Zobrazeno 1 - 10 of 26 pro vyhledávání: '"J C States"'
1
Differentially Expressed mRNA Targets of Differentially Expressed miRNAs Predict Changes in the TP53 Axis and Carcinogenesis-Related Pathways in Human Keratinocytes Chronically Exposed to Arsenic
Autor: J C States, Laila Al-Eryani, Samantha F. Jenkins, Chendil Damodaran, Ashish Tyagi, Sabine Waigel, Jana Peremartí
Publikováno v: Toxicological Sciences. 162:645-654
Arsenic is a widely distributed toxic natural element. Chronic arsenic ingestion causes several cancers, especially skin cancer. Arsenic-induced cancer mechanisms are not well defined, but several studies indicate that mutation is not the driving for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beedc736362e1912c994690a8bf6e2cb
https://doi.org/10.1093/toxsci/kfx292
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2
The DNA damage-recognition problem in human and other eukaryotic cells: the XPA damage binding protein
Autor: J E Cleaver, J C States
Publikováno v: Biochemical Journal. 328:1-12
The capacity of human and other eukaryotic cells to recognize a disparate variety of damaged sites in DNA, and selectively excise and repair them, resides in a deceptively small simple protein, a 38-42 kDa zinc-finger binding protein, XPA (xeroderma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::394f822631265dbd2db8381bb87e8b63
https://doi.org/10.1042/bj3280001
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3
Role of human CYP1A1 and NAT2 in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mutagenicity and DNA adducts
Autor: Jean Bendaly, Jason R. Neale, William M. Pierce, J. C. States, G. Jiang, J. L. Holloman, Mark A. Doll, David W. Hein, Kristin J. Metry, Ned B. Smith
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is carcinogenic in multiple organs and numerous species. Bioactivation of PhIP is initiated by PhIP N(2)-hydroxylation catalysed by cytochrome P450s. Following N-hydroxylation, O-acetylation cata
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b233471d8eba5d6c491732a0d73c32
https://europepmc.org/articles/PMC2789189/
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4
Abstract 212: Withaferin A in combination with cisplatin targets CD44 and Oct4 positive cancer stem cells in ovarian cancer
Autor: J C. States, Sham S. Kakar, Sanjay K. Singh
Publikováno v: Cancer Research. 74:212-212
Currently, the treatment for ovarian cancer entails cytoreductive surgery followed by chemotherapy, mainly, carboplatin coupled with paclitaxel. Although this treatment regimen is initially effective in a high percentage of cases, it is associated wi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3181f54a15009dc3cfbad4a4cb9bc16
https://doi.org/10.1158/1538-7445.am2014-212
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5
Sensitivity of myelomonocytic leukemia cells to arsenite-induced cell cycle disruption, apoptosis, and enhanced differentiation is dependent on the inter-relationship between arsenic concentration, duration of treatment, and cell cycle phase
Autor: M J, McCabe, K P, Singh, S A, Reddy, B, Chelladurai, J G, Pounds, J J, Reiners, J C, States
Publikováno v: The Journal of pharmacology and experimental therapeutics. 295(2)
Arsenite treatment has been found to induce clinical remission in patients with acute promyelocytic leukemia. Although the potential therapeutic value of arsenite may lie in triggering apoptosis, it has not been established that cytotoxicity is the s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::27bb9d8f3b524fe9e312cde99b96a165
https://pubmed.ncbi.nlm.nih.gov/11046111
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6
A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy
Autor: J E, Cleaver, L H, Thompson, A S, Richardson, J C, States
Publikováno v: Human mutation. 14(1)
The human diseases xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy are caused by mutations in a set of interacting gene products, which carry out the process of nucleotide excision repair. The majority of the genes have now been clo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::579f1551153064252936ec77825d8347
https://pubmed.ncbi.nlm.nih.gov/10447254
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7
Preferential DNA damage in the p53 gene by benzo[a]pyrene metabolites in cytochrome P4501A1-expressing xeroderma pigmentosum group A cells
Autor: T, Quan, J C, States
Publikováno v: Molecular carcinogenesis. 16(1)
Gene-specific DNA damage levels were determined by quantitative polymerase chain reaction (QPCR) after treating cytochrome P450 (CYP) 1A1-expressing xeroderma pigmentosum fibroblasts with [3H]benzo[a]pyrene-trans-7,8-dihydrodiol ([3H]BPD) or [3H]benz
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d7110ee82d8ddf2450eb9fe7ffd92584
https://pubmed.ncbi.nlm.nih.gov/8634092
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8
Mitogenic effects of tetrahydrobiopterin in PC12 cells
Autor: P Z, Anastasiadis, J C, States, B A, Imerman, M C, Louie, D M, Kuhn, R A, Levine
Publikováno v: Molecular pharmacology. 49(1)
(6R)-5,6,7,8-Tetrahydrobiopterin (BH4), which is synthesized intracellularly from GTP, caused a concentration-dependent increase in rat pheochromocytoma (PC12) cell proliferation when added exogenously. Incubation with sepiapterin, which is converted
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bb81d2f34b997cf661ba0f15001e3f25
https://pubmed.ncbi.nlm.nih.gov/8569700
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