Výsledky vyhledávání - "J C Bulinski"

Overexpression of MAP4 inhibits organelle motility and trafficking in vivo

Autor: J C, Bulinski, T E, McGraw, D, Gruber, H L, Nguyen, M P, Sheetz

Publikováno v: Journal of Cell Science. 110:3055-3064

We previously prepared cell lines that inducibly overexpress MAP4, a microtubule (MT)-associated protein widely expressed in non-neuronal cells. Overexpression of either the full-length MAP4 molecule or its MT-binding domain, MTB, stabilized MTs and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3809f462420302fb5e6b6fd030d62065
https://doi.org/10.1242/jcs.110.24.3055

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Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics

Autor: Shin-ichi Hisanaga, J. C. Bulinski, H. Aizawa, Kayoko Ookata, Takeo Kishimoto, Takehiko Itoh, H. Murofushi, Kazunori Tachibana, Eiichi Okumura, Hirokazu Hotani

Publikováno v: The Journal of Cell Biology

We previously demonstrated (Ookata et al., 1992, 1993) that the p34cdc2/cyclin B complex associates with microtubules in the mitotic spindle and premeiotic aster in starfish oocytes, and that microtubule-associated proteins (MAPs) might be responsibl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b5e6456dd2688d896a6dc22a223022
https://doi.org/10.1083/jcb.128.5.849

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Accompanying protein alterations in malignant cells with a microtubule-polymerizing drug-resistance phenotype and a primary resistance mechanism

Autor: M S, Poruchynsky, P, Giannakakou, Y, Ward, J C, Bulinski, W G, Telford, R W, Robey, T, Fojo

Publikováno v: Biochemical pharmacology. 62(11)

Microtubules (MTs) are cytoskeletal components whose structural integrity is mandatory for the execution of many basic cell functions. Utilizing parental and drug-resistant ovarian carcinoma cell lines that have acquired point mutations in beta-tubul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::132cef98dcd8e0c5ef30f837748da9ed
https://pubmed.ncbi.nlm.nih.gov/11728383

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Mitogen-activated protein kinase/extracellular signal-regulated kinase 2 regulates cytoskeletal organization and chemotaxis via catalytic and microtubule-specific interactions

Autor: Alfred A. Reszka, J C Bulinski, E G Krebs, Edmond H. Fischer

Publikováno v: Molecular biology of the cell. 8(7)

The extracellular signal-regulated kinases (ERKs) 1 and 2 are mitogen-activated protein kinases that act as key components in a signaling cascade linking growth factor receptors to the cytoskeleton and the nucleus. ERK2 mutants have been used to alte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5264d10129dc86f0e019ee9f5519d369
https://pubmed.ncbi.nlm.nih.gov/9243503

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Preparation and functional assay of pure populations of tyrosinated and detyrosinated tubulin

Autor: S J, Chapin, J C, Bulinski

Publikováno v: Methods in enzymology. 196

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::908cf3e3162371632a2437dd6f84ab20
https://pubmed.ncbi.nlm.nih.gov/1674580

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The MAP4 projection domain inhibits microtubules from forming bundles

Autor: Tomohiko J. Itoh, J. C. Bulinski, H. Toyota, Junko Iida, Shin-ichi Hisanaga, Hirokazu Hotani

Publikováno v: Seibutsu Butsuri. 39:S44

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e44af4fbeb708ba28d621f5b6dc5714
https://doi.org/10.2142/biophys.39.s44_4

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Posttranslational modification and microtubule stability

Autor: Eric Schulze, J C Bulinski, D J Asai, Marc W. Kirschner

Publikováno v: The Journal of Cell Biology

We have probed the relationship between tubulin posttranslational modification and microtubule stability, using a variation of the antibody-blocking technique. In human retinoblastoma cells we find that acetylated and detyrosinated microtubules repre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee0e9af76682f983521b4faa07b8051
https://doi.org/10.1083/jcb.105.5.2167

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Microtubule arrays in differentiated cells contain elevated levels of a post-translationally modified form of tubulin

Autor: G G, Gundersen, J C, Bulinski

Publikováno v: European journal of cell biology. 42(2)

Tyrosinated (Tyr) and detyrosinated (Glu) alpha-tubulins are post-translationally modified species that differ by a single amino acid at their respective C-termini. We have examined the distribution of these two species by immunofluorescence in proli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::beb237d659de5be058df737ba45e34fb
https://pubmed.ncbi.nlm.nih.gov/3545837

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Preparation of antibodies reactive with specific regions of cytoskeletal proteins

Autor: J C, Bulinski, G G, Gundersen

Publikováno v: Methods in enzymology. 134

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d75af7d64008a4b63e690cdb6b77968d
https://pubmed.ncbi.nlm.nih.gov/2434827

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Microtubule-associated proteins from cultured HeLa cells. Analysis of molecular properties and effects on microtubule polymerization

Autor: J C, Bulinski, G G, Borisy

Publikováno v: The Journal of biological chemistry. 255(23)

We have attempted a biochemical characterization of the microtubule-associated proteins (MAPs) of cultured HeLa cells. The HeLa MAPs consist of a group of three polypeptides of 200,000 to 220,000 molecular weight (the 210K MAP) and a protein of 125,0

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b606349dd9572ab5c646d147e3d22bc6
https://pubmed.ncbi.nlm.nih.gov/7440558

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