Zobrazeno 1 - 10
of 37
pro vyhledávání: '"J Brennan McNeil"'
Autor:
Jamie E Meegan, Ciara M Shaver, Nathan D Putz, Jordan J Jesse, Stuart R Landstreet, Han Noo Ri Lee, Tatiana N Sidorova, J Brennan McNeil, James L Wynn, Joyce Cheung-Flynn, Padmini Komalavilas, Colleen M Brophy, Lorraine B Ware, Julie A Bastarache
Publikováno v:
PLoS ONE, Vol 15, Iss 2, p e0228727 (2020)
Increased endothelial permeability is central to the pathogenesis of sepsis and leads to organ dysfunction and death but the endogenous mechanisms that drive increased endothelial permeability are not completely understood. We previously reported tha
Externí odkaz:
https://doaj.org/article/e068d1cb04d84396b01306e30f41f480
Autor:
J Brennan McNeil, Christopher G Hughes, Timothy Girard, Lorraine B Ware, E Wesley Ely, Rameela Chandrasekhar, Jin H Han
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226412 (2019)
BackgroundDelirium's pathophysiology is poorly understood. We sought to determine if plasma biomarkers of inflammation, coagulation, endothelial activation, and blood brain barrier (BBB) injury were associated with emergency department (ED) delirium
Externí odkaz:
https://doaj.org/article/8c5887c7cb1d430fa633d71e4b7ddff1
Autor:
Wen-Kuang Yu, J. Brennan McNeil, Nancy E. Wickersham, Ciara M. Shaver, Julie A. Bastarache, Lorraine B. Ware
Publikováno v:
Critical Care, Vol 23, Iss 1, Pp 1-9 (2019)
Abstract Background Vascular endothelial cadherin (VE-cadherin) is a membrane protein that is the major component of adherens junctions between endothelial cells. It is crucial for regulating vascular integrity, endothelial permeability, and angiogen
Externí odkaz:
https://doaj.org/article/3a19087c659c49a39cfa52932fb0c1c0
Autor:
Laura S. Murphy, Nancy Wickersham, J. Brennan McNeil, Ciara M. Shaver, Addison K. May, Julie A. Bastarache, Lorraine B. Ware
Publikováno v:
Annals of Intensive Care, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Background Disruption of the endothelial glycocalyx contributes to acute lung injury in experimental sepsis but has not been well studied in humans. To study glycocalyx degradation in sepsis-induced ARDS, we measured plasma levels of syndeca
Externí odkaz:
https://doaj.org/article/9e2e817a2dae4d258b5b1302da6be5d7
Autor:
Yue Chen, Antonio Gomez, Kevin L. Delucchi, J. Brennan McNeil, Michael A. Matthay, Nancy E. Wickersham, Carolyn S. Calfee, Kathleen D. Liu, Aleksandra Leligdowicz, Serena Ke, Kirsten N. Kangelaris, Hanjing Zhuo, Aartik Sarma, Lorraine B. Ware, Pratik Sinha, Alejandra Jauregui, Kathryn Vessel, Chunxue Wang, Jason Abbott, Carolyn M. Hendrickson
Publikováno v:
Thorax. 77:13-21
RationaleUsing latent class analysis (LCA), two subphenotypes of acute respiratory distress syndrome (ARDS) have consistently been identified in five randomised controlled trials (RCTs), with distinct biological characteristics, divergent outcomes an
Autor:
James C. Jackson, Christopher Hughes, Pratik P. Pandharipande, Jennifer L. Thompson, Onur M Orun, J. Brennan McNeil, Timothy D. Girard, Nathan E. Brummel, E. Wesley Ely, Lorraine B. Ware, Gordon R. Bernard, Rameela Raman
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 203:699-706
Rationale: The biological mechanisms of long-term cognitive impairment and disability after critical illness are unclear.Objectives: To test the hypothesis that markers of acute inflammation and coagulation are associated with subsequent long-term co
Autor:
Alicia N. Rizzo, Sarah M. Haeger, Kaori Oshima, Yimu Yang, Alison M. Wallbank, Ying Jin, Marie Lettau, Lynda A. McCaig, Nancy E. Wickersham, J. Brennan McNeil, Igor Zakharevich, Sarah A. McMurtry, Christophe J. Langouët-Astrié, Katrina W. Kopf, Dennis R. Voelker, Kirk C. Hansen, Ciara M. Shaver, V. Eric Kerchberger, Ryan A. Peterson, Wolfgang M. Kuebler, Matthias Ochs, Ruud A.W. Veldhuizen, Bradford J. Smith, Lorraine B. Ware, Julie A. Bastarache, Eric P. Schmidt
Publikováno v:
JCI Insight. 7
Acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure yet has few pharmacologic therapies, reflecting the mechanistic heterogeneity of lung injury. We hypothesized that damage to the alveolar epithelial glycocalyx, a lay
Autor:
Christopher Hughes, Frederic T. Billings, Michael R. Petracek, Ashish S. Shah, Jennifer Morse, Nancy J. Brown, J. Brennan McNeil, Anthony DeMatteo, Jason B. O’Neal, Marcos G. Lopez, Matthew S. Shotwell
Publikováno v:
Anesthesiology. 132:551-561
Background Mechanisms of postoperative delirium remain poorly understood, limiting development of effective treatments. We tested the hypothesis that intraoperative oxidative damage is associated with delirium and neuronal injury and that disruption
Autor:
Julie A. Bastarache, K.E. Jackson, Andrew J. Vincz, J. Brennan McNeil, Lorraine B. Ware, Ciara M. Shaver, Edward D. Siew, Chunxue Wang
Publikováno v:
Critical Care Explorations
Critical Care Explorations, Vol 3, Iss 9, p e0527 (2021)
Critical Care Explorations, Vol 3, Iss 9, p e0527 (2021)
Supplemental Digital Content is available in the text.
OBJECTIVES: We hypothesized that low serum albumin would contribute to pulmonary edema formation, thereby independently increasing the risk of developing acute respiratory distress syndrome
OBJECTIVES: We hypothesized that low serum albumin would contribute to pulmonary edema formation, thereby independently increasing the risk of developing acute respiratory distress syndrome
Autor:
Mark M. Wurfel, Eric D. Morrell, Catherine L. Hough, J. Brennan McNeil, Neha A. Sathe, Lorraine B. Ware, W. Conrad Liles, Carmen Mikacenic, Leila R. Zelnick, Susanna Kosamo, Pavan K. Bhatraju
Publikováno v:
Critical Care, Vol 25, Iss 1, Pp 1-11 (2021)
Critical Care
Critical Care
Background Acute hypoxemic respiratory failure (HRF) is associated with high morbidity and mortality, but its heterogeneity challenges the identification of effective therapies. Defining subphenotypes with distinct prognoses or biologic features can