Výsledky vyhledávání - "J C, Schimenti"

High-frequency germ line gene conversion in transgenic mice

Autor: J C Schimenti, M Bumbulis, J R Murti

Publikováno v: Molecular and Cellular Biology. 12:2545-2552

Gene conversion is the nonreciprocal transfer of genetic information between two related genes or DNA sequences. It can influence the evolution of gene families, having the capacity to generate both diversity and homogeneity. The potential evolutiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11207573fcdbe01b9a6a3758abe531b6
https://doi.org/10.1128/mcb.12.6.2545

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H chain C domains influence the strength of binding of IgG for streptococcal group A carbohydrate

Autor: L J Cooper, J C Schimenti, D D Glass, N S Greenspan

Publikováno v: The Journal of Immunology. 146:2659-2663

We have produced a panel of murine anti-streptococcal mAbs, expressing identical V domains and different H chain C domains, corresponding to the IgG3, IgG1, and IgG2b subclasses. We have used these mAb to evaluate the role of IgG subclass-specific C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b2011fd473271e07d41f371d7b5ec9dd
https://doi.org/10.4049/jimmunol.146.8.2659

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Homologous recombinational repair proteins in mouse meiosis

Autor: L A Bannister, J C Schimenti

Publikováno v: Cytogenetic and genome research. 107(3-4)

Eukaryotic meiotic recombination requires numerous biochemical processes, including break initiation, end resection, strand invasion and heteroduplex formation, and, finally, crossover resolution. In this review, we discuss primarily those proteins i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654de959ae937401132bac989bd2deda
https://pubmed.ncbi.nlm.nih.gov/15467364

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Midgestation lethality in mice deficient for the RecA-related gene, Rad51d/Rad51l3

Autor: D L, Pittman, J C, Schimenti

Publikováno v: Genesis (New York, N.Y. : 2000). 26(3)

Homologous recombination (HR) occurs in all organisms, and is important for repair of DNA damage, chromosome segregation during meiosis, and genetic diversification. Genes critical for recombinational DNA repair and meiotic recombination include memb

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https://pubmed.ncbi.nlm.nih.gov/10705376

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Recombination in the mammalian germ line

Autor: D L, Pittman, J C, Schimenti

Publikováno v: Current topics in developmental biology. 37

Elucidation of meiotic recombination mechanisms in mammals faces many obstacles. Much of our understanding has been built upon studies in the fungi, which have served to guide experimental design in mammalian cells and mice. A clearer picture is now

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https://pubmed.ncbi.nlm.nih.gov/9352182

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Function of untranslated regions in the mouse spermatogenesis-specific gene Tcp10 evaluated in transgenic mice

Autor: U K Ewulonu, J C Schimenti

Publikováno v: DNA and cell biology. 16(5)

The mouse Tcp10 genes are transcribed exclusively in male germ cells and display multiple 5′ and 3′ untranslated variations generated by alternative splicing and polyadenylation signal usage. To investigate the possible role of untranslated seque

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https://pubmed.ncbi.nlm.nih.gov/9174169

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Promoter mapping of the mouse Tcp-10bt gene in transgenic mice identifies essential male germ cell regulatory sequences

Autor: U K, Ewulonu, L, Snyder, L M, Silver, J C, Schimenti

Publikováno v: Molecular reproduction and development. 43(3)

Transgenic mice were generated to localize essential promoter elements in the mouse testis-expressed Tcp-10 genes. These genes are expressed exclusively in male germ cells, and exhibit a diffuse range of transcriptional start sites, possibly due to t

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https://pubmed.ncbi.nlm.nih.gov/8868241

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Gene conversion between unlinked sequences in the germline of mice

Autor: M Bumbulis, J R Murti, J C Schimenti

Publikováno v: Genetics. 137(3)

Gene conversion between homologous sequences on non-homologous chromosomes (ectopic gene conversion) is remarkably frequent in fungi. It is thought to be a consequence of genome-wide homology scanning required to form synapses between homologous chro

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https://pubmed.ncbi.nlm.nih.gov/8088528

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