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Chymase-directed serine protease inhibitor that reacts with a single 30-kDa granzyme and blocks NK-mediated cytotoxicity

Autor: S L Woodard, D S Jackson, A S Abuelyaman, J C Powers, U Winkler, D Hudig

Publikováno v: The Journal of Immunology. 153:5016-5025

Cytotoxic NK and T lymphocytes kill virally infected cells within minutes without causing damage to themselves or bystander cells. One mechanism of killing involves exocytosis of granules containing serine proteases and perforin. Serine protease inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0198baeb715fa88c759fef8bc9f13f1
https://doi.org/10.4049/jimmunol.153.11.5016

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Purification and cloning of a novel serine protease, RNK-Met-1, from the granules of a rat natural killer cell leukemia

Autor: T Wiltrout, J C Powers, Mark J. Smyth, C M Kam, T J Sayers, R Sowder, H A Young, Joseph A. Trapani, L E Henderson, K S Ottaway

Publikováno v: Scopus-Elsevier

We have purified a 30-kDa serine protease (designated RNK-Met-1) from the granules of the rat large granular lymphocyte leukemia cell line (RNK-16) that hydrolytically cleaves model peptide substrates after methionine, leucine, and norleucine (Met-as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19132ec0c09ac8ff75a0f47d0e63304a
https://doi.org/10.1016/s0021-9258(18)35783-1

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Substituted isocoumarins as inhibitors of complement serine proteases

Autor: C M Kam, T J Oglesby, M K Pangburn, J E Volanakis, J C Powers

Publikováno v: The Journal of Immunology. 149:163-168

Inhibition of complement proteins D, B, C2, C1s, C1r, I, and the catalytic fragments Bb and C2a by substituted isocoumarins was investigated. 3,4-Dichloroisocoumarin, a general serine protease inhibitor, inhibited factor D, C1r, and C1s moderately wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fa86fe8932f069fc8efa23db9ab0574
https://doi.org/10.4049/jimmunol.149.1.163

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Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions

Autor: Arnold H. Greenberg, Lianfa Shi, J. C. Powers, R. Aebersold, Chih-Min Kam

Publikováno v: The Journal of Experimental Medicine

We recently reported the purification of a lymphocyte granule protein called "fragmentin," which was identified as a serine protease with the ability to induce oligonucleosomal DNA fragmentation and apoptosis (Shi, L., R. P. Kraut, R. Aebersold, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ebb96686c57ae444723a86d66ff2ef
http://europepmc.org/articles/PMC2119451

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Cutaneous protease activity in the mouse ear vesicant model

Autor: J C, Powers, C M, Kam, K M, Ricketts, R P, Casillas

Publikováno v: Journal of applied toxicology : JAT. 20

Tissue homogenates from mouse ear skin exposed to sulfur mustard (HD, which is a military designation and probably originated from a World War I slang term 'Hun Stuff') were assayed for serine and cysteine protease activities. Enzyme activity was mea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1bfd706e18533ccbbc3ae5f77ee094d0
https://pubmed.ncbi.nlm.nih.gov/11428632

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Efficacy of novel calpain inhibitors in preventing renal cell death

Autor: J F, Harriman, S, Waters-Williams, D L, Chu, J C, Powers, R G, Schnellmann

Publikováno v: The Journal of pharmacology and experimental therapeutics. 294(3)

Inhibitors of calpains, calcium-activated neutral proteases, protect against cell death produced by anoxia and a variety of toxicants both in vitro and in vivo. The problems with known calpain inhibitors are a lack of specificity, low membrane permea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d7bbb44bf9e69193b5a8c250f4efe719
https://pubmed.ncbi.nlm.nih.gov/10945863

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Electrostatic reversal of serine proteinase substrate specificity

Autor: A, Caputo, J C, Parrish, M N, James, J C, Powers, R C, Bleackley

Publikováno v: Proteins. 35(4)

Mouse granzyme B is a member of the chymotrypsin family of serine proteinases that has an unusual preference for cleavage of substrates following aspartate residues. We show here that granzyme B can be redesigned by a single amino acid substitution i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::134e9a352481dbcbce096d276c6469c5
https://pubmed.ncbi.nlm.nih.gov/10382669

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Lower extremity purpura associated with new-onset autoimmune hepatitis: an unusual presentation

Autor: J C, Powers, J C, Hill, W J, Grabski

Publikováno v: Cutis. 62(2)

Autoimmune hepatitis is a chronic necroinflammatory disorder of unknown cause. The morbidity and mortality of this potentially lethal disorder can be minimized by timely diagnosis and treatment. Patients can present with a wide variety of clinical an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dcac8a4b8124871209c48ca2b5fd4675
https://pubmed.ncbi.nlm.nih.gov/9714909

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Purification and characterization of lymphocyte chymase I, a granzyme implicated in perforin-mediated lysis

Autor: S L, Woodard, S A, Fraser, U, Winkler, D S, Jackson, C M, Kam, J C, Powers, D, Hudig

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 160(10)

One mechanism of killing by cytotoxic lymphocytes involves the exocytosis of specialized granules. The released granules contain perforin, which assembles into pores in the membranes of cells targeted for death. Serine proteases termed granzymes are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4e00006e49855c8031f23f4e7d8a0996
https://pubmed.ncbi.nlm.nih.gov/9590247

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