Výsledky vyhledávání

Persistently Raised Serum Titanium Levels After Spinal Instrumentation in Children

Autor: Peter J, Cundy, Georgia, Antoniou, Brian J C, Freeman, William J, Cundy

Publikováno v: Spine. 47:1241-1247

Prospective study of patients undergoing elective spinal deformity surgery with repeated testing for circulating metal ions including preoperative levels acting as controls.The aim was to determine if levels of particular circulating metal ions are m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0497e52a43941248b1e632c2097ca5c3
https://doi.org/10.1097/brs.0000000000004406

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Novel irreversible peptidic inhibitors of transglutaminase 2

Autor: Nicholas J. Cundy, Jane Arciszewski, Eric W. J. Gates, Sydney L. Acton, Kyle D. Passley, Ernest Awoonor-Williams, Elizabeth K. Boyd, Nancy Xu, Élise Pierson, Catalina Fernandez-Ansieta, Marie R. Albert, Nicole M. R. McNeil, Gautam Adhikary, Richard L. Eckert, Jeffrey W. Keillor

Publikováno v: RSC Medicinal Chemistry. 14:378-385

A novel peptidic scaffold was used to design a library of inhibitors that exhibit exceptional efficiency against tissue transglutaminase, providing a framework for the development of potent research tools.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c159353d9e858704927ca034bfabd33
https://doi.org/10.1039/d2md00417h

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Chromium Metal Ion Release During Instrumented Spinal Surgery in Children

Autor: Annika Mascarhenas, Georgia Antoniou, Brian J. C. Freeman, Peter J. Cundy, William J. Cundy

Publikováno v: Spine. 45:1619-1624

Study design Prospective 2-year study with operative sampling and in-vitro analysis of chromium ions following spinal surgery in children. Objectives To measure metal ion levels at pre-operative, intra-operative and post-operative times to determine

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https://doi.org/10.1097/brs.0000000000003661

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Interobserver and Intraobserver Reliability in the Salter Classification of Avascular Necrosis of the Femoral Head in Developmental Dysplasia of the Hip

Autor: Kishore Mulpuri, Wudbhav N. Sankar, Peter J. Cundy, Ethan Ponton, John H. Wedge, Charles T. Price, Emily K. Schaeffer, Harry K.W. Kim, Simon P. Kelley, Nicholas Clarke

Publikováno v: Journal of Pediatric Orthopedics

Supplemental Digital Content is available in the text.
Background: Avascular necrosis (AVN) of the femoral head is a concerning complication that can result from treatments for developmental dysplasia of the hip (DDH). AVN can lead to degenerati

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https://doi.org/10.1097/bpo.0000000000001979

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Local Bone Grafting Is Sufficient for Instrumented Adolescent Idiopathic Scoliosis Surgery: A Preliminary Study

Autor: Peter J. Cundy, Abhay D. Gahukamble, Brian J. C. Freeman, Alper Yataganbaba, Georgia Antoniou

Publikováno v: Journal of Pediatric Orthopedics

Background Several options for grafting exist; iliac crest bone grafting, allografts, and bone substitutes. Local bone graft (LBG) offers high-quality bone graft and no commercial cost. The aim of this study was to assess the clinical and radiologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c73cc0a42ec5b9f42e84e1626779c39a
https://doi.org/10.1097/bpo.0000000000001865

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The coronal aorto‐mesenteric orientation theory for post‐operative nausea and vomiting following scoliosis surgery in children: a pilot study

Autor: Roger Gent, Michael L Smith, Peter J. Cundy, George D Dounas, Thomas P. Cundy, Leanne M. Sutherland, Georgia Antoniou

Publikováno v: ANZ Journal of Surgery. 91:174-178

Background Post-operative nausea and vomiting (PONV) is often encountered following corrective scoliosis surgery in children, frequently attributed to high-dose opiate administration. PONV is a frequent cause of prolonged hospital stay. Mechanisms re

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https://doi.org/10.1111/ans.16438

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Clubfoot deformity in the Solomon Islands: Melanesian versus Polynesian ethnicity, a retrospective cohort study

Autor: Georgia Antoniou, Peter J. Cundy, Stephen Sikaveke Kodovaru, Maya Rani Louise Chandra Todd

Publikováno v: Journal of Children's Orthopaedics

Purpose Congenital talipes equinovarus (CTEV) has a high incidence in the South Pacific, with New Zealand Maori and Polynesian rates of up to seven per 1000 live births, at least five times higher than the Caucasian population. A genetic component is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0609300421f95d3cce94593f4687c5
https://doi.org/10.1302/1863-2548.14.190172

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Structure-activity relationships of N-terminal variants of peptidomimetic tissue transglutaminase inhibitors

Autor: Nicole M.R. McNeil, Eric W.J. Gates, Neda Firoozi, Nicholas J. Cundy, Jessica Leccese, Sarah Eisinga, Joel D.A. Tyndall, Gautam Adhikary, Richard L. Eckert, Jeffrey W. Keillor

Publikováno v: European journal of medicinal chemistry. 232

Tissue transglutaminase (TG2) is a multifunctional protein that catalyses protein crosslinking in the extracellular matrix, and functions as an intracellular G-protein. While both activities have been associated with human diseases, its role as a G-p

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https://pubmed.ncbi.nlm.nih.gov/35158154

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Design, synthesis and evaluation of tryptophan analogues as tool compounds to study IDO1 activity

Autor: Emma Lloyd Raven, Richard S. Grainger, John Gordon, Omar S. Qureshi, Thomas A. Jowitt, Catherine A. Brady, Nicholas J. Cundy, Nicholas M. Barnes, Roseanna K. Hare, Andrew G. Leach, Sam Butterworth, Tina Tang

Publikováno v: RSC Chemical Biology
Cundy, N J, Hare, R K, Tang, T, Leach, A G, Jowitt, T A, Qureshi, O, Gordon, J, Barnes, N M, Brady, C A, Raven, E L, Grainger, R S & Butterworth, S 2021, ' Design, synthesis and evaluation of tryptophan analogues as tool compounds to study IDO1 activity ', RSC Chemical Biology . https://doi.org/10.1039/D0CB00209G

The metabolism of l-tryptophan to N-formyl-l-kynurenine by indoleamine-2,3-dioxygenase 1 (IDO1) is thought to play a critical role in tumour-mediated immune suppression. Whilst there has been significant progress in elucidating the overall enzymatic

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https://pubmed.ncbi.nlm.nih.gov/34977580

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Disruption of paediatric orthopaedic hospital services due to the COVID-19 pandemic in a region with minimal COVID-19 illness

Autor: Georgia Antoniou, Peter J. Cundy, Nicole Williams, Fui Lin Wong

Publikováno v: Journal of Children's Orthopaedics

Purpose This study was designed to evaluate the impact of the COVID-19 pandemic on paediatric orthopaedic services in a paediatric tertiary hospital in South Australia. Methods A retrospective audit was conducted of orthopaedic activity at a major pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5904581c375c41bc7d0d1bdba830a7
https://pubmed.ncbi.nlm.nih.gov/32874355

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