Zobrazeno 1 - 10
of 12
pro vyhledávání: '"J C Downing"'
Autor:
Denise Coluccio, Erik Rasmussen, J C Downing, Joel Estis, Igor Mikaelian, John A. Todd, Quynh Anh Lu, Rosemary Nicklaus, Gerard Hirkaler
Publikováno v:
Toxicologic Pathology. 37:878-881
The purpose of this study was to correlate the histologic changes in the heart to serum cardiac troponin I (cTnI) concentrations assayed with the Erenna Immunoassay System in Wistar rats (Crl:Wi[Han]) using the hydralazine model of cardiotoxicity. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99aa21732fe55dd427485b0bb33ab2bc
https://doi.org/10.1177/0192623309351894
https://doi.org/10.1177/0192623309351894
Autor:
James F. Powers, Panayiotis Tsokas, J C Downing, R.M. McClain, Arthur S. Tischler, M Pignatello
Publikováno v:
Toxicological Sciences. 51:9-18
Adrenal medullary hyperplasia and pheochromocytomas are induced in rats by a variety of non-genotoxic agents, and we have hypothesized that these agents induce lesions indirectly by stimulating chromaffin cell proliferation. Vitamin D3, which has not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b8d98437d565c2a63fcadd7e3bb3b0
https://doi.org/10.1093/toxsci/51.1.9
https://doi.org/10.1093/toxsci/51.1.9
Autor:
J C Downing, Mehzad Shahsavari, Arthur S. Tischler, R. Michael McClain, Panayiotis Tsokas, James F. Powers, Jeffrey Ziar
Publikováno v:
Fundamental and Applied Toxicology. 35:216-220
Spontaneous and drug-induced pheochromocytomas are common in rats and rare in mice. The antihypertensive drug reserpine has been shown to both induce pheochromocytomas and stimulate chromaffin cell proliferation in rats, leading to the hypothesis tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e18a75ff3639d684aca26c901d285fc
https://doi.org/10.1006/faat.1996.2277
https://doi.org/10.1006/faat.1996.2277
Publikováno v:
Toxicology and Applied Pharmacology. 135:254-257
Chronic administration of reserpine is associated with the development of pheochromocytomas in rats. Short-term administration of reserpine to rats has been shown to stimulate chromaffin cell proliferation, leading to the hypothesis that reserpine ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913dabf28114ce400dc28d833e60731f
https://doi.org/10.1006/taap.1995.1231
https://doi.org/10.1006/taap.1995.1231
Autor:
Gary M. Williams, R.M. McClain, J. Whysner, F. Montandon, J C Downing, Lynne Verna, R.E. Steward
Publikováno v:
Toxicology and applied pharmacology. 148(1)
Phenobarbital (PB), polychlorinated biphenyls (PCBs), and chlordane (CLD) increase liver tumor incidences in rodents, and all are tumor promoters. Most indirect tests for DNA reactivity, including mutagenicity and chromosomal damage, have been negati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a551a447463da7e4f17484e133db3c7
https://pubmed.ncbi.nlm.nih.gov/9465259
https://pubmed.ncbi.nlm.nih.gov/9465259
Autor:
R. Michael McClain, Arthur S. Tischler, J C Downing, James F. Powers, Jeffrey Ziar, Jocelyn C. Riseberg, Mehzad Shahsavari
Publikováno v:
Toxicology and applied pharmacology. 140(1)
Chronic consumption by rats of diets rich in sugars or sugar alcohols leads to an increased incidence of pheochromocytomas. This relationship is hypothesized to be based on altered Ca 2+ homeostasis due to increased intestinal Ca 2+ absorption. Other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::addb665a9565874a6ca48b021494178e
https://pubmed.ncbi.nlm.nih.gov/8806877
https://pubmed.ncbi.nlm.nih.gov/8806877
Autor:
Margaret L. Harbison, J C Downing, Jay I. Goodman, Jennifer L. Counts, Juan I. Sarmiento, R. Michael McClain
Publikováno v:
Carcinogenesis. 17(6)
Our laboratory is testing the hypothesis that hypomethylation of DNA [a decreased content of 5-methylcytosine (5MeC) compared with cytosine] facilitates aberrant oncogene expression involved in tumorigenesis, using a model system of mouse strains wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01aa99291b1611e876077e46513563bf
https://pubmed.ncbi.nlm.nih.gov/8681439
https://pubmed.ncbi.nlm.nih.gov/8681439
Publikováno v:
Toxicology and Applied Pharmacology. 99:216-228
The effect of phenobarbital on thyroid function and the metabolism and biliary excretion of thyroxine in rats was determined. Phenobarbital, administered for 2 weeks at a dose of 100 mg/kg/day, resulted in an increase in hepatic and thyroid gland wei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a9dbf0d7b1b6953f7ffd1c030bb8ca9
https://doi.org/10.1016/0041-008x(89)90004-5
https://doi.org/10.1016/0041-008x(89)90004-5
Publikováno v:
Fundamental and Applied Toxicology. 12:386-396
The reproductive toxicology of metronidazole was studied in rats. Male Charles River Crl:CD(SD)BR rats (10/group) were treated with metronidazole as a dietary admixture at doses of 0 (control), 25, 100, and 400 mg/kg/day for 8 weeks. The reversibilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b080c358b76cf10605a97b54146df0b
https://doi.org/10.1016/0272-0590(89)90014-6
https://doi.org/10.1016/0272-0590(89)90014-6
Autor:
J C, Downing
Publikováno v:
Modern veterinary practice. 55(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::de0b14dc515cb8bc3131d268003ee669
https://pubmed.ncbi.nlm.nih.gov/4820442
https://pubmed.ncbi.nlm.nih.gov/4820442