Zobrazeno 1 - 10 of 87 pro vyhledávání: '"J C, Cambier"'
1
Syk, but not Lyn, recruitment to B cell antigen receptor and activation following stimulation of CD45- B cells
Autor: L I Pao, J C Cambier
Publikováno v: The Journal of Immunology. 158:2663-2669
B cell Ag receptor (BCR) signaling occurs via tyrosine phosphorylation of CD79a and CD79b ITAMs, leading to recruitment and activation of Lyn and Syk tyrosine kinases and subsequent downstream events. CD45 expression is required for BCR triggering of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7276420fbc11c2de52c8c6136ca9670
https://doi.org/10.4049/jimmunol.158.6.2663
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3
B cell antigen receptor cross-linking triggers rapid protein kinase C independent activation of p21ras1
Autor: A E Harwood, J C Cambier
Publikováno v: The Journal of Immunology. 151:4513-4522
Membrane Ig (mIg) functions in binding and internalization of Ag for subsequent processing and presentation to T cells, as well as in transmembrane transduction of signals that lead to cell activation, proliferation, and differentiation. Tyrosine kin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e430c397cb65741c6d7a20dcbe8ca486
https://doi.org/10.4049/jimmunol.151.9.4513
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4
The gamma subunit of the B cell antigen-receptor complex is a C-terminally truncated product of the B29 gene
Autor: R J Friedrich, K S Campbell, J C Cambier
Publikováno v: The Journal of Immunology. 150:2814-2822
The predominant Ag-receptor complex of B cells consists of mIgM or mIgD noncovalently associated with glycosylated heterodimers of Ig-alpha and Ig-beta or Ig-alpha and Ig-gamma. Upon B cell stimulation the associated proteins are phosphorylated, givi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::530f186ebf3a0100fd97ab69c65391aa
https://doi.org/10.4049/jimmunol.150.7.2814
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5
Human pre-B and B cell membrane mu-chains are noncovalently associated with a disulfide-linked complex containing a product of the B29 gene
Autor: M R Clark, R J Friedrich, K S Campbell, J C Cambier
Publikováno v: The Journal of Immunology. 149:2857-2863
B cell activation after Ag binding to membrane Ig (mIg) is mediated by a complex series of events that involves proximal activation of a tyrosine kinase and phospholipase C. Until recently it was unclear how mIgM and mIgD, with their limited cytoplas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4e708c3f912823d95e024ddb2c659eaa
https://doi.org/10.4049/jimmunol.149.9.2857
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6
Alpha-chains of IgM and IgD antigen receptor complexes are differentially N-glycosylated MB-1-related molecules
Autor: K S Campbell, E J Hager, J C Cambier
Publikováno v: The Journal of Immunology. 147:1575-1580
The major B cell Ag receptors, membrane (m) IgM and mIgD, are noncovalently associated with disulfide-linked heterodimers of alpha, beta, and gamma glycoproteins. The beta and gamma chains have apparent molecular masses of 37 and 34 kDa, respectively
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc3b763c7a7a2a2f6c0765ccd88fe4da
https://doi.org/10.4049/jimmunol.147.5.1575
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7
Transforming growth factor beta 1 has differential effects on B cell proliferation and activation antigen expression
Autor: D Cross, J C Cambier
Publikováno v: The Journal of Immunology. 144:432-439
There is accumulating evidence that TGF beta 1 is an important immunoregulatory molecule. Here we report evidence that TGF beta 1 has potent effects on murine B cells. It is profoundly inhibitory to the proliferation of quiescent B cells activated in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb4d98b4f864caa8326dc9ee03dd1985
https://doi.org/10.4049/jimmunol.144.2.432
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8
FcgammaRIIB-mediated inhibition of T-cell receptor signal transduction involves the phosphorylation of SH2-containing inositol 5-phosphatase (SHIP), dephosphorylation of the linker of activated T-cells (LAT) and inhibition of calcium mobilization
Autor: W A, Jensen, S, Marschner, V L, Ott, J C, Cambier
Publikováno v: Biochemical Society transactions. 29(Pt 6)
The low-affinity receptor for immunoglobulin G, FcgammaRIIB, is expressed on most B-cells and on immature and activated mature T-cells. Co-aggregation of FcgammaRIIB with the B-cell antigen receptor (BCR) leads to attenuation of BCR-induced blastogen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a135dd6c0708e04edda43c89bf745c3c
https://pubmed.ncbi.nlm.nih.gov/11709085
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9
Negative regulation of FcepsilonRI signaling by FcgammaRII costimulation in human blood basophils
Autor: C L, Kepley, J C, Cambier, P A, Morel, D, Lujan, E, Ortega, B S, Wilson, J M, Oliver
Publikováno v: The Journal of allergy and clinical immunology. 106(2)
Signaling through the antigen receptors of human B and T cells and the high-affinity IgE receptor FcepsilonRI of rodent mast cells is decreased by cross-linking these receptors to the low-affinity IgG receptor FcgammaRII. The inhibition is thought to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4247986098eccf403e3e60d77033c265
https://pubmed.ncbi.nlm.nih.gov/10932079
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