Zobrazeno 1 - 10
of 27
pro vyhledávání: '"J C, Gorski"'
Autor:
J C Gorski, Zeruesenay Desta, Mehul Desai, David A. Flockhart, Million Arefayene, Lang Li, Jose E. Tanus-Santos, Yunlong Liu
Publikováno v:
The Pharmacogenomics Journal. 3:105-113
We studied the pharmacokinetics and QT interval pharmacodynamics of a single 10 mg dose of oral haloperidol in a randomized, double-blind, placebo-controlled, crossover trial of healthy poor (PMs) and extensive (EMs) metabolizers of CYP2D6. There was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616898f21880cd1d242b2bdcdd42775e
https://doi.org/10.1038/sj.tpj.6500160
https://doi.org/10.1038/sj.tpj.6500160
Publikováno v:
British Journal of Clinical Pharmacology. 55:77-85
Aims Cytochrome P450 2E1 (CYP2E1) is thought to activate a number of protoxins, and has been implicated in the development of liver disease. Increased hepatic expression of CYP2E1 occurs in rat models of diabetes but it is unclear whether human diabe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7666c36af04ed115cdf9ac7c42b924af
https://doi.org/10.1046/j.1365-2125.2003.01731.x
https://doi.org/10.1046/j.1365-2125.2003.01731.x
Publikováno v:
Xenobiotica. 29:931-944
1. To aid in the prediction of drug interactions with alprazolam, the human CYP involved in the 1'- and 4-hydroxylation of alprazolam were characterized using human liver microsomes, expressed enzymes and selective chemical inhibitors. 2. The formati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec597d5d5dc87858405931b6e32e3d6
https://doi.org/10.1080/004982599238173
https://doi.org/10.1080/004982599238173
Publikováno v:
Biochemical Pharmacology. 48:173-182
In an effort to identify the human cytochromes P450 involved in the N-demethylation of dextromethorphan, the kinetics of 3-methoxymorphinan formation were studied in microsomal enzyme systems. Under initial rate conditions, 3-methoxymorphinan formati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaaab62ff7e251f8d8baa8c57fed6e63
https://doi.org/10.1016/0006-2952(94)90237-2
https://doi.org/10.1016/0006-2952(94)90237-2
Publikováno v:
Biochemical Pharmacology. 47:1643-1653
The capabilities of cytochrome P4503A4 (CYP3A4), CYP3A5, and fetal hepatic microsomes containing CYP3A7 to metabolize midazolam were investigated using human hepatic microsomes and purified CYP3A4 and CYP3A5. Under initial rate conditions and high su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed5bdaad6dd10e2e54369bde074214d6
https://doi.org/10.1016/0006-2952(94)90543-6
https://doi.org/10.1016/0006-2952(94)90543-6
Autor:
Howard E. Greenberg, E. T. Nguyen, Joseph D. Ma, L. S. Lee, Shirley M. Tsunoda, Scott R. Penzak, J. C. Gorski
Publikováno v:
International journal of clinical pharmacology and therapeutics. 48(12)
UNLABELLED A previous study reported a 2- and 3-timepoint limited sampling strategy (LSS) model accurately predicted oral midazolam area under the concentration time curve (AUC), and thus cytochrome P450 (CYP) 3A activity. OBJECTIVE This study evalua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9a089906a175aad7d912fc9403b2c6
https://pubmed.ncbi.nlm.nih.gov/22541752
https://pubmed.ncbi.nlm.nih.gov/22541752
Publikováno v:
British journal of clinical pharmacology. 55(1)
Cytochrome P450 2E1 (CYP2E1) is thought to activate a number of protoxins, and has been implicated in the development of liver disease. Increased hepatic expression of CYP2E1 occurs in rat models of diabetes but it is unclear whether human diabetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::132dbada7b48c08c43f0e7ed693a502a
https://pubmed.ncbi.nlm.nih.gov/12534643
https://pubmed.ncbi.nlm.nih.gov/12534643
Publikováno v:
Clinical pharmacology and therapeutics. 70(4)
St John's wort (Hypericum perforatum) is a popular over-the-counter dietary supplement and herbal remedy that has been implicated in drug interactions with substrates of several cytochrome P450 (CYP) isozymes. The effect of St John's wort on CYP acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3c7370dd4b6f317d11c0814d7a0ce311
https://pubmed.ncbi.nlm.nih.gov/11673747
https://pubmed.ncbi.nlm.nih.gov/11673747
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(3)
Diltiazem (DTZ) N-demethylation occurs by cytochrome P-450 (CYP) 3A based on the following observations: 1) a single enzyme Michaelis-Menten model of metabolite formation, 2) high correlations of DTZ N-demethylation activity to other CYP3A activities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::304314da51bff1fdda3aa0a8189ed8e8
https://pubmed.ncbi.nlm.nih.gov/10454485
https://pubmed.ncbi.nlm.nih.gov/10454485
Autor:
M K Reith, Lilly Xu, Donald L. Kaminski, J. C. Gorski, Albert P. Li, A Rasmussen, L K Cheng, Stephen D. Hall
Publikováno v:
Chemico-biological interactions. 107(1-2)
In our laboratory, primary human hepatocytes are being investigated as an in vitro experimental system for the evaluation of pharmacokinetic drug-drug interactions. Our study here represents the first reported study that directly compares the cytochr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5fb6f0f95bfe843233ec935e5e38ae9
https://pubmed.ncbi.nlm.nih.gov/9402947
https://pubmed.ncbi.nlm.nih.gov/9402947