Zobrazeno 1 - 10
of 36
pro vyhledávání: '"J C, Meijers"'
Autor:
A J, Vlot, S J, Koppelman, J C, Meijers, C, Dama, H M, van den Berg, B N, Bouma, J J, Sixma, G M, Willems
Publikováno v:
Blood. 87:1809-1816
The binding of factor VIII to von Willebrand factor (vWF) is essential for the protection of factor VIII against proteolytic degradation in plasma. We have characterized the binding kinetics of human factor VIII with vWF using a centrifugation bindin
Publikováno v:
Blood. 86:3035-3042
Recently, an alternative pathway for factor XI activation has been described in which factor XI is activated by thrombin. Patients with a factor XI deficiency bleed mostly from tissues with high local fibrinolytic activity. Therefore, the role of thr
Publikováno v:
Blood. 79:1435-1440
Human factor XI (FXI) is a blood coagulation factor participating in the early phase of the intrinsic pathway of blood coagulation. It circulates in blood as a glycoprotein composed of two identical chains held together by a single disulfide bond bet
Publikováno v:
Thrombosis and haemostasis. 86(4)
Thrombin Activatable Fibrinolysis Inhibitor (TAFI) is a carboxy-peptidase B-like proenzyme that after activation by thrombin down regulates fibrinolysis. Thrombomodulin (TM) stimulates the activation of both TAFI and protein C whereas activated prote
Publikováno v:
Thrombosis and haemostasis. 86(4)
TAFI (thrombin activatable fibrinolysis inhibitor) down regulates fibrinolysis after activation by relatively high concentrations of thrombin generated during coagulation via thrombin mediated factor XI activation and subsequent activation of the int
Publikováno v:
Thrombosis and haemostasis. 86(4)
Thrombin activatable fibrinolysis inhibitor (TAFI) is a carboxy-peptidase B-like proenzyme that after activation by thrombin downregulates fibrinolysis. Thrombomodulin stimulates the activation of both TAFI and protein C whereas activated protein C i
Autor:
M J, Simmelink, D A, Horbach, R H, Derksen, J C, Meijers, E M, Bevers, G M, Willems, P G, De Groot
Publikováno v:
British journal of haematology. 113(3)
We investigated the mechanism by which anti-prothrombin antibodies cause lupus anticoagulant (LAC) activity. Addition of affinity-purified anti-prothrombin antibodies from LAC-positive plasma samples (alpha-FII-LAC+) to normal plasma induced LAC acti
Autor:
R F, Franco, M G, Fagundes, J C, Meijers, P H, Reitsma, D, Lourenço, V, Morelli, F H, Maffei, I C, Ferrari, C E, Piccinato, W A, Silva, M A, Zago
Publikováno v:
Haematologica. 86(5)
Thrombin activatable fibrinolysis inhibitor (TAFI) plays an important role in hemostasis, functioning as a potent fibrinolysis inhibitor. TAFI gene variations may contribute to plasma TAFI levels and thrombotic risk.We sequenced a 2083-bp region of t
Publikováno v:
Thrombosis and haemostasis. 85(5)
Activated protein C (APC) is an important inactivator of coagulation factors Va and VIIIa. In the inactivation of factors Va and VIIIa, protein S serves as a cofactor to APC. Protein S can bind to C4b-binding protein (C4BP), and thereby loses its cof
Autor:
E C, van Gorp, M C, Minnema, C, Suharti, A T, Mairuhu, D P, Brandjes, H, ten Cate, C E, Hack, J C, Meijers
Publikováno v:
British journal of haematology. 113(1)
A prospective cohort study was performed in 50 patients with dengue haemorrhagic fever (DHF) to determine the potential role of the contact activation system and factor XI activation (intrinsic pathway) in the coagulation disorders in DHF. To establi