Zobrazeno 1 - 8
of 8
pro vyhledávání: '"J C, Brüning"'
Autor:
C. E. Koch, K. Begemann, J. T. Kiehn, L. Griewahn, J. Mauer, M. E. Hess, A. Moser, S. M. Schmid, J. C. Brüning, H. Oster
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
In addition to promoting overconsumption, palatable diets dampen daily intake patterns, which further augments metabolic dysfunction. Here, the authors find that in mice, circadian clocks in dopaminergic neurons in the ventral tegmental area drive he
Externí odkaz:
https://doaj.org/article/66640804cce7435ea53d5a9c39a38e61
Autor:
A L, Ostermann, C M, Wunderlich, L, Schneiders, M C, Vogt, M A, Woeste, B F, Belgardt, C M, Niessen, B, Martiny, A C, Schauss, P, Frommolt, A, Nikolaev, N, Hövelmeyer, R C, Sears, P J, Koch, D, Günzel, J C, Brüning, F T, Wunderlich
Publikováno v:
Nature metabolism. 1(3)
Obesity promotes the development of insulin resistance and increases the incidence of colitis-associated cancer (CAC), but whether a blunted insulin action specifically in intestinal epithelial cells (IECs) affects CAC is unknown. Here, we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9432389c347280ac33f486246816f3b0
https://pubmed.ncbi.nlm.nih.gov/32694718
https://pubmed.ncbi.nlm.nih.gov/32694718
Publikováno v:
Deutsche medizinische Wochenschrift (1946). 134(20)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f6ac38a7b79152957ef8c9667927790b
https://pubmed.ncbi.nlm.nih.gov/19421928
https://pubmed.ncbi.nlm.nih.gov/19421928
Autor:
F. Jockenhövel, B. Allolio, F. Callies, J. C. Brüning, S. Gerhards, M. Schubert, B. Kühnert, A. Lerchl, E. Nieschlag
Publikováno v:
Männersprechstunde ISBN: 9783540009153
Im Alter sinken die Testosteronspiegel des Mannes schleichend. Bei einem nicht unerheblichen Anteil der alteren Manner fallen die Testosteronwerte in einen hypogonadalen Bereich. Dieser altersassoziierte Hypogonadismus ist von anderen Formen des Hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::920f17294bf9aed3fce7bab9bdd6c8b7
https://doi.org/10.1007/978-3-642-18705-6_2
https://doi.org/10.1007/978-3-642-18705-6_2
Publikováno v:
Journal of pediatric endocrinologymetabolism : JPEM. 13
The failure of insulin to stimulate muscle glucose uptake and suppress hepatic glucose production represents two of the fundamental pathophysiologic lesions in type 2 diabetes mellitus (DM). Defining insulin action at the molecular level, therefore,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::291cc5798973ef1316f0df609a7926c9
https://pubmed.ncbi.nlm.nih.gov/11202213
https://pubmed.ncbi.nlm.nih.gov/11202213
Publikováno v:
Medizinische Klinik (Munich, Germany : 1983). 94(10)
KNOCKOUT MICE: The generation of knockout mice has largely improved our understanding of the function of a variety of gene products. Gene inactivation experiments in mice have yielded numerous animal models for human diseases, thereby expanding our u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f0817fc4eca7f88f5e13cab0a088a17
https://pubmed.ncbi.nlm.nih.gov/10554515
https://pubmed.ncbi.nlm.nih.gov/10554515
Autor:
J. C. Brüning, David A. Clayton, C R Kahn, Caroline Graff, Nils-Göran Larsson, Hong Li, Jianming Wang, Peter Thorén, Gregory S. Barsh, Pierre Rustin, Anders Oldfors, Hans Wilhelmsson
Publikováno v:
Nature genetics. 21(1)
Mutations of mitochondrial DNA (mtDNA) cause several well-recognized human genetic syndromes with deficient oxidative phosphorylation and may also have a role in ageing and acquired diseases of old age. We report here that hallmarks of mtDNA mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2444fcfc5865f6a30e9bf6797ea92384
https://pubmed.ncbi.nlm.nih.gov/9916807
https://pubmed.ncbi.nlm.nih.gov/9916807
Autor:
J C Brüning, Rana Soylu, Deniz Kirik, B F Belgardt, J Mauer, Sofia Hult, Tomas Björklund, Åsa Petersén
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 81:A8.1-A8
Background Non-motor features of Huntington9s disease (HD) include metabolic changes such as increased appetite, insulin resistance and changes in body weight. As mutant huntingtin (htt) is ubiquitously expressed in HD as well as in most animal model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f1cce800610ce158a7ad4bbfd738d29
https://doi.org/10.1136/jnnp.2010.222570.24
https://doi.org/10.1136/jnnp.2010.222570.24