Zobrazeno 1 - 10 of 569 pro vyhledávání: '"J CURIEL"'
1
Akademický článek
Tumour-intrinsic PDL1 signals regulate the Chk2 DNA damage response in cancer cells and mediate resistance to Chk1 inhibitors
Autor: Clare E. Murray, Anand V. R. Kornepati, Carlos Ontiveros, Yiji Liao, Bárbara de la Peña Avalos, Cody M. Rogers, Zexuan Liu, Yilun Deng, Haiyan Bai, Suresh Kari, Alvaro S. Padron, Jacob T. Boyd, Ryan Reyes, Curtis A. Clark, Robert S. Svatek, Rong Li, Yanfen Hu, Meiling Wang, José R. Conejo-Garcia, Lauren A. Byers, Kavya Ramkumar, Anil K. Sood, Jung-Min Lee, Christin E. Burd, Ratna K. Vadlamudi, Harshita B. Gupta, Weixing Zhao, Eloïse Dray, Patrick Sung, Tyler J. Curiel
Publikováno v: Molecular Cancer, Vol 23, Iss 1, Pp 1-24 (2024)
Abstract Background Aside from the canonical role of PDL1 as a tumour surface-expressed immune checkpoint molecule, tumour-intrinsic PDL1 signals regulate non-canonical immunopathological pathways mediating treatment resistance whose significance, me
Externí odkaz: https://doaj.org/article/324b033e9fa34bbcab45721b8054a03a
Zobrazit plný text záznamu
2
Akademický článek
Immune checkpoint expression and relationships to anti‐PD‐L1 immune checkpoint blockade cancer immunotherapy efficacy in aged versus young mice
Autor: Myrna G. Garcia, Yilun Deng, Clare Murray, Ryan M Reyes, Alvaro Padron, Haiyan Bai, Aravind Kancharla, Harshita Gupta, Shai Shen‐Orr, Tyler J. Curiel
Publikováno v: Aging and Cancer, Vol 3, Iss 1, Pp 68-83 (2022)
Abstract Introduction Aging is the biggest cancer risk, and immune checkpoint (IC) inhibition (ICI) is a revolutionary cancer immunotherapy approach. Nonetheless, there are limited preclinical/clinical data regarding aging effects on ICI outcomes or
Externí odkaz: https://doaj.org/article/6e38dcc7219a4ad18d7bf224e2f30b37
Zobrazit plný text záznamu
3
Akademický článek
Bladder cancer cell‐intrinsic PD‐L1 signals promote mTOR and autophagy activation that can be inhibited to improve cytotoxic chemotherapy
Autor: Deyi Zhang, Ryan M. Reyes, Erica Osta, Suresh Kari, Harshita B. Gupta, Alvaro S. Padron, Anand V. R. Kornepati, Aravind Kancharla, Xiujie Sun, Yilun Deng, Bogang Wu, Ratna Vadlamudi, Rong Li, Robert S. Svatek, Tyler J. Curiel
Publikováno v: Cancer Medicine, Vol 10, Iss 6, Pp 2137-2152 (2021)
Abstract Tumor cell‐intrinsic programmed death‐ligand 1 (PD‐L1) signals mediate immunopathologic effects in breast, colon, and ovarian cancers and in melanomas, but bladder cancer (BC) effects are unreported. We show here that BC cell‐intrins
Externí odkaz: https://doaj.org/article/e4a5d1a873db407eb7004100b7129f12
Zobrazit plný text záznamu
4
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
6
Akademický článek
Rapamycin enhances BCG-specific γδ T cells during intravesical BCG therapy for non-muscle invasive bladder cancer: a randomized, double-blind study
Autor: Niannian Ji, Neelam Mukherjee, Tyler J Curiel, Ryan M Reyes, Jonathan Gelfond, Martin Javors, Joshua J. Meeks, David J McConkey, Zhen-Ju Shu, Chethan Ramamurthy, Ryan Dennett, Robert S Svatek
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Background Although intravesical BCG is the standard treatment of high-grade non-muscle invasive bladder cancer (NMIBC), response rates remain unsatisfactory. In preclinical models, rapamycin enhances BCG vaccine efficacy against tuberculosis and the
Externí odkaz: https://doaj.org/article/8727334813974223b8ab1c8584e1818e
Zobrazit plný text záznamu
7
Akademický článek
Estrogen receptor beta signaling in CD8+ T cells boosts T cell receptor activation and antitumor immunity through a phosphotyrosine switch
Autor: Jing Yang, Rong Li, Bin Yuan, Curtis A Clark, Bogang Wu, Justin M Drerup, Tianbao Li, Victor X Jin, Yanfen Hu, Tyler J Curiel
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
BackgroundThe non-overlapping functions of the two estrogen receptor subtypes, ERα (Estrogen Receptor α)and ERβ (Estrogen Receptor β), in tumor cells have been studied extensively. However, their counterparts in host cells is vastly underinterrog
Externí odkaz: https://doaj.org/article/9a99bc7f4fa646ec8701df65ded1023e
Zobrazit plný text záznamu
8
Akademický článek
CD122-targeted interleukin-2 and αPD-L1 treat bladder cancer and melanoma via distinct mechanisms, including CD122-driven natural killer cell maturation
Autor: Ryan M Reyes, Chenghao Zhang, Yilun Deng, Niannian Ji, Neelam Mukherjee, Alvaro S Padron, Curtis A Clark, Robert S Svatek, Tyler J Curiel
Publikováno v: OncoImmunology, Vol 10, Iss 1 (2021)
Bladder cancer (BC) and melanoma are amenable to immune checkpoint blockade (ICB) therapy, yet most patients with advanced/metastatic disease do not respond. CD122-targeted interleukin (IL)-2 can improve ICB efficacy, but mechanisms are unclear. We t
Externí odkaz: https://doaj.org/article/6f57b3a6ecf3451ead7b6bb61c301abc
Zobrazit plný text záznamu
10
Akademický článek
Genetic ablation of adipocyte PD-L1 reduces tumor growth but accentuates obesity-associated inflammation
Autor: Rong Li, Bin Yuan, Bogang Wu, Yanfen Hu, Tyler J Curiel, Huai-Chin Chiang, Xiujie Sun, Payal Mitra
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
The programmed death-ligand 1 (PD-L1)-dependent immune checkpoint attenuates host immunity and maintains self-tolerance. Imbalance between protective immunity and immunopathology due to altered PD-L1 signaling can lead to autoimmunity or tumor immuno
Externí odkaz: https://doaj.org/article/e4793b49487a45ad8664d5c4cfef8955
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje