Zobrazeno 1 - 10
of 321
pro vyhledávání: '"J Capobianco"'
Autor:
Giulia Diluvio, Tanya T. Kelley, Mohini Lahiry, Annamil Alvarez-Trotta, Ellen M. Kolb, Elena Shersher, Luisana Astudillo, Rhett A. Kovall, Stephan C. Schürer, Anthony J. Capobianco
Publikováno v:
Molecular Therapy: Oncolytics, Vol 28, Iss , Pp 307-320 (2023)
Notch activation complex kinase (NACK) is a component of the Notch transcriptional machinery critical for the Notch-mediated tumorigenesis. However, the mechanism through which NACK regulates Notch-mediated transcription is not well understood. Here,
Externí odkaz:
https://doaj.org/article/b1e16d1d943d4b45b5719482002cf0ad
Autor:
Elena Shersher, Mohini Lahiry, Annamil Alvarez-Trotta, Giulia Diluvio, David J. Robbins, Ramin Shiekhattar, Anthony J. Capobianco
Publikováno v:
Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-12 (2021)
Abstract Background Notch signaling drives many aspects of neoplastic phenotype. Here, we report that the Integrator complex (INT) is a new component of the Notch transcriptional supercomplex. Together with Notch Activation Complex Kinase (NACK), INT
Externí odkaz:
https://doaj.org/article/587cc34a5374465a8828e19dd94d6a1d
Autor:
Chen Shen, Anmada Nayak, Leif R. Neitzel, Amber A. Adams, Maya Silver-Isenstadt, Leah M. Sawyer, Hassina Benchabane, Huilan Wang, Nawat Bunnag, Bin Li, Daniel T. Wynn, Fan Yang, Marta Garcia-Contreras, Charles H. Williams, Sivanesan Dakshanamurthy, Charles C. Hong, Nagi G. Ayad, Anthony J. Capobianco, Yashi Ahmed, Ethan Lee, David J. Robbins
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Cereblon (CRBN) is an E3 ubiquitin ligase substrate receptor that is involved in cancer cell death, although its regulation is poorly understood. Here, the authors show that Wnt ligand increases CRBN-dependent protein degradation and demonstrate CRBN
Externí odkaz:
https://doaj.org/article/b0213d02bb5e42d487d2f5912805e034
Autor:
Emily F. Winterbottom, Yuguang Ban, Xiaodian Sun, Anthony J. Capobianco, Carmen J. Marsit, Xi Chen, Lily Wang, Margaret R. Karagas, David J. Robbins
Publikováno v:
Environmental Health, Vol 18, Iss 1, Pp 1-10 (2019)
Abstract Background Increasing evidence suggests that prenatal exposure to arsenic, even at common environmental levels, adversely affects child health. These adverse effects include impaired fetal growth, which can carry serious health implications
Externí odkaz:
https://doaj.org/article/8763ead5b33d44bb8e08327053421c6f
Autor:
Emily F. Winterbottom, Yuka Moroishi, Yuliya Halchenko, David A. Armstrong, Paul J. Beach, Quang P. Nguyen, Anthony J. Capobianco, Nagi G. Ayad, Carmen J. Marsit, Zhigang Li, Margaret R. Karagas, David J. Robbins
Publikováno v:
Environmental Health, Vol 18, Iss 1, Pp 1-8 (2019)
Abstract Background Prenatal exposure to arsenic has been linked to a range of adverse health conditions in later life. Such fetal origins of disease are frequently the result of environmental effects on the epigenome, leading to long-term alteration
Externí odkaz:
https://doaj.org/article/2397f3474426484ba5da5de068d8358a
Autor:
Emily F. Winterbottom, Devin C. Koestler, Dennis Liang Fei, Eric Wika, Anthony J. Capobianco, Carmen J. Marsit, Margaret R. Karagas, David J. Robbins
Publikováno v:
Environmental Health, Vol 16, Iss 1, Pp 1-9 (2017)
Abstract Background Sex-specific factors play a major role in human health and disease, including responses to environmental stresses such as toxicant exposure. Increasing evidence suggests that such sex differences also exist during fetal developmen
Externí odkaz:
https://doaj.org/article/2fd35b02983a4639922d99b0ae8e2afc
Autor:
Fan Yang, Jezabel Rodriguez-Blanco, Jun Long, Marzena Swiderska-Syn, Daniel T. Wynn, Bin Li, Chen Shen, Anmada Nayak, Yuguang Ban, Xiaodian Sun, Robert K. Suter, Heather J. McCrea, Anthony J. Capobianco, Nagi G. Ayad, David J. Robbins
Publikováno v:
Mol Cancer Res
Dysregulation of Sonic hedgehog (SHH) signaling drives the growth of distinct cancer subtypes, including medulloblastoma (MB). Such cancers have been treated in the clinic with a number of clinically relevant SHH inhibitors, the majority of which tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b886eaf99c9926d3d2d4bffeb85855
https://doi.org/10.1158/1541-7786.mcr-22-0182
https://doi.org/10.1158/1541-7786.mcr-22-0182
Autor:
David J. Robbins, Nagi G. Ayad, Anthony J. Capobianco, Heather J. McCrea, Robert K. Suter, Xiaodian Sun, Yuguang Ban, Anmada Nayak, Chen Shen, Bin Li, Daniel T. Wynn, Marzena Swiderska-Syn, Jun Long, Jezabel Rodriguez-Blanco, Fan Yang
Supplementary Figure from A Druggable UHRF1/DNMT1/GLI Complex Regulates Sonic Hedgehog–Dependent Tumor Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10389b39f7c2504b80af45872eabbf86
https://doi.org/10.1158/1541-7786.22527851.v1
https://doi.org/10.1158/1541-7786.22527851.v1
Autor:
Matthew R. Broadus, Tony W. Chen, Leif R. Neitzel, Victoria H. Ng, Jeanne N. Jodoin, Laura A. Lee, Adrian Salic, David J. Robbins, Anthony J. Capobianco, James G. Patton, Stacey S. Huppert, Ethan Lee
Publikováno v:
Cell Reports, Vol 15, Iss 9, Pp 1920-1929 (2016)
Upon Notch pathway activation, the receptor is cleaved to release the Notch intracellular domain (NICD), which translocates to the nucleus to activate gene transcription. Using Xenopus egg extracts, we have identified a Notch1-specific destruction si
Externí odkaz:
https://doaj.org/article/a8e1a0d542cf427ea9b1cfd4d896a30d
Autor:
Anthony J. Capobianco, Darren Orton, David J. Robbins, Hugo Kaneku, Elena Shersher, Giulia Diluvio, Mohini Lahiry, Luisana Astudillo, William Guerrant, Annamil Alvarez-Trotta
Off target profiling of NADI-351
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20847622067128fca982016a14cbdc6a
https://doi.org/10.1158/0008-5472.22428331.v1
https://doi.org/10.1158/0008-5472.22428331.v1