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Molecular analysis of the same HIV peptide functionally binding to both a class I and a class II MHC molecule

Autor: T Takeshita, H Takahashi, S Kozlowski, J D Ahlers, C D Pendleton, R L Moore, Y Nakagawa, K Yokomuro, B S Fox, D H Margulies

Publikováno v: The Journal of Immunology. 154:1973-1986

Although several peptides have been found to bind to both class I and class II molecules, the basis for this binding of the same peptide to two classes of MHC molecules has not been compared previously. We have analyzed one such peptide, P18 from the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e5926c9669d9a7048668fb67b927d0b
https://doi.org/10.4049/jimmunol.154.4.1973

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Construction of an HIV-1 peptide vaccine containing a multideterminant helper peptide linked to a V3 loop peptide 18 inducing strong neutralizing antibody responses in mice of multiple MHC haplotypes after two immunizations

Autor: J D Ahlers, C D Pendleton, N Dunlop, A Minassian, P L Nara, J A Berzofsky

Publikováno v: The Journal of Immunology. 150:5647-5665

Peptide constructs comprised of multideterminant Th peptides from the envelope glycoprotein of HIV previously identified to induce proliferative responses in four different haplotypes of mice and IL-2 responses in 52 to 73% of HIV positive, Ag-respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c786df2c61905d82235fde9a6e832920
https://doi.org/10.4049/jimmunol.150.12.5647

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Activating CTL precursors to reveal CTL function without skewing the repertoire by in vitro expansion

Autor: I M, Belyakov, J, Wang, R, Koka, J D, Ahlers, J T, Snyder, R, Tse, J, Cox, J S, Gibbs, D H, Margulies, J A, Berzofsky

Publikováno v: European journal of immunology. 31(12)

Detection of the functional CD8(+) CTL response usually requires in vitro restimulation. The differences between the CD8(+) CTL repertoire in freshly isolated precursor cells and CD8(+) CTL after short-term in vitro expansion have been generally assu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5a670952eb2d3a53a9b8c6949dbc3860
https://pubmed.ncbi.nlm.nih.gov/11745375

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A model for CD8+ CTL tumor immunosurveillance and regulation of tumor escape by CD4 T cells through an effect on quality of CTL

Autor: S, Matsui, J D, Ahlers, A O, Vortmeyer, M, Terabe, T, Tsukui, D P, Carbone, L A, Liotta, J A, Berzofsky

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(1)

Understanding immune mechanisms influencing cancer regression, recurrence, and metastasis may be critical to developing effective immunotherapy. Using a tumor expressing HIV gp160 as a model viral tumor Ag, we found a growth-regression-recurrence pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b794306c57e29b547f7705161c1c7154
https://pubmed.ncbi.nlm.nih.gov/10384115

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Cytokine-in-adjuvant steering of the immune response phenotype to HIV-1 vaccine constructs: granulocyte-macrophage colony-stimulating factor and TNF-alpha synergize with IL-12 to enhance induction of cytotoxic T lymphocytes

Autor: J D, Ahlers, N, Dunlop, D W, Alling, P L, Nara, J A, Berzofsky

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 158(8)

To enhance and steer immune responses to synthetic peptide vaccines toward selected functional types and to understand the cooperative action of cytokines in fine-tuning the immune response, we attempted to influence the in vivo cytokine environment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::84c65eb9ccc35924505a6b5006f06287
https://pubmed.ncbi.nlm.nih.gov/9103465

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Tank farm backlog soil sample analysis plan

Autor: J. D. Ahlers

This document describes the measures to collect samples, perform testing on samples, and make decisions to obtain a Contained- in Determination for tank farms backlog soil.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::380417686bc39eb9c10401c7d1e25f42
https://doi.org/10.2172/657834

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Synthetic peptides from P. falciparum sexual stage 25-kDa protein induce antibodies that react with the native protein: the role of IL-2 and conformational structure on immunogenicity of Pfs25

Autor: I A, Quakyi, L H, Miller, M F, Good, J D, Ahlers, S N, Isaacs, J H, Nunberg, R A, Houghten, D B, Keister, J E, Coligan, B, Moss

Publikováno v: Peptide research. 8(6)

To identify B-cell epitopes of the Plasmodium falciparum 25-kDa ookinete protein, Pfs25, 41 overlapping synthetic peptides spanning the entire length of the protein were used individually to immunize CAF1 (F1 hybrid of BALB/c female and A/J male) mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::737f3ad847cca5bb410efabaa6b77d65
https://pubmed.ncbi.nlm.nih.gov/8838417

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Molecular analysis of the same HIV peptide functionally binding to both a class I and a class II MHC molecule

Autor: T, Takeshita, H, Takahashi, S, Kozlowski, J D, Ahlers, C D, Pendleton, R L, Moore, Y, Nakagawa, K, Yokomuro, B S, Fox, D H, Margulies

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 154(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a5beb6179458fab9980abe444046dd1f
https://pubmed.ncbi.nlm.nih.gov/7530749

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