Zobrazeno 1 - 10
of 2 185
pro vyhledávání: '"J Cutler"'
Autor:
Shanta Murthy, Murugadas Anbazhagan, Sushma Chowdary Maddipatla, Vasantha L. Kolachala, Anne Dodd, Ranjit Pelia, David J. Cutler, Jason D. Matthews, Subra Kugathasan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Perianal fistulizing Crohn’s disease (CD) is a severe gastrointestinal disorder causing extensive mucosal damage with limited treatment options. Severe manifestations of the disease appear at higher rates in non-Europeans but the genetic a
Externí odkaz:
https://doaj.org/article/9e986aae16f04da0b37b685264521a99
PTGER4 signaling regulates class IIa HDAC function and SPINK4 mRNA levels in rectal epithelial cells
Autor:
Murugadas Anbazhagan, Garima Sharma, Shanta Murthy, Sushma Chowdary Maddipatla, Vasantha L. Kolachala, Anne Dodd, Amanda Randunne, David J. Cutler, Subra Kugathasan, Jason D. Matthews
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-14 (2024)
Abstract Background The prostaglandin receptor PTGER4 facilitates homeostasis in the gut. Previous reports indicate that goblet cells, marked by SPINK4 expression, might be affected by PTGER4 activity. Current evidence suggests that prostaglandin E2
Externí odkaz:
https://doaj.org/article/703b6ce950e24a41929fb944510436e4
Publikováno v:
Canadian Journal of Infectious Diseases and Medical Microbiology, Vol 26, Iss 5, Pp 268-272 (2015)
BACKGROUND: The incidence of syphilis in Ottawa, Ontario, has risen substantially since 2000 to six cases per 100,000 in 2003, again to nine cases per 100,000 in 2007, and recently rose to 11 cases per 100,000 in 2010. The number of cases reported in
Externí odkaz:
https://doaj.org/article/c6ac503834094dd4ad1f4e4f7ecf69ef
Autor:
R. Bergua, W. Wiley, A. Robertson, J. Jonkman, C. Brun, J.-P. Pineau, Q. Qian, W. Maoshi, A. Beardsell, J. Cutler, F. Pierella, C. A. Hansen, W. Shi, J. Fu, L. Hu, P. Vlachogiannis, C. Peyrard, C. S. Wright, D. Friel, Ø. W. Hanssen-Bauer, C. R. dos Santos, E. Frickel, H. Islam, A. Koop, Z. Hu, J. Yang, T. Quideau, V. Harnois, K. Shaler, S. Netzband, D. Alarcón, P. Trubat, A. Connolly, S. B. Leen, O. Conway
Publikováno v:
Wind Energy Science, Vol 9, Pp 1025-1051 (2024)
This paper provides a summary of the work done within Phase IV of the Offshore Code Comparison Collaboration, Continued with Correlation and unCertainty (OC6) project, under International Energy Agency Wind Technology Collaboration Programme Task 30.
Externí odkaz:
https://doaj.org/article/45372a77a91440cab355bbcc4a9b99d9
Autor:
Andrew J. Bass, Shijia Bian, Aliza P. Wingo, Thomas S. Wingo, David J. Cutler, Michael P. Epstein
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract The "missing" heritability of complex traits may be partly explained by genetic variants interacting with other genes or environments that are difficult to specify, observe, and detect. We propose a new kernel-based method called Latent Inte
Externí odkaz:
https://doaj.org/article/31a9df1724b94cce8752847fba481226
Autor:
Andrew J. Cutler, Scott H. Kollins, Matthew N. Brams, Meg Corliss, Charles Oh, Rene Braeckman, Ann C. Childress
Publikováno v:
Frontiers in Psychiatry, Vol 15 (2024)
ObjectiveTo evaluate treatment responder rate using the Attention-Deficit/Hyperactivity Disorder Rating Scale-5 (ADHD-RS-5) score based on optimized dose level of serdexmethylphenidate/dexmethylphenidate (SDX/d-MPH) and changes in ADHD severity in ch
Externí odkaz:
https://doaj.org/article/9df65ce3c2874ac88d12e6b98ba5c9f5
Autor:
Courtney Astore, Shivam Sharma, Sini Nagpal, NIDDK IBD Genetics Consortium, David J. Cutler, John D. Rioux, Judy H. Cho, Dermot P. B. McGovern, Steven R. Brant, Subra Kugathasan, I. King Jordan, Greg Gibson
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background Identification of rare variants involved in complex, polygenic diseases like Crohn’s disease (CD) has accelerated with the introduction of whole exome/genome sequencing association studies. Rare variants can be used in both diag
Externí odkaz:
https://doaj.org/article/8f9e0188c6be480bafe56d775e5c30cf
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract The pathophysiology of major depressive disorder (MDD) is thought to result from impaired connectivity between key brain networks. Gamma-aminobutyric acid (GABA) is the key inhibitory neurotransmitter in the brain, working primarily via GABA
Externí odkaz:
https://doaj.org/article/68754b99e0274125a9655f0b3a197458
Autor:
Adeela Afzal, Gabriella Agazie, Akash Anumarlapudi, Anne M. Archibald, Zaven Arzoumanian, Paul T. Baker, Bence Bécsy, Jose Juan Blanco-Pillado, Laura Blecha, Kimberly K. Boddy, Adam Brazier, Paul R. Brook, Sarah Burke-Spolaor, Rand Burnette, Robin Case, Maria Charisi, Shami Chatterjee, Katerina Chatziioannou, Belinda D. Cheeseboro, Siyuan Chen, Tyler Cohen, James M. Cordes, Neil J. Cornish, Fronefield Crawford, H. Thankful Cromartie, Kathryn Crowter, Curt J. Cutler, Megan E. DeCesar, Dallas DeGan, Paul B. Demorest, Heling Deng, Timothy Dolch, Brendan Drachler, Richard von Eckardstein, Elizabeth C. Ferrara, William Fiore, Emmanuel Fonseca, Gabriel E. Freedman, Nate Garver-Daniels, Peter A. Gentile, Kyle A. Gersbach, Joseph Glaser, Deborah C. Good, Lydia Guertin, Kayhan Gültekin, Jeffrey S. Hazboun, Sophie Hourihane, Kristina Islo, Ross J. Jennings, Aaron D. Johnson, Megan L. Jones, Andrew R. Kaiser, David L. Kaplan, Luke Zoltan Kelley, Matthew Kerr, Joey S. Key, Nima Laal, Michael T. Lam, William G. Lamb, T. Joseph W. Lazio, Vincent S. H. Lee, Natalia Lewandowska, Rafael R. Lino dos Santos, Tyson B. Littenberg, Tingting Liu, Duncan R. Lorimer, Jing Luo, Ryan S. Lynch, Chung-Pei Ma, Dustin R. Madison, Alexander McEwen, James W. McKee, Maura A. McLaughlin, Natasha McMann, Bradley W. Meyers, Patrick M. Meyers, Chiara M. F. Mingarelli, Andrea Mitridate, Jonathan Nay, Priyamvada Natarajan, Cherry Ng, David J. Nice, Stella Koch Ocker, Ken D. Olum, Timothy T. Pennucci, Benetge B. P. Perera, Polina Petrov, Nihan S. Pol, Henri A. Radovan, Scott M. Ransom, Paul S. Ray, Joseph D. Romano, Shashwat C. Sardesai, Ann Schmiedekamp, Carl Schmiedekamp, Kai Schmitz, Tobias Schröder, Levi Schult, Brent J. Shapiro-Albert, Xavier Siemens, Joseph Simon, Magdalena S. Siwek, Ingrid H. Stairs, Daniel R. Stinebring, Kevin Stovall, Peter Stratmann, Jerry P. Sun, Abhimanyu Susobhanan, Joseph K. Swiggum, Jacob Taylor, Stephen R. Taylor, Tanner Trickle, Jacob E. Turner, Caner Unal, Michele Vallisneri, Sonali Verma, Sarah J. Vigeland, Haley M. Wahl, Qiaohong Wang, Caitlin A. Witt, David Wright, Olivia Young, Kathryn M. Zurek, The NANOGrav Collaboration
Publikováno v:
The Astrophysical Journal Letters, Vol 971, Iss 1, p L27 (2024)
Externí odkaz:
https://doaj.org/article/2a220bbebfb14f09b1dffb91f2eaa820
Autor:
Suresh Venkateswaran, Hari K. Somineni, Jason D. Matthews, Varun Kilaru, Jeffrey S. Hyams, Lee A. Denson, Richard Kellamayer, Greg Gibson, David J. Cutler, Karen N. Conneely, Alicia K. Smith, Subra Kugathasan
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)
Abstract Background In peripheral blood, DNA methylation (DNAm) patterns in inflammatory bowel disease patients reflect inflammatory status rather than disease status. Here, we examined DNAm in diseased rectal mucosa from ulcerative colitis (UC) pati
Externí odkaz:
https://doaj.org/article/775c2f58680944ca846097a854389076