Zobrazeno 1 - 10 of 30 pro vyhledávání: '"J C, Fonseca"'
1
Akademický článek
Pharmacological Activities of Sulfated Fucose-Rich Polysaccharides after Oral Administration: Perspectives for the Development of New Carbohydrate-Based Drugs
Autor: Roberto J. C. Fonseca, Paulo A. S. Mourão
Publikováno v: Marine Drugs, Vol 19, Iss 8, p 425 (2021)
Marine organisms are a source of active biomolecules with immense therapeutic and nutraceutical potential. Sulfated fucose-rich polysaccharides are present in large quantities in these organisms with important pharmacological effects in several biolo
Externí odkaz: https://doaj.org/article/63d3da3f7fbd4b01a9f1da711b6620de
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2
Pharmacological Activities of Sulfated Fucose-Rich Polysaccharides after Oral Administration: Perspectives for the Development of New Carbohydrate-Based Drugs
Autor: Paulo A.S. Mourão, Roberto J. C. Fonseca
Publikováno v: Marine Drugs, Vol 19, Iss 425, p 425 (2021)
Marine Drugs
Marine organisms are a source of active biomolecules with immense therapeutic and nutraceutical potential. Sulfated fucose-rich polysaccharides are present in large quantities in these organisms with important pharmacological effects in several biolo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7158fadbb2bf51a6002863143d4a58f
https://www.mdpi.com/1660-3397/19/8/425
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3
Akademický článek
The protective role of fucosylated chondroitin sulfate, a distinct glycosaminoglycan, in a murine model of streptozotocin-induced diabetic nephropathy.
Autor: Conrado L R Gomes, Cristina L Leão, Carolina Venturotti, André L Barreira, Gabriela Guimarães, Roberto J C Fonseca, Rodrigo S Fortunato, Paulo A S Mourão, Alvimar G Delgado, Christina M Takiya, Maurilo Leite
Publikováno v: PLoS ONE, Vol 9, Iss 9, p e106929 (2014)
Heparanase-1 activation, albuminuria, and a decrease in glomerular heparan sulfate (HS) have been described in diabetic nephropathy (DN). Glycosaminoglycan (GAG)-based drugs have been shown to have renoprotective effects in this setting, although rec
Externí odkaz: https://doaj.org/article/75fca435b0454192a4d93519ff8174b1
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4
A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum
Autor: Gustavo Capatti Cassiano, Cristina P. Vicente, Marcele F. Bastos, Roberto J. C. Fonseca, Letusa Albrecht, Mauro S. G. Pavão, Stefanie Cp Lopes, Fabio T. M. Costa, Claudio C. Werneck, Rodrigo Pm de Almeida, Angélica M Gomes
Publikováno v: Memórias do Instituto Oswaldo Cruz., Vol 114, Iss 0
Memórias do Instituto Oswaldo Cruz, Volume: 114, Article number: e190088, Published: 06 JUN 2019
Memórias do Instituto Oswaldo Cruz
BACKGROUND Despite treatment with effective antimalarial drugs, the mortality rate is still high in severe cases of the disease, highlighting the need to find adjunct therapies that can inhibit the adhesion of Plasmodium falciparum-infected erythrocy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217a1b1353f82d802ba9ec15a2810e88
https://doi.org/10.1590/0074-02760190088
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5
145 Comparison of single to multiple injections of follicle-stimulating hormone before ovum pickup in Holstein heifers: Oocyte recovery and embryo production
Autor: Clarice Garcia Borges Demétrio, M. Oliveira, J. F. Hasler, Ricarda Maria dos Santos, J. C. Fonseca, D. G. B. Demetrio
Publikováno v: Reproduction, Fertility and Development. 33:180
The demand for invitro-produced embryos from heifers with high genetic merit has increased over time. Synchronization and stimulation of follicular growth before ovum pickup (OPU) has been used to improve oocyte quality and, consequently, embryo prod
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::037c4380ebf5f4d3292ed46406be07e4
https://doi.org/10.1071/rdv33n2ab145
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7
Anticoagulant and Antithrombotic Properties of Three Structurally Correlated Sea Urchin Sulfated Glycans and Their Low-Molecular-Weight Derivatives
Autor: Isabela D. Sucupira, Alessandra Lyra Guedes, Ariana A. Vasconcelos, Roberto J. C. Fonseca, Ismael Nilo Lino de Queiroz, Flávia S. Frattani, Vitor H. Pomin
Publikováno v: Marine Drugs, Vol 16, Iss 9, p 304 (2018)
Marine Drugs
Volume 16
Issue 9
The anticoagulant and antithrombotic properties of three structurally correlated sea urchin-derived 3-linked sulfated &alpha
glycans and their low molecular-weight derivatives were screened comparatively through various in vitro and in vivo meth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038e137e1c6265e8392e82711295ae73
http://www.mdpi.com/1660-3397/16/9/304
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8
Improved anticoagulant effect of fucosylated chondroitin sulfate orally administered as gastro-resistant tablets
Autor: Stephan Nicollas Marcin Centena Goulart De Oliveira, Roberto J. C. Fonseca, Paulo A.S. Mourão, Gustavo R.C. Santos, Isabela D. Sucupira
Publikováno v: Thrombosis and haemostasis. 117(4)
SummaryFucosylated chondroitin sulfate (FucCS) is a potent anticoagulant polysaccharide extracted from sea cucumber. Its anticoagulant activity is attributed to the presence of unique branches of sulfated fucose. Although this glycosaminoglycan exert
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a8957cf651bf740a2984f41cdb21af
https://pubmed.ncbi.nlm.nih.gov/28102426
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9
Heparin from bovine intestinal mucosa: Glycans with multiple sulfation patterns and anticoagulant effects
Autor: Stephan-Nicollas M. C. G. Oliveira, Ana M. F. Tovar, Gustavo R.C. Santos, Bruno C. Vairo, Nina V. Capillé, Paulo A.S. Mourão, Roberto J. C. Fonseca
Publikováno v: Thrombosis and Haemostasis. 107:903-915
SummaryPharmaceutical grade heparins from porcine intestine and bovine lung consist mainly of repeating tri-sulfated units, of the disaccharide →4-α-IdoA2S-1 →4-α-GlcNS6S-1 →. Heparin preparations from bovine intestine, in contrast, are more
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff94ad257e8dbd0399527ea1a555e2d4
https://doi.org/10.1160/th11-07-0518
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10
Heparins from porcine and bovine intestinal mucosa: Are they similar drugs?
Autor: Rafael S. Aquino, Gustavo R.C. Santos, Leonardo Paes Cinelli, Mariana S. Pereira, Roberto J. C. Fonseca, Bruno C. Vairo, Paulo A.S. Mourão
Publikováno v: Thrombosis and Haemostasis. 103:1005-1015
Increasing reports of bleeding and peri- or post-operative blood dyscrasias in Brazil were possibly associated with the use of heparin from bovine instead of porcine intestine. These two pharmaceutical grade heparins were analysed for potential diffe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b344869ea4462e16bbb938d9fdd61d04
https://doi.org/10.1160/th09-11-0761
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