Zobrazeno 1 - 10
of 16
pro vyhledávání: '"J C, Knutson"'
Autor:
C. W. Bishop, J. C. Knutson, A. U. Tan, J. W. Coburn, B. S. Levine, R. B. Mazess, D. M. Kyllo
Publikováno v:
Nephrology Dialysis Transplantation. 11:153-157
Calcitriol is effective in suppressing PTH levels in haemodialysis patients with hyperparathyroidism but has a low therapeutic index. There is a search for other vitamin D sterols that suppress PTH but cause less hypercalcaemia. We review evidence th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e6a4f085f87262c2efa815341463b99
https://doi.org/10.1093/ndt/11.supp3.153
https://doi.org/10.1093/ndt/11.supp3.153
Publikováno v:
Endocrinology. 136:4749-4753
The vitamin D analog 1 alpha-hydroxyvitamin D2 (1 alpha-OHD2) is under development for the treatment of secondary hyperparathyroidism and metabolic bone disease. This analog is metabolized in vivo to the natural active dihydroxylated metabolite of vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3405d4a78669b37445004dc728d13053
https://doi.org/10.1210/endo.136.11.7588202
https://doi.org/10.1210/endo.136.11.7588202
Autor:
J C Knutson, R M Moriarty, C W Bishop, L W LeVan, Stephen Strugnell, R Gilardi, Glenville Jones, Valarie Byford, Hugh L.J. Makin
Publikováno v:
Biochemical Journal. 310:233-241
A major metabolite of the vitamin D analogue 1 alpha-hydroxyvitamin D2 in human liver cells in culture has been identified as 1 alpha,24(S)-dihydroxyvitamin D2 [1 alpha,24(S)-(OH)2D2]. 1 alpha-Hydroxyvitamin D3 incubated with the same cells gives ris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d1a1c507633ef1bff1156a416969255
https://doi.org/10.1042/bj3100233
https://doi.org/10.1042/bj3100233
Autor:
S. A. Strugnell, Omar Akhouayri, J. C. Knutson, Alice Arabian, René St-Arnaud, Vionnie W.C. Yu
Publikováno v:
Journal of endocrinological investigation. 31(8)
Background: Vitamin D compounds are effective in managing elevated PTH levels in secondary hyperparathyroidism (SHPT) of renal failure. However, undesired increases in serum calcium and phosphorus associated with compounds such as calcitriol [1,25(OH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f6e30a8806072910a253c0bd917caad
https://pubmed.ncbi.nlm.nih.gov/18852532
https://pubmed.ncbi.nlm.nih.gov/18852532
Publikováno v:
Anticancer research. 25(6B)
Active vitamin D compounds have been developed that maintain antiproliferative properties with low calcemic activity. BCI-210, a novel vitamin D pro-drug developed in our laboratory, is activated through side chain hydroxylation and possesses lower c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d8ceaea8312005a10278ff0871c0cb80
https://pubmed.ncbi.nlm.nih.gov/16309237
https://pubmed.ncbi.nlm.nih.gov/16309237
Publikováno v:
Anticancer research. 25(3B)
Bisphosphonates have proven to be effective in the management of multiple myeloma and bone metastases secondary to breast and prostate carcinoma. Vitamin D compounds are important modulators of cellular proliferation and differentiation. 1,24(S)-dihy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c64a59e9c35c9a6a06e31092e677ab26
https://pubmed.ncbi.nlm.nih.gov/16158925
https://pubmed.ncbi.nlm.nih.gov/16158925
Publikováno v:
Anticancer research. 24(5A)
Vitamin D compounds are important modulators of cellular proliferation and differentiation, with potential utility as anticancer drugs. 1,24(S)-Dihydroxyvitamin D2 [1,24(OH)2D2] is a naturally occurring active vitamin D compound with low calcemic act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc2e39882f4613dec689c9d1f2b1358a
https://pubmed.ncbi.nlm.nih.gov/15517895
https://pubmed.ncbi.nlm.nih.gov/15517895
Publikováno v:
Anticancer research. 18(3A)
The physiologically active metabolite of the vitamin D seco-steroid hormone, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), is a major regulator of mineral homeostasis. Recent evidence also suggests its role in regulating proliferation and differentiation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::09c2940946fb21e087856c7a96fb31c1
https://pubmed.ncbi.nlm.nih.gov/9673403
https://pubmed.ncbi.nlm.nih.gov/9673403
Autor:
E B, Mawer, G, Jones, M, Davies, P E, Still, V, Byford, N J, Schroeder, H L, Makin, C W, Bishop, J C, Knutson
Publikováno v:
The Journal of clinical endocrinology and metabolism. 83(6)
We have produced evidence for a new metabolic pathway for vitamin D2 in humans involving the production of 24-hydroxyvitamin D2 (24OHD2) and 1,24-dihydroxyvitamin D2 [1,24-(OH)2D2]. These metabolites were produced after either a single large dose (10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7863db1a12c57afa15c14fca7e6f72e8
https://pubmed.ncbi.nlm.nih.gov/9626155
https://pubmed.ncbi.nlm.nih.gov/9626155
Publikováno v:
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 11
Calcitriol is effective in suppressing PTH levels in haemodialysis patients with hyperparathyroidism but has a low therapeutic index. There is a search for other vitamin D sterols that suppress PTH but cause less hypercalcaemia. We review evidence th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c3f1822af7aba8cbb29988acfeaa2198
https://pubmed.ncbi.nlm.nih.gov/8840332
https://pubmed.ncbi.nlm.nih.gov/8840332