Zobrazeno 1 - 10
of 11
pro vyhledávání: '"J C, Nadal"'
Publikováno v:
JNCI Journal of the National Cancer Institute. 83:437-442
Effects of oral administrations of uridine were investigated in a study of six healthy volunteer control subjects and nine patients with metastatic colorectal cancer. Oral uridine was studied as single-dose administrations at doses escalating from 0.
Autor:
Martin Wagenmann, Chester C. Wood, M. Roecker-Cooper, Robert M. Naclerio, Fuad M. Baroody, J. C. Nadal, R. Jankowski
Publikováno v:
Clinical Experimental Allergy. 24:288-290
We performed a randomized, double-blind, placebo-controlled cross-over study with two different concentrations of ipratropium bromide (Atrovent) nasal spray to evaluate its onset and duration of inhibition. Twenty-four subjects with perennial rhiniti
Autor:
G J, Peters, G, Schwartsmann, J C, Nadal, E J, Laurensse, C J, van Groeningen, W J, van der Vijgh, H M, Pinedo
Publikováno v:
Cancer research. 50(15)
Little is known about the in vivo effects of inhibition of the mitochondrial pyrimidine de novo synthesis enzyme dihydroorotic acid dehydrogenase (DHO-DH). In mice a new inhibitor of DHO-DH, Brequinar sodium (DUP-785, NSC 368390) depleted the plasma
Publikováno v:
Biochemical Pharmacology, 39, 135-144. Elsevier Inc.
Peters, G J, Nadal, J C, Laurensse, E, de Kant, E & Pinedo, H M 1990, ' Retention of in vivo antipyrimidine effects of brequinar sodium (DUP-785;NSC 368390) in murine liver, bone marrow and colon cancer ', Biochemical Pharmacology, vol. 39, pp. 135-144 .
Peters, G J, Nadal, J C, Laurensse, E, de Kant, E & Pinedo, H M 1990, ' Retention of in vivo antipyrimidine effects of brequinar sodium (DUP-785;NSC 368390) in murine liver, bone marrow and colon cancer ', Biochemical Pharmacology, vol. 39, pp. 135-144 .
Brequinar sodium (DUP-785) is a potent inhibitor of the pyrimidine de novo enzyme, dihydroorotic acid dehydrogenase (DHO-DH). In order to determine whether in vitro data could be extrapolated to the in vivo situation we investigated antipyrimidine ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bcdd5cb9fc347c9def22569a2315e54
https://research.vumc.nl/en/publications/084b6e8e-1e7b-4cf9-8901-936093972acf
https://research.vumc.nl/en/publications/084b6e8e-1e7b-4cf9-8901-936093972acf
Autor:
A. Leyva, E.J. Laurensse, G.J. Peters, J. van Dijk, H.M. Pinedo, C.J. van Groeningen, J. C. Nadal, Jan Lankelma
Publikováno v:
British Journal of Cancer
The effect of delayed uridine administration on the in vitro growth inhibitory effects of 5-fluorouracil (5FU) and on the in vivo antitumour activity and toxicity was studied. In vitro growth inhibition of the human intestinal cell lines WiDr and Int
Publikováno v:
In vivo (Athens, Greece). 1(2)
Mice bearing the murine colon carcinomas Colon 38 or Colon 26 were treated with 5-fluorouracil (5 FU) (60 or 100 mg/kg, respectively) weekly for 4 weeks at 08.30 hr or at 18.30 hr. The antitumor effect of treatment at 08.30 hr was significantly bette
Publikováno v:
Advances in experimental medicine and biology.
Publikováno v:
Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 42(6)
In vitro results have clearly demonstrated that leucovorin (LV) can enhance the growth inhibitory effects of 5-fluorouracil (5FU) but in vivo potentiation of the antitumor effect of 5FU by LV has not yet been defined in animal models. The antitumor e
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781468456783
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ca1d9cd9fadb5140ca10cb9319e5750
https://doi.org/10.1007/978-1-4684-5676-9_55
https://doi.org/10.1007/978-1-4684-5676-9_55
Publikováno v:
Investigational new drugs. 7(2-3)
The effect of leucovorin (LV) given in various doses and schedules on the in vivo antitumor activity and toxicity of 5-fluorouracil (5FU) was studied in two murine colon cancer lines, i.e., Colon 26 (relatively resistant to 5FU) and Colon 38 (5FU sen