Zobrazeno 1 - 10
of 2 073
pro vyhledávání: '"J Conboy"'
Autor:
Daehwan Kim, Subin Kim, Ashley Sung, Neetika Patel, Nathan Wong, Michael J. Conboy, Irina M. Conboy
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-19 (2022)
Abstract Background Amyotrophic lateral sclerosis (ALS) is characterized by a progressive loss of motor neurons (MNs), leading to paralysis, respiratory failure and death within 2–5 years of diagnosis. The exact mechanisms of sporadic ALS, which co
Externí odkaz:
https://doaj.org/article/9530e15f8fb64e31801ab8652148748f
Autor:
Michael J. Conboy, Irina M. Conboy, Etsuko Watanabe, Chao Liu, Regina Rohe, Jan C. Hoffman, Ahvie Herskowitz, Dobri D. Kiprov, Michael Lieb, Daehwan Kim
Publikováno v:
F1000Research, Vol 10 (2022)
Many patients with COVID-19 experience a range of debilitating symptoms months after being infected, a syndrome termed long-haul COVID. A 68-year-old male presented with lung opacity, fatigue, physical and cognitive weaknesses, loss of smell and lymp
Externí odkaz:
https://doaj.org/article/568c2b59649e4609b8bd4dd33f929a11
Publikováno v:
Skeletal Muscle, Vol 10, Iss 1, Pp 1-16 (2020)
Abstract Skeletal muscle is among the most age-sensitive tissues in mammal organisms. Significant changes in its resident stem cells (i.e., satellite cells, SCs), differentiated cells (i.e., myofibers), and extracellular matrix cause a decline in tis
Externí odkaz:
https://doaj.org/article/4900ae326d2b4794a49616780a2cf7f3
Application of bio-orthogonal proteome labeling to cell transplantation and heterochronic parabiosis
Autor:
Yan Liu, Michael J. Conboy, Melod Mehdipour, Yutong Liu, Thanhtra P. Tran, Aaron Blotnick, Prasanna Rajan, Thalie Cavalcante Santos, Irina M. Conboy
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Clarifying the source of proteins in mixed biological environments, such as after transplantation or parabiosis, remains a challenge. Here, the authors address this need with a mouse strain that incorporates a methionine derivate into proteins, allow
Externí odkaz:
https://doaj.org/article/593aea7e7dad473e959a3dab060fdf57
Autor:
Daehwan Kim, Dobri D. Kiprov, Connor Luellen, Michael Lieb, Chao Liu, Etsuko Watanabe, Xiaoyue Mei, Kaitlin Cassaleto, Joel Kramer, Michael J. Conboy, Irina M. Conboy
Publikováno v:
GeroScience. 44:2701-2720
Abstract This work extrapolates to humans the previous animal studies on blood heterochronicity and establishes a novel direct measurement of biological age. Our results support the hypothesis that, similar to mice, human aging is driven by age-impos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babf387ba2fd66dac689a3ad01f017b3
https://doi.org/10.1007/s11357-022-00645-w
https://doi.org/10.1007/s11357-022-00645-w
Autor:
Chao Liu, Nathan Wong, Etsuko Watanabe, William Hou, Leonardo Biral, Jonalyn DeCastro, Melod Mehdipour, Kiana Aran, Michael J. Conboy, Irina M. Conboy
Publikováno v:
Rejuvenation research, vol 25, iss 2
Rejuvenation Res
Rejuvenation Res
Metabolic proteomics has been widely used to characterize dynamic protein networks in many areas of biomedicine, including in the arena of tissue aging and rejuvenation. Bioorthogonal noncanonical amino acid tagging (BONCAT) is based on mutant methio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9cf3231ec42614bc861c498340cd872
https://doi.org/10.1089/rej.2022.0019
https://doi.org/10.1089/rej.2022.0019
Autor:
Jonalyn DeCastro, Joshua Littig, Peichi Peggy Chou, Jada Mack-Onyeike, Amrita Srinivasan, Michael J. Conboy, Irina M. Conboy, Kiana Aran
Publikováno v:
Molecules, Vol 26, Iss 3, p 535 (2021)
As the fields of aging and neurological disease expand to liquid biopsies, there is a need to identify informative biomarkers for the diagnosis of neurodegeneration and other age-related disorders such as cancers. A means of high-throughput screening
Externí odkaz:
https://doaj.org/article/30aa4109c1bc4486a3f0a314619390af
Autor:
Justin Rebo, Melod Mehdipour, Ranveer Gathwala, Keith Causey, Yan Liu, Michael J. Conboy, Irina M. Conboy
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Joining the circulatory system of an old with a young animal has been shown to rejuvenate old tissues. Here the authors describe a comparatively simple blood infusion system that allows for the controlled exchange of blood between two animals, and st
Externí odkaz:
https://doaj.org/article/ce9ad771dce64638b95c9e99bc8115df
Autor:
Yan Liu, Michael J. Conboy, Melod Mehdipour, Yutong Liu, Thanhtra P. Tran, Aaron Blotnick, Prasanna Rajan, Thalie Cavalcante Santos, Irina M. Conboy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/43520becfc814e78b0f77ac898c1afb6
Autor:
Melod Mehdipour, Payam Amiri, Chao Liu, Jonalyn DeCastro, Cameron Kato, Colin M. Skinner, Michael J. Conboy, Kiana Aran, Irina M. Conboy
Publikováno v:
Nature protocols, vol 17, iss 11
Nat Protoc
Nat Protoc
We describe a small-animal blood exchange approach developed for aging research as an alternative to heterochronic parabiosis or plasma injections. In parabiosis, animals are surgically coupled, which has several disadvantages, including difficulty c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe2d1fea41411b74118880d22fd5ef5
https://escholarship.org/uc/item/1c52m9gj
https://escholarship.org/uc/item/1c52m9gj
