Zobrazeno 1 - 10
of 23
pro vyhledávání: '"J Brent, Kuzmiski"'
Autor:
David A. Griffith, David J. Edmonds, Jean-Philippe Fortin, Amit S. Kalgutkar, J. Brent Kuzmiski, Paula M. Loria, Aditi R. Saxena, Scott W. Bagley, Clare Buckeridge, John M. Curto, David R. Derksen, João M. Dias, Matthew C. Griffor, Seungil Han, V. Margaret Jackson, Margaret S. Landis, Daniel Lettiere, Chris Limberakis, Yuhang Liu, Alan M. Mathiowetz, Jayesh C. Patel, David W. Piotrowski, David A. Price, Roger B. Ruggeri, David A. Tess
Publikováno v:
Journal of medicinal chemistry. 65(12)
Peptide agonists of the glucagon-like peptide-1 receptor (GLP-1R) have revolutionized diabetes therapy, but their use has been limited because they require injection. Herein, we describe the discovery of the orally bioavailable, small-molecule, GLP-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff991134db369ff3aa7ceaecc2f6263e
https://pubmed.ncbi.nlm.nih.gov/35647711
https://pubmed.ncbi.nlm.nih.gov/35647711
Autor:
J. Brent Kuzmiski, João M. Dias, Seungil Han, Chris Limberakis, David Price, David J. Edmonds, John M. Curto, Amit S. Kalgutkar, Daniel J. Lettiere, David A. Tess, Clare Buckeridge, Matthew C. Griffor, David R. Derksen, Alan M. Mathiowetz, Roger B. Ruggeri, Paula M. Loria, Aditi R. Saxena, Scott W. Bagley, Yuhang Liu, Margaret S. Landis, David W. Piotrowski, V. Margaret Jackson, David A. Griffith, Jean-Phillipe Fortin
Peptide agonists of the glucagon-like peptide-1 receptor (GLP-1R) have revolutionized diabetes therapy, but their use has been limited by the requirement for injection. Here we describe the first effective, orally bioavailable small molecule GLP-1R a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::064b771366df377937229b83ffb7a9bf
https://doi.org/10.1101/2020.09.29.319483
https://doi.org/10.1101/2020.09.29.319483
Autor:
Harald Sourij, J. Brent Kuzmiski, David A. Griffith, Nicholas J. Edmunds, Ewald Kolesnik, Martin Kapl, Eva Thon-Gutschi, Senka Ljubojevic, Dirk von Lewinski, Igor Knez, Klemens Ablasser, Markus Wallner, Paulina Wakula, Mounir Khafaga, Burkert Pieske
Publikováno v:
Journal of Molecular and Cellular Cardiology. 89:365-375
Glucagon-like peptide-1 receptor (GLP-1R) agonists are a rapidly growing class of drugs developed for treating type-2 diabetes mellitus. Patients with diabetes carry an up to 5-fold greater mortality risk compared to non-diabetic patients, mainly as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77aaf97e0e256dee7ffb7918407a5a7e
https://doi.org/10.1016/j.yjmcc.2015.09.018
https://doi.org/10.1016/j.yjmcc.2015.09.018
Publikováno v:
The Journal of Physiology. 589:4259-4270
Non-technical summary The response to stress is orchestrated by parvocellular neuro- endocrine cells in the paraventricular nucleus of the hypothalamus. These cells integrate synaptic information from a number of brain regions and release hormone, ye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::526f1f43503cf36cbfab4e1ee0e7ec76
https://doi.org/10.1113/jphysiol.2011.208082
https://doi.org/10.1113/jphysiol.2011.208082
Repeated Stress Impairs Endocannabinoid Signaling in the Paraventricular Nucleus of the Hypothalamus
Publikováno v:
The Journal of Neuroscience. 30:11188-11196
Endocannabinoids (eCBs) are ubiquitous retrograde signaling molecules in the nervous system that are recruited in response to robust neuronal activity or the activation of postsynaptic G-protein-coupled receptors. Physiologically, eCBs have been impl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9a38e733cbb8d726ae8929cf2ebc1e
https://doi.org/10.1523/jneurosci.1046-10.2010
https://doi.org/10.1523/jneurosci.1046-10.2010
Autor:
Kiarash Riazi, Michael A. Galic, Winnie Ho, Keith A. Sharkey, J. Brent Kuzmiski, Quentin J. Pittman
Publikováno v:
Proceedings of the National Academy of Sciences. 105:17151-17156
Peripheral inflammation leads to a number of centrally mediated physiological and behavioral changes. The underlying mechanisms and the signaling pathways involved in these phenomena are not yet well understood. We hypothesized that peripheral inflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40b08202e2b7bfb5b107689bc9fad70
https://doi.org/10.1073/pnas.0806682105
https://doi.org/10.1073/pnas.0806682105
Autor:
Bhavik P. Shah, Jean-Philippe Fortin, Alice Liou, A. Katrina Loomis, J. Brent Kuzmiski, Philip A. Carpino, V. Margaret Jackson, Marie-Laure Rives, Danna M. Breen
Publikováno v:
Expert opinion on drug discovery. 10(8)
Obesity is a body weight disorder characterized by excess adiposity that increases the risk for developing co-morbidities such as type 2 diabetes. A large medical need exists for new anti-obesity treatments capable of promoting 10% or greater weight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90230c8b23637f9424f08e2482e8e43e
https://pubmed.ncbi.nlm.nih.gov/25967138
https://pubmed.ncbi.nlm.nih.gov/25967138
Autor:
Markus, Wallner, Ewald, Kolesnik, Klemens, Ablasser, Mounir, Khafaga, Paulina, Wakula, Senka, Ljubojevic, Eva Maria, Thon-Gutschi, Harald, Sourij, Martin, Kapl, Nicholas J, Edmunds, J Brent, Kuzmiski, David A, Griffith, Igor, Knez, Burkert, Pieske, Dirk, von Lewinski
Publikováno v:
Journal of molecular and cellular cardiology. 89
Glucagon-like peptide-1 receptor (GLP-1R) agonists are a rapidly growing class of drugs developed for treating type-2 diabetes mellitus. Patients with diabetes carry an up to 5-fold greater mortality risk compared to non-diabetic patients, mainly as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b27e0e19122cd38cf96dc6e1c200b12b
https://pubmed.ncbi.nlm.nih.gov/26432951
https://pubmed.ncbi.nlm.nih.gov/26432951
Autor:
Brian A. MacVicar, J. Brent Kuzmiski
Publikováno v:
The Journal of Neuroscience. 21:8707-8714
Plateau potentials are prolonged membrane depolarizations that are observed in hippocampal pyramidal neurons when spiking and Ca2+entry occur in combination with muscarinic receptor activation. In this study, we used whole-cell voltage clamping to st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb80891ea5c21b49e76f82558d9b816
https://doi.org/10.1523/jneurosci.21-22-08707.2001
https://doi.org/10.1523/jneurosci.21-22-08707.2001
Autor:
Jaideep S. Bains, Kimberly L. Kaminski, Arshad M. Khan, Alan G. Watts, J. Brent Kuzmiski, Todd A. Ponzio, Graciela Sanchez-Watts
Physiological responses to hypoglycemia, hyperinsulinemia, and hyperglycemia include a critical adrenocortical component that is initiated by hypothalamic control of the anterior pituitary and adrenal cortex. These adrenocortical responses ensure app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40eeec3eb6b2ea6cc7cf8f3d558acb9a
https://europepmc.org/articles/PMC3293627/
https://europepmc.org/articles/PMC3293627/