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CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation

Autor: M, Fujimoto, J C, Poe, M, Hasegawa, T F, Tedder

Publikováno v: The Journal of biological chemistry. 276(48)

B lymphocyte antigen receptor (BCR) signals are regulated by CD19, with BCR-induced intracellular calcium ([Ca(2+)](i)) responses enhanced by CD19 co-ligation. In this study, CD19 engagement using a dimeric anti-CD19 antibody induced [Ca(2+)](i) mobi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3936642d34aed9e9911b0977471fe77a
https://pubmed.ncbi.nlm.nih.gov/11584010

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CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux

Autor: J C, Poe, M, Fujimoto, P J, Jansen, A S, Miller, T F, Tedder

Publikováno v: The Journal of biological chemistry. 275(23)

CD22 is a cell surface molecule that regulates signal transduction in B lymphocytes. Tyrosine-phosphorylated CD22 recruits numerous cytoplasmic effector molecules including SHP-1, a potent phosphotyrosine phosphatase that down-regulates B cell antige

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::35661ed05a6c5c0ad2826ec4706bbef8
https://pubmed.ncbi.nlm.nih.gov/10748054

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CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation

Autor: M, Fujimoto, J C, Poe, P J, Jansen, S, Sato, T F, Tedder

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 162(12)

Ligation of the B cell Ag receptor (BCR) induces cellular activation by stimulating Src-family protein tyrosine kinases (PTKs) to phosphorylate members of the BCR complex. Subsequently, Src-family PTKs, particularly Lyn, are proposed to phosphorylate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::46d4cd781a4e6a11dea83cb883330146
https://pubmed.ncbi.nlm.nih.gov/10358152

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CD40 signaling of monocyte inflammatory cytokine synthesis through an ERK1/2-dependent pathway. A target of interleukin (il)-4 and il-10 anti-inflammatory action

Autor: J, Suttles, D M, Milhorn, R W, Miller, J C, Poe, L M, Wahl, R D, Stout

Publikováno v: The Journal of biological chemistry. 274(9)

Ligation of CD40 on monocytes through its interaction with CD40 ligand (CD154) present on activated T helper cells, results in activation of monocyte inflammatory cytokine synthesis and rescue of monocytes from apoptosis induced through serum depriva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a92eb3ea65a051dcd56805e3a463fba4
https://pubmed.ncbi.nlm.nih.gov/10026206

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IL-4 and IL-10 modulation of CD40-mediated signaling of monocyte IL-1beta synthesis and rescue from apoptosis

Autor: J C, Poe, D H, Wagner, R W, Miller, R D, Stout, J, Suttles

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 159(2)

Previous studies have demonstrated that the interaction of CD40 on monocytes with CD40 ligand, present on activated CD4+ T cells, induces monocyte inflammatory cytokine synthesis and rescues monocytes from apoptosis. These findings suggest a role for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c170c43fc5f677fc3adfb21e0c68c673
https://pubmed.ncbi.nlm.nih.gov/9218603

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