Výsledky vyhledávání

Prolonged Insulin Independence After Islet Allotransplants in Recipients with Type 1 Diabetes

Autor: M D, Bellin, R, Kandaswamy, J, Parkey, H-J, Zhang, B, Liu, S H, Ihm, J D, Ansite, J, Witson, P, Bansal-Pakala, A N, Balamurugan, K K, Papas, K, Papas, D E R, Sutherland, A, Moran, B J, Hering

Publikováno v: American Journal of Transplantation. 8:2463-2470

We sought to determine the long-term outcomes in type 1 diabetic recipients of intraportal alloislet transplants on a modified immunosuppressive protocol. Six recipients with hypoglycemia unawareness received one to two islet infusions. Induction the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc210edd28330955d09c74ae29a23290
https://doi.org/10.1111/j.1600-6143.2008.02404.x

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Insulin down-regulates the inducible nitric oxide synthase pathway: nitric oxide as cause and effect of diabetes?

Autor: R B Stevens, D E Sutherland, J D Ansite, M Saxena, T J Rossini, B K Levay-Young, B J Hering, C D Mills

Publikováno v: The Journal of Immunology. 159:5329-5335

Evidence in this paper indicates that insulin can down-regulate the inducible nitric oxide synthase (iNOS) pathway in vivo. The iNOS pathway is up-regulated in diabetes-prone rats and mice and is associated with an autoimmune process. However, the re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f52d69bce4a9c21bf51903deeb8deb0
https://doi.org/10.4049/jimmunol.159.11.5329

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Modulation of immune responses after portal venous injection of antigen

Autor: L E, Wrenshall, J D, Ansite, P M, Eckman, M J, Heilman, R B, Stevens, D E, Sutherland

Publikováno v: Transplantation. 71(7)

How the localization of antigen to the liver, through means such as oral ingestion, induces tolerance is poorly understood.To elucidate potential mechanisms we used an adoptive transfer system wherein ova-specific T cells were infused into a syngenei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a9fc473c9801a2f490b34f437f266e83
https://pubmed.ncbi.nlm.nih.gov/11349714

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Insulin down-regulates the inducible nitric oxide synthase pathway: nitric oxide as cause and effect of diabetes?

Autor: R B, Stevens, D E, Sutherland, J D, Ansite, M, Saxena, T J, Rossini, B K, Levay-Young, B J, Hering, C D, Mills

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 159(11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::15f7333f11805451cb1c5b1bd2162c16
https://pubmed.ncbi.nlm.nih.gov/9548472

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Nitric oxide mediates early dysfunction of rat and mouse islets after transplantation

Autor: R B, Stevens, J D, Ansite, C D, Mills, A, Lokeh, T J, Rossini, M, Saxena, R R, Brown, D E, Sutherland

Publikováno v: Transplantation. 61(12)

Evidence presented in this paper indicates that nitric oxide (NO), generated by a nonspecific "wound"-type of inflammation, is an important mediator of the early dysfunction of transplanted islets in rodents. Although allogeneic islets stimulate NO p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b3a88607c21493b3c706c38a7c84a547
https://pubmed.ncbi.nlm.nih.gov/8685954

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Expression of intrahepatic inducible nitric oxide synthetase mRNA correlates with production of nitric oxide during intraportal isogeneic and allogeneic rat islet transplantation

Autor: R B, Stevens, J D, Ansite, A, Lokeh, T J, Rossini, C D, Mills, D E, Sutherland

Publikováno v: Transplantation proceedings. 27(1)

Intrahepatic NO production is related to the islet mass transplanted. Nitric oxide production is higher in recipients of allogeneic rather than syngeneic islets. In addition, in allogeneic recipients a possible second peak of NO production was observ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::842c3b940964ff957d8f1eeb069010b7
https://pubmed.ncbi.nlm.nih.gov/7533428

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