Zobrazeno 1 - 10
of 65
pro vyhledávání: '"J Craig, Rowlands"'
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0127952 (2015)
A stochastic model of nuclear receptor-mediated transcription was developed based on activation of the aryl hydrocarbon receptor (AHR) by 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and subsequent binding the activated AHR to xenobiotic response elements
Externí odkaz:
https://doaj.org/article/8575df5f2d804c5389c56fe8817d65b7
Autor:
Donna L. Mendrick, Elizabeth A. Maull, J. Craig Rowlands, David Allen, Stephen W. Edwards, Warren Casey, Michelle R. Embry, Joanna Matheson, Kristie Sullivan, Nicole Kleinstreuer, Sharon Munn
Publikováno v:
Regulatory Toxicology and Pharmacology. 76:39-50
An adverse outcome pathway (AOP) helps to organize existing knowledge on chemical mode of action, starting with a molecular initiating event such as receptor binding, continuing through key events, and ending with an adverse outcome such as reproduct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17bc60886aa2e179dcb61f7ee451c170
https://doi.org/10.1016/j.yrtph.2016.01.007
https://doi.org/10.1016/j.yrtph.2016.01.007
Autor:
J. Craig Rowlands, Abraham Nyska, Robert A. Budinsky, Greg D. Martin, Marie Lawson, Russell S. Thomas, Renee R. Hukkanen, Debra K. Layko, Rosa Anna Manno, Andrea Grassetti, Joshua A. Harrill
Publikováno v:
Journal of Applied Toxicology. 36:802-814
Sustained activation of the aryl hydrocarbon receptor (AHR) is believed to be the initial key event in AHR receptor-mediated tumorigenesis in the rat liver. The role of AHR in mediating pathological changes in the liver prior to tumor formation was i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::821688cf2c0e2d47992e6dcf95d50e8f
https://doi.org/10.1002/jat.3211
https://doi.org/10.1002/jat.3211
Autor:
Lola M. Reid, Russell S. Thomas, J. Craig Rowlands, Eliane Wauthier, Bethany Parks, Joshua A. Harrill
Publikováno v:
Hepatology (Baltimore, Md.)
Rodent cancer bioassays indicate that the aryl hydrocarbon receptor (AHR) agonist, 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD), causes increases in both hepatocytic and cholangiocytic tumors. Effects of AHR activation have been evaluated on rodent he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc63ea76acacbd7c958839b550350fc7
http://europepmc.org/articles/PMC4303521
http://europepmc.org/articles/PMC4303521
Autor:
Grace Patlewicz, Louis Anthony Cox, J. Craig Rowlands, Richard A. Becker, M. Sue Marty, Katy O. Goyak, Douglas A. Popken
Publikováno v:
Regulatory Toxicology and Pharmacology. 69(3):443-450
High throughput (HTS) and high content (HCS) screening methods show great promise in changing how hazard and risk assessments are undertaken, but scientific confidence in such methods and associated prediction models needs to be established prior to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350fbfee062659127b067369aaba29b3
Autor:
A. Aziz Aboobaker, J. Craig Rowlands, Simon V. Avery, David R. Bell, Martin Rose, Sunir Malla, Abeer H. A. Amer, Richard J. Wall, Ian R. Mellor, Fei Sang, Timothy W. Gant
Publikováno v:
Toxicol. Res.. 3:315-323
The mechanisms regulating the induction of hepatic DNA synthesis by PPARα agonists are currently incompletely understood, and we set out to determine whether there are different mechanisms of induction for PPARα agonists and other hepatic growth ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c49926c18015bdea1ed1da35e59e90f5
https://doi.org/10.1039/c3tx50110h
https://doi.org/10.1039/c3tx50110h
Autor:
Alan A. Dombkowski, Michael B. Black, J. Craig Rowlands, Robert A. Budinsky, Daniela Cukovic, Russell D. Wolfinger, Russell S. Thomas, Chad M. Thompson, B. Bhaskar Gollapudi, Jonathan D. Urban
Publikováno v:
Toxicological Sciences. 136:595-604
Toxic equivalency factors (TEFs) for dioxin-like compounds are largely based on relative potency (REP) values derived from biochemical endpoints such as enzyme activity. As of yet, REPs based on gene expression changes have not been accounted for in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a48e96024cbf7bfee3ac58ee867abf
https://doi.org/10.1093/toxsci/kft203
https://doi.org/10.1093/toxsci/kft203
Autor:
Shawna D’Ingillo, Russell S. Thomas, Natalia Kovalova, Anthony Bach, Joshua A. Harrill, Jinpeng Li, J. Craig Rowlands, Norbert E. Kaminski, Ashwini S. Phadnis-Moghe, Jose E. Suarez-Martinez, Robert A. Budinsky, Robert B. Crawford, Weimin Chen, Barbara L. F. Kaplan
Publikováno v:
Toxicology.
The aryl hydrocarbon receptor (AHR) has been extensively characterized for the essential role it plays in mediating the toxic responses elicited by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Despite similarities across animal species, species-specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f127af1bef35f7c0a7e47a20c5c23167
https://pubmed.ncbi.nlm.nih.gov/27590929
https://pubmed.ncbi.nlm.nih.gov/27590929
Autor:
David R. Bell, Cenzo Congiu, Michael S. Denison, Ian R. Mellor, Guochun He, Alwyn Fernandes, J. Craig Rowlands, Richard J. Wall, Valentina Onnis, Gianfranco Balboni, Martin Rose
Publikováno v:
University of Manchester-PURE
The Aryl hydrocarbon receptor (AhR) mediates the induction of a variety of xenobiotic metabolism genes. Activation of the AhR occurs through binding to a group of structurally diverse compounds, most notably dioxins, which are exogenous ligands. Isof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36fef33afe74d54df33b36d06f1d26d2
https://doi.org/10.1016/j.tox.2012.03.011
https://doi.org/10.1016/j.tox.2012.03.011
Autor:
Alan A. Dombkowski, Russell S. Thomas, Stephen S. Ferguson, Daniela Cukovic, J. Craig Rowlands, Michael B. Black, Edward L. LeCluyse, Robert A. Budinsky
Publikováno v:
Toxicological Sciences. 127:199-215
A toxicogenomics approach was used to qualitatively and quantitatively compare the gene expression changes in human and rat primary hepatocytes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Hepatocytes from five individual rats and five indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c1be429b39d7cee9761251689cf664
https://doi.org/10.1093/toxsci/kfs069
https://doi.org/10.1093/toxsci/kfs069