Zobrazeno 1 - 10
of 82
pro vyhledávání: '"J Charles Whitbeck"'
Autor:
J Charles Whitbeck, Anu Thomas, Kathryn Kadash-Edmondson, Ariadna Grinyo-Escuer, Lewis J Stafford, Celine Cheng, Grant C Liao, Frederick W Holtsberg, M Javad Aman, Graham Simmons, Edgar Davidson, Benjamin J Doranz
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 11, p e0008730 (2020)
The development of vaccines against flaviviruses, including Zika virus (ZIKV) and dengue virus (DENV), continues to be a major challenge, hindered by the lack of efficient and reliable methods for screening neutralizing activity of sera or antibodies
Externí odkaz:
https://doaj.org/article/c7e7952329a2425385d3c09278e4276d
Autor:
Yi Zuo, J Charles Whitbeck, Gabriel J Haila, Abraham A Hakim, Paul W Rothlauf, Roselyn J Eisenberg, Gary H Cohen, Claude Krummenacher
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223299 (2019)
Oral herpes is a highly prevalent infection caused by herpes simplex virus 1 (HSV-1). After an initial infection of the oral cavity, HSV-1 remains latent in sensory neurons of the trigeminal ganglia. Episodic reactivation of the virus leads to the fo
Externí odkaz:
https://doaj.org/article/19b45f6d1c2c4508a3b21aa8a313aa93
Autor:
John R Gallagher, Doina Atanasiu, Wan Ting Saw, Matthew J Paradisgarten, J Charles Whitbeck, Roselyn J Eisenberg, Gary H Cohen
Publikováno v:
PLoS Pathogens, Vol 10, Iss 9, p e1004373 (2014)
Entry of herpes simplex virus (HSV) into a target cell requires complex interactions and conformational changes by viral glycoproteins gD, gH/gL, and gB. During viral entry, gB transitions from a prefusion to a postfusion conformation, driving fusion
Externí odkaz:
https://doaj.org/article/113c476b29574b099e98dc306dff71fb
Autor:
Edgar Davidson, J. Charles Whitbeck, M. Javad Aman, Graham Simmons, Lewis J. Stafford, Kathryn Kadash-Edmondson, Benjamin J. Doranz, Ariadna Grinyo-Escuer, Anu Thomas, Frederick W. Holtsberg, Grant C. Liao, Celine Cheng
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 11, p e0008730 (2020)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
The development of vaccines against flaviviruses, including Zika virus (ZIKV) and dengue virus (DENV), continues to be a major challenge, hindered by the lack of efficient and reliable methods for screening neutralizing activity of sera or antibodies
Autor:
Claude Krummenacher, J. Charles Whitbeck, Wan Ting Saw, Lucas Bennett, Tina M. Cairns, Chun Wu, Benjamin D. Brooks, Roselyn J. Eisenberg, Doina Atanasiu, Noah Ditto, Huan Lou, Birgitte Bruun, Helena Browne, Gary H. Cohen
Publikováno v:
J Virol
A cascade of protein-protein interactions between four herpes simplex virus (HSV) glycoproteins (gD, gH/gL, and gB) drive fusion between the HSV envelope and host membrane, thereby allowing for virus entry and infection. Specifically, binding of gD t
Autor:
Benjamin J. Doranz, Frederick W. Holtsberg, J. Charles Whitbeck, Kathryn Kadash-Edmondson, Anu Thomas, Grant C. Liao, Celine Cheng, Edgar Davidson, M. Javad Aman, Ariadna Grinyo i Escuer, Graham Simmons
The development of vaccines against flaviviruses, including Zika virus (ZIKV) and dengue virus (DENV), continues to be a major challenge, hindered by the lack of efficient and reliable methods for screening neutralizing activity of sera or antibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d38ec8185759f66963a383184a3252
https://doi.org/10.1101/2020.04.21.047241
https://doi.org/10.1101/2020.04.21.047241
Autor:
Paul W. Rothlauf, J. Charles Whitbeck, Abraham Hakim, Yi Zuo, Gabriel J. Haila, Roselyn J. Eisenberg, Claude Krummenacher, Gary H. Cohen
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0223299 (2019)
PLoS ONE
PLoS ONE
Oral herpes is a highly prevalent infection caused by herpes simplex virus 1 (HSV-1). After an initial infection of the oral cavity, HSV-1 remains latent in sensory neurons of the trigeminal ganglia. Episodic reactivation of the virus leads to the fo
Autor:
Roselyn J. Eisenberg, Tina M. Cairns, Wan Ting Saw, J. Charles Whitbeck, Huan Lou, Eric Lazear, Doina Atanasiu, Gary H. Cohen
HSV virus-cell and cell-cell fusion requires multiple interactions between four essential virion envelope glycoproteins, gD, gB, gH, and gL, and between gD and a cellular receptor, nectin-1 or herpesvirus entry mediator (HVEM). Current models suggest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0bc86a4f6959483b5e1aad25644788
https://europepmc.org/articles/PMC6258950/
https://europepmc.org/articles/PMC6258950/
Autor:
Juan Fontana, Doina Atanasiu, Wan Ting Saw, John R. Gallagher, Reagan G. Cox, J. Charles Whitbeck, Lauren M. Brown, Roselyn J. Eisenberg, Gary H. Cohen, Anne Moscona
Publikováno v:
mBio, Vol 8, Iss 4, p e01268-17 (2017)
All enveloped viruses, including herpesviruses, must fuse their envelope with the host membrane to deliver their genomes into target cells, making this essential step subject to interference by antibodies and drugs. Viral fusion is mediated by a vira
Autor:
Chwan Hong Foo, Huan Lou, Roselyn J. Eisenberg, Doina Atanasiu, Manuel Ponce-de-Leon, J. Charles Whitbeck, Gary H. Cohen
Publikováno v:
Virology. 385(2):368-382
L1 and A28 are vaccinia virus (VACV) envelope proteins which are essential for cellular entry. However, their specific roles during entry are unknown. We tested whether one or both of these proteins might serve as receptor binding proteins (RBP). We