunol.145.12.4037

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Model cell lines for the study of apoptosis in vitro

Autor: C, Valavanis, Y, Hu, Y, Yang, B A, Osborne, S, Chouaib, L, Greene, J D, Ashwell, L M, Schwartz

Publikováno v: Methods in cell biology. 66

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::28fe815e2ff39d046a7046d05199ac71
https://pubmed.ncbi.nlm.nih.gov/11396014

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Thymocyte apoptosis

Autor: Y, Yang, J D, Ashwell

Publikováno v: Journal of clinical immunology. 19(6)

Apoptosis is the fate of most thymocytes. Many molecules participate in the decision of whether a thymocyte is to live or to die, including cell surface receptors, such as the T cell receptor for antigen, Notch-1, and costimulatory receptors, ligand-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cd098df418e045824aa4125c39f9b99c
https://pubmed.ncbi.nlm.nih.gov/10634208

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Thymus-derived glucocorticoids set the thresholds for thymocyte selection by inhibiting TCR-mediated thymocyte activation

Autor: M S, Vacchio, J Y, Lee, J D, Ashwell

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(3)

Selection processes in the thymus eliminate nonfunctional or harmful T cells and allow the survival of those cells with the potential to recognize Ag in association with self-MHC-encoded molecules (Ag/MHC). We have previously demonstrated that thymus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ac141d8fc5ac194b620724fbf6fa14cf
https://pubmed.ncbi.nlm.nih.gov/10415031

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