Zobrazeno 1 - 10
of 23
pro vyhledávání: '"J C Hastings"'
Autor:
M E Davies, Joanne E. Tomassini, J S Tkacz, M Mojena, J C Hastings, Sheo B. Singh, Michael Goetz, S L Raghoobar, Russell B. Lingham
Publikováno v:
Antimicrobial Agents and Chemotherapy. 40:1189-1193
A novel anti-influenza virus compound, flutimide, was identified in extracts of a recently identified fungal species, Delitschia confertaspora (F. Pelaez, J.D. Polishook, M. Valldosera, and J.Guarro, Mycotaxon 50:115-122, 1994). The compound, a subst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f714fe5ce7e9b91e04631c382ab2c63
https://doi.org/10.1128/aac.40.5.1189
https://doi.org/10.1128/aac.40.5.1189
Autor:
J C Hastings, Robert L. Lafemina, Abigail Wolfe, Pia L. Graham, Emilio A. Emini, Daria J. Hazuda, H L Robbins
Publikováno v:
Journal of Biological Chemistry. 269:3999-4004
A DNA binding assay was developed for the human immunodeficiency virus type 1 (HIV-1) integrase. The assay was capable of defining discrete complexes between the enzyme and the viral long terminal repeat (LTR) substrate. DNA binding reflected the seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::526a554cd34633ec28fc83569f5724d2
https://doi.org/10.1016/s0021-9258(17)41733-9
https://doi.org/10.1016/s0021-9258(17)41733-9
Previous in vitro analyses have shown that the human immunodeficiency virus type 1 (HIV-1) integrase uses either manganese or magnesium to assemble as a stable complex on the donor substrate and to catalyze strand transfer. We now demonstrate that su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89df7fa7512ca9b91512d45e4d96716e
https://europepmc.org/articles/PMC191986/
https://europepmc.org/articles/PMC191986/
Publikováno v:
Drug design and discovery. 15(1)
An essential step in the replication of retroviruses is the integration of a DNA copy of the viral genome into the genome of the host cell. Integration encompasses a series of ordered endonucleolytic and DNA strand transfer reactions catalyzed by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79d227129e252ed137222d07a24789dc
https://pubmed.ncbi.nlm.nih.gov/9332828
https://pubmed.ncbi.nlm.nih.gov/9332828
Autor:
Daria J. Hazuda, D Grandgenett, K Brackmann, B Pramanik, J C Hastings, G Goodarzi, Abigail Wolfe, Peter J. Felock, A Vora
Publikováno v:
Journal of virology. 71(1)
In vitro assay systems which use recombinant retroviral integrase (IN) and short DNA oligonucleotides fail to recapitulate the full-site integration reaction as it is known to occur in vivo. The relevance of using such circumscribed in vitro assays t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0caf2be46e3b0814994cdd6678d09471
https://pubmed.ncbi.nlm.nih.gov/8985421
https://pubmed.ncbi.nlm.nih.gov/8985421
Publikováno v:
Antimicrobial agents and chemotherapy. 40(5)
We previously identified a series of compounds which specifically inhibited the transcription of influenza A and B viruses (J. Tomassini, H. Selnick, M.E. Davies, M.E. Armstrong, J. Baldwin, M. Bourgeois, J. Hastings, D. Hazuda, J. Lewis, W. McClemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acfd01bde05861fdff817b7a9298d7ee
https://pubmed.ncbi.nlm.nih.gov/8723491
https://pubmed.ncbi.nlm.nih.gov/8723491
Publikováno v:
Journal of virology. 70(3)
The integration of a DNA copy of the viral genome into the genome of the host cell is an essential step in the replication of all retroviruses. Integration requires two discrete biochemical reactions; specific processing of each viral long terminal r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a658882998b82f6a76447265ff3531eb
https://pubmed.ncbi.nlm.nih.gov/8627659
https://pubmed.ncbi.nlm.nih.gov/8627659
Autor:
J C Hastings, K LeGrow, Daria J. Hazuda, Pia L. Graham, Emilio A. Emini, Abigail Wolfe, Robert L. Lafemina, Steven D. Young
The human immunodeficiency virus type 1 (HIV-1) integrase protein is required for the productive infection of T-lymphoid cells in culture (R. L. LaFemina, C. L. Schneider, H. L. Robbins, P. L. Callahan, K. LeGrow, E. Roth, W. A. Schleif, and E. A. Em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca5afab88fde0564ce80c40ba17e337
https://europepmc.org/articles/PMC162534/
https://europepmc.org/articles/PMC162534/
Autor:
John A. Lewis, M E Davies, Mcclements William L, Harold G. Selnick, M Bourgeois, J C Hastings, M. E. Armstrong, Joanne E. Tomassini, J. Baldwin, Daria J. Hazuda
Synthesis of influenza virus mRNA is primed by capped and methylated (cap 1, m7GpppXm) RNAs which the virus derives by endonucleolytic cleavage from RNA polymerase II transcripts in host cells. The conserved nature of the endonucleolytic processing p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251847ccbd92d754731e807e6d1c214b
https://europepmc.org/articles/PMC188292/
https://europepmc.org/articles/PMC188292/
Publikováno v:
The Journal of biological chemistry. 269(6)
A DNA binding assay was developed for the human immunodeficiency virus type 1 (HIV-1) integrase. The assay was capable of defining discrete complexes between the enzyme and the viral long terminal repeat (LTR) substrate. DNA binding reflected the seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5167974e15e7358498a5dae115a39c7c
https://pubmed.ncbi.nlm.nih.gov/8307956
https://pubmed.ncbi.nlm.nih.gov/8307956