Zobrazeno 1 - 10
of 276
pro vyhledávání: '"J Christopher, Love"'
Autor:
Duncan M. Morgan, Yiming J. Zhang, Jin-Hwan Kim, MaryAnn Murillo, Suddham Singh, Jakob Loschko, Naveen Surendran, Ognjen Sekulovic, Ellie Feng, Shuting Shi, Darrell J. Irvine, Sarita U. Patil, Isis Kanevsky, Laurent Chorro, J. Christopher Love
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-18 (2024)
Abstract Single-cell RNA sequencing (scRNA-seq) can resolve transcriptional features from individual cells, but scRNA-seq techniques capable of resolving the variable regions of B cell receptors (BCRs) remain limited, especially from widely-used 3′
Externí odkaz:
https://doaj.org/article/3918307e4fee4f74bea9a50c8f7927b6
Autor:
Neil C. Dalvie, Timothy R. Lorgeree, Yuchen Yang, Sergio A. Rodriguez-Aponte, Charles A. Whittaker, Joshua A. Hinckley, John J. Clark, Amanda M. Del Rosario, Kerry R. Love, J. Christopher Love
Publikováno v:
Microbial Cell Factories, Vol 23, Iss 1, Pp 1-10 (2024)
Abstract Background The yeast Komagataella phaffii is widely used for manufacturing recombinant proteins, but secreted titers of recombinant proteins could be improved by genetic engineering. In this study, we hypothesized that cellular resources cou
Externí odkaz:
https://doaj.org/article/85999b86316148c5b7e4f35b9ac6ca09
Autor:
Ho-Joon Lee, Yujiao Zhao, Ira Fleming, Sameet Mehta, Xiaomei Wang, Brent Vander Wyk, Shannon E. Ronca, Heather Kang, Chih-Hung Chou, Benoit Fatou, Kinga K. Smolen, Ofer Levy, Clary B. Clish, Ramnik J. Xavier, Hanno Steen, David A. Hafler, J. Christopher Love, Alex K. Shalek, Leying Guan, Kristy O. Murray, Steven H. Kleinstein, Ruth R. Montgomery
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108387- (2023)
Summary: Infection with West Nile virus (WNV) drives a wide range of responses, from asymptomatic to flu-like symptoms/fever or severe cases of encephalitis and death. To identify cellular and molecular signatures distinguishing WNV severity, we empl
Externí odkaz:
https://doaj.org/article/22004309d1e84b60bb1a70a582178024
Autor:
Stefani Spranger, Duncan Morgan, Vidit Bhandarkar, Teresa Dinter, Lorelai Pop, Emi A Lutz, K Dane Wittrup, J Christopher Love
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/41fff98a5033441f91c62d9827421db7
Autor:
Neil C. Dalvie, Christopher A. Naranjo, Sergio A. Rodriguez-Aponte, Ryan S. Johnston, J. Christopher Love
Publikováno v:
Microbial Cell Factories, Vol 21, Iss 1, Pp 1-11 (2022)
Abstract Background Komagataella phaffii is a commonly used alternative host for manufacturing therapeutic proteins, in part because of its ability to secrete recombinant proteins into the extracellular space. Incorrect processing of secreted protein
Externí odkaz:
https://doaj.org/article/fe5f46864deb41008b8adbcc78977c74
Autor:
Gaurav Nagar, Siddharth Jain, Meghraj Rajurkar, Rakesh Lothe, Harish Rao, Sourav Majumdar, Manish Gautam, Sergio A. Rodriguez-Aponte, Laura E. Crowell, J. Christopher Love, Prajakta Dandekar, Amita Puranik, Sunil Gairola, Umesh Shaligram, Ratnesh Jain
Publikováno v:
Vaccines, Vol 11, Iss 10, p 1602 (2023)
SARS-CoV-2 spike protein is an essential component of numerous protein-based vaccines for COVID-19. The receptor-binding domain of this spike protein is a promising antigen with ease of expression in microbial hosts and scalability at comparatively l
Externí odkaz:
https://doaj.org/article/803238a4a29446febff56c33b9a18df2
Autor:
Nicole A. LaHood, Jungki Min, Tarun Keswani, Crystal M. Richardson, Kwasi Amoako, Jingjia Zhou, Orlee Marini-Rapoport, Hervé Bernard, Stéphane Hazebrouck, Wayne G. Shreffler, J. Christopher Love, Anna Pomes, Lars C. Pedersen, Geoffrey A. Mueller, Sarita U. Patil
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 2 (2023)
In IgE-mediated food allergies, exposure to the allergen activates systemic allergic responses. Oral immunotherapy (OIT) treats food allergies through incremental increases in oral allergen exposure. However, OIT only induces sustained clinical toler
Externí odkaz:
https://doaj.org/article/63cc0678fb644582a854e06feafb31df
Autor:
Gat Rauner, Dexter X. Jin, Daniel H. Miller, Todd M. Gierahn, Carman M. Li, Ethan S. Sokol, Yu-Xiong Feng, Robert A. Mathis, J. Christopher Love, Piyush B. Gupta, Charlotte Kuperwasser
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Mammary morphogenesis is a complex process. Here the authors describe how stem cells build a three-dimensional self-organizing multi-lineage tissue by showing that positional signals from the extracellular matrix through the collagen receptor DDR1 le
Externí odkaz:
https://doaj.org/article/14b6186190b543a5aaf0be800b9bd67a
Autor:
Hao D. Cheng, Karen G. Dowell, Chris Bailey-Kellogg, Brittany A. Goods, J. Christopher Love, Guido Ferrari, Galit Alter, Johannes Gach, Donald N. Forthal, George K. Lewis, Kelli Greene, Hongmei Gao, David C. Montefiori, Margaret E. Ackerman
Publikováno v:
Retrovirology, Vol 18, Iss 1, Pp 1-12 (2021)
Abstract Background The critical role of antibody Fc-mediated effector functions in immune defense has been widely reported in various viral infections. These effector functions confer cellular responses through engagement with innate immune cells. T
Externí odkaz:
https://doaj.org/article/4235d5a3572a4412a0a847e70b2a85c9
Autor:
Sakshi Bajoria, Kawaljit Kaur, Ozan S. Kumru, Greta Van Slyke, Jennifer Doering, Hayley Novak, Sergio A. Rodriguez Aponte, Neil C. Dalvie, Christopher A. Naranjo, Ryan S. Johnston, Judith Maxwell Silverman, Harry Kleanthous, J. Christopher Love, Nicholas J. Mantis, Sangeeta B. Joshi, David B. Volkin
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 18, Iss 5 (2022)
Low-cost, refrigerator-stable COVID-19 vaccines will facilitate global access and improve vaccine coverage in low- and middle-income countries. To this end, subunit-based approaches targeting the receptor-binding domain (RBD) of SARS-CoV-2 Spike prot
Externí odkaz:
https://doaj.org/article/35022f23ff944bc2b948e4fb228bed37