Zobrazeno 1 - 3
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pro vyhledávání: '"J C, Calamia"'
Autor:
J M, Fisher, S A, Wrighton, P B, Watkins, P, Schmiedlin-Ren, J C, Calamia, D D, Shen, K L, Kunze, K E, Thummel
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(2)
Cytochrome P-450 (CYP) 3A4 accounts for approximately 50% of all P-450s found in the small intestine (Paine et al., 1997) and contributes to the extensive and variable first-pass extraction of drugs such as cyclosporine and saquinavir. We recently de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e6789775d613f0dd7610a3a8071ef759
https://pubmed.ncbi.nlm.nih.gov/10215697
https://pubmed.ncbi.nlm.nih.gov/10215697
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 289(2)
It has been suggested that the binding of a drug to plasma proteins will influence the intestinal extraction efficiency when drug is delivered to the mucosal epithelium via either the gut lumen or vasculature. We evaluated this hypothesis using cytoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fabd6479349bbcc04e20255b7a97aa86
https://pubmed.ncbi.nlm.nih.gov/10215698
https://pubmed.ncbi.nlm.nih.gov/10215698
Publikováno v:
Experimental cell research. 138(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::200a1d39a3b52925619e43ad43f75ca4
https://pubmed.ncbi.nlm.nih.gov/7075693
https://pubmed.ncbi.nlm.nih.gov/7075693