Zobrazeno 1 - 10
of 16
pro vyhledávání: '"J C, Hancox"'
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 378
The congenital short QT syndrome (SQTS) is a rare condition characterized by abbreviated rate-corrected QT (QTc) intervals on the electrocardiogram and by increased susceptibility to both atrial and ventricular arrhythmias and sudden death. Although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::140b4955cb955f591c91734876a696f2
https://doi.org/10.1098/rstb.2022.0165
https://doi.org/10.1098/rstb.2022.0165
Publikováno v:
Heart. 84:14-24
The past two decades have witnessed a rapid growth in understanding of the cellular and molecular basis of both normal and pathological electrophysiology. Elucidation of cardiac ion channel structure and function has contributed to many of these adva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8a483ca9a9fbeb1f2d86cb613884cc
https://doi.org/10.1136/heart.84.1.14
https://doi.org/10.1136/heart.84.1.14
Autor:
J. S. Mitcheson, J. C. Hancox
Publikováno v:
Pfl�gers Archiv European Journal of Physiology. 438:843-850
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1127fe46c0628ad5cdadbea6e5785028
https://doi.org/10.1007/s004240051114
https://doi.org/10.1007/s004240051114
Autor:
Frank Christopher Howarth, J V Jones, J Issberner, Stephen J. Evans, Ion A. Hobai, G R Dalton, J S Mitcheson, J C Hancox, Allan J. Levi, J A Bates
Publikováno v:
Journal of Cardiovascular Electrophysiology. 8:700-721
A number of clinical cardiac disorders may be associated with a rise of the intracellular Na concentration (Na(i)) in heart muscle. A clear example is digitalis toxicity, in which excessive inhibition of the Na/K pump causes the Na(i) concentration t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6cab7a988352e981f79fd22d43cc21
https://doi.org/10.1111/j.1540-8167.1997.tb01834.x
https://doi.org/10.1111/j.1540-8167.1997.tb01834.x
Autor:
A J, Alexandrou, J T, Milnes, S Z, Sun, B, Fermini, S C, Kim, S, Jenkinson, D J, Leishman, H J, Witchel, J C, Hancox, J L, Leaney
Publikováno v:
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 65(4)
Diverse non-cardiac drugs adversely influence cardiac electrophysiology by inhibiting repolarising K(+) currents mediated by channels encoded by the human ether-a-go-go-related gene (hERG). In this study, pharmacological blockade of hERG K(+) channel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5a550b58d8f7fdcd5786b04cd3d908da
https://pubmed.ncbi.nlm.nih.gov/25179083
https://pubmed.ncbi.nlm.nih.gov/25179083
Autor:
J C, Hancox
Rosiglitazone is a widely used oral hypoglycaemic agent, which improves insulin resistance in type 2 diabetes. Chronic rosiglitazone treatment is associated with a number of adverse cardiac events. The present study was designed to characterize the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b1f68ea7e24e74779df15ee14aff1cea
https://europepmc.org/articles/PMC3101612/
https://europepmc.org/articles/PMC3101612/
Autor:
R. M. Pitman, J. C. Hancox
Publikováno v:
Journal of Experimental Biology. 176:307-310
Cyclical patterns of behaviour such as respiration and locomotion are generated by groups of neurones whose output depends not only upon their synaptic interconnections but also on the intrinsic membrane properties of individual cells. For example, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a39d5f387ba5887636b05cd543471404
https://doi.org/10.1242/jeb.176.1.307
https://doi.org/10.1242/jeb.176.1.307
Publikováno v:
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 61(6)
KCNQ1 is responsible for the pore-forming subunit of channels that mediate the cardiac 'IKs' potassium channel current. The S140G KCNQ1 gain-of-function mutation is responsible for a form of heritable atrial fibrillation. Here the action potential (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::97e26c3e8f98666161505257b06647eb
https://pubmed.ncbi.nlm.nih.gov/21224508
https://pubmed.ncbi.nlm.nih.gov/21224508
Publikováno v:
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 61(2)
The slow delayed rectifier potassium current, 'I(Ks)', contributes to repolarisation of cardiac ventricular action potentials and thereby to the duration of the QT interval of the electrocardiogram. Mutations to I(Ks) channel subunits occur in clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d1661f58c57c48fc98c84fb6ccdcef9
https://pubmed.ncbi.nlm.nih.gov/20436212
https://pubmed.ncbi.nlm.nih.gov/20436212
Publikováno v:
British journal of pharmacology. 155(6)
The short QT syndrome (SQTS) is associated with cardiac arrhythmias and sudden death. The SQT1 form of SQTS results from an inactivation-attenuated, gain-of-function mutation (N588K) to the human ether-à-go-go-related gene (hERG) potassium channel.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a0e002566a7d1584f9433764b4baef8
https://pubmed.ncbi.nlm.nih.gov/18724381
https://pubmed.ncbi.nlm.nih.gov/18724381