Zobrazeno 1 - 3
of 3
pro vyhledávání: '"J C, Rodarte"'
Autor:
S, Sarshar, C, Zhang, E J, Moran, S, Krane, J C, Rodarte, K D, Benbatoul, R, Dixon, A M, Mjalli
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(23)
N-4,5-Di-(4-dialkylamino)phenyl imidazoles (A) are potent modulators of P-glycoprotein mediated multidrug resistance. This manuscript describes the discovery and lead optimization of this novel class of inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d2dbee580c33c15e7cd854f8698adee
https://pubmed.ncbi.nlm.nih.gov/11128632
https://pubmed.ncbi.nlm.nih.gov/11128632
Autor:
C, Zhang, S, Sarshar, E J, Moran, S, Krane, J C, Rodarte, K D, Benbatoul, R, Dixon, A M, Mjalli
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(23)
Solution-phase combinatorial chemistry was applied to the optimization and development of clinical candidate OC144-093 (22), a novel and nontoxic modulator of P-glycoprotein mediated multidrug resistance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::99ec1a49163991fc5d62d3a7e98148a0
https://pubmed.ncbi.nlm.nih.gov/11128633
https://pubmed.ncbi.nlm.nih.gov/11128633
Autor:
M J, Newman, J C, Rodarte, K D, Benbatoul, S J, Romano, C, Zhang, S, Krane, E J, Moran, R T, Uyeda, R, Dixon, E S, Guns, L D, Mayer
Publikováno v:
Cancer research. 60(11)
OC144-093 is a novel substituted diarylimidazole (Mr 495) generated using the OntoBLOCK system, a solid-phase combinatorial chemistry technology, in combination with high-throughput cell-based screening. OC144-093 reversed multidrug resistance (MDR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9f1935ae208e878ecb9aef1e9fec3456
https://pubmed.ncbi.nlm.nih.gov/10850444
https://pubmed.ncbi.nlm.nih.gov/10850444