Zobrazeno 1 - 10
of 18
pro vyhledávání: '"J Craig Blain"'
Publikováno v:
eLife, Vol 5 (2016)
The nonenzymatic replication of RNA is a potential transitional stage between the prebiotic chemistry of nucleotide synthesis and the canonical RNA world in which RNA enzymes (ribozymes) catalyze replication of the RNA genomes of primordial cells. Ho
Externí odkaz:
https://doaj.org/article/0dea3afe82ff4d9eb55587753acbaae5
Autor:
Ashley Maillet, Fei Liu, Chao Fang, Jinxing Li, Neil Kubica, Lars Kolster Petersen, Donovan N. Chin, Nils Jakob Vest Hansen, Luis A. Barrera, Jenifer B Kaplan, Herschel Mukherjee, Gnanasambandam Kumaravel, J Craig Blain, Lee E Vandivier, Jessica E. Friedman, Allan Beck Christensen, David M. Chenoweth, Jennifer C. Petter
Publikováno v:
ACS Chemical Biology. 15:2374-2381
RNA is emerging as a valuable target for the development of novel therapeutic agents. The rational design of RNA-targeting small molecules, however, has been hampered by the relative lack of methods for the analysis of small molecule-RNA interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7520d11f7303715e89e8764fd08c5649
https://doi.org/10.1021/acschembio.0c00357
https://doi.org/10.1021/acschembio.0c00357
Publikováno v:
Methods (San Diego, Calif.). 205
In the development of therapeutics, it is important to establish engagement of a compound to its intended target and identify other targets it binds to. Methods for demonstrating target engagement in the growing field of RNA-targeted therapeutics are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2afdb180a82820efaa8373eccace26e
https://pubmed.ncbi.nlm.nih.gov/35764246
https://pubmed.ncbi.nlm.nih.gov/35764246
Autor:
J. Craig Blain, Victor S. Lelyveld, Weicheng Zhang, Chun Pong Tam, Anders Björkbom, Shenglong Zhang, Jack W. Szostak
Publikováno v:
Journal of the American Chemical Society
Mass spectrometry (MS) is a powerful technique for characterizing noncanonical nucleobases and other chemical modifications in small RNAs, yielding rich chemical information that is complementary to high-throughput indirect sequencing. However, mass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5ae401545570ba4e5fd6e79c12a856
https://doi.org/10.1021/jacs.5b09438
https://doi.org/10.1021/jacs.5b09438
Autor:
Albert C. Fahrenbach, Enver Cagri Izgu, Li Li, J. Craig Blain, Aaron T. Larsen, Wen Zhang, Jack W. Szostak, Na Zhang
Publikováno v:
Journal of the American Chemical Society
The nonenzymatic replication of primordial RNA is thought to have been a critical step in the origin of life. However, despite decades of effort, the poor rate and fidelity of model template copying reactions have thus far prevented an experimental d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054220348673693dc5e1bb51f7ce991d
https://doi.org/10.1021/jacs.5b02707
https://doi.org/10.1021/jacs.5b02707
Publikováno v:
Proceedings of the National Academy of Sciences. 110:17732-17737
Recent advances suggest that it may be possible to construct simple artificial cells from two subsystems: a self-replicating cell membrane and a self-replicating genetic polymer. Although multiple pathways for the growth and division of model protoce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f108f48cbf0bc7d6115a8b1c6344dd6
https://doi.org/10.1073/pnas.1312329110
https://doi.org/10.1073/pnas.1312329110
Publikováno v:
Journal of the American Chemical Society
A fast and accurate pathway for nonenzymatic RNA replication would simplify models for the emergence of the RNA world from the prebiotic chemistry of the early earth. However, numerous difficulties stand in the way of an experimental demonstration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b42269757d97f70aaabfe51916d25c2
https://doi.org/10.1021/ja311164j
https://doi.org/10.1021/ja311164j
Publikováno v:
eLife, Vol 5 (2016)
eLife
eLife
The nonenzymatic replication of RNA is a potential transitional stage between the prebiotic chemistry of nucleotide synthesis and the canonical RNA world in which RNA enzymes (ribozymes) catalyze replication of the RNA genomes of primordial cells. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d560a5df03077221b8a87dcbb32bf1
https://elifesciences.org/articles/17756
https://elifesciences.org/articles/17756
Publikováno v:
Chemistry - A European Journal. 18:12609-12613
Two nitroimidazole modified thymidines 1a and 1b have been synthesized and incorporated into DNA oligomers. The 350 nm photolysis of 1a and 1b generated a 5-(2′-deoxyuridinyl)methyl radical that induced DNA interstrand cross-links (ICL). Higher ICL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369a703596b4fd4f690b585546c5e085
https://doi.org/10.1002/chem.201201960
https://doi.org/10.1002/chem.201201960