Zobrazeno 1 - 10
of 1 063
pro vyhledávání: '"J Boulton"'
Autor:
Oliver J. Ziff, Jacob Neeves, Jamie Mitchell, Giulia Tyzack, Carlos Martinez-Ruiz, Raphaelle Luisier, Anob M. Chakrabarti, Nicholas McGranahan, Kevin Litchfield, Simon J. Boulton, Ammar Al-Chalabi, Gavin Kelly, Jack Humphrey, Rickie Patani
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Amyotrophic Lateral Sclerosis (ALS) causes motor neuron degeneration, with 97% of cases exhibiting TDP-43 proteinopathy. Elucidating pathomechanisms has been hampered by disease heterogeneity and difficulties accessing motor neurons. Human i
Externí odkaz:
https://doaj.org/article/dd8f26a91a1646ca8fb84eb2c02762b3
Autor:
Artur P. Kaczmarczyk, Anne-Cécile Déclais, Matthew D. Newton, Simon J. Boulton, David M. J. Lilley, David S. Rueda
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Locating a four-way junction in a high background of genomic DNA is likely to be the rate-limiting step of the resolution process. This study captures the entire reaction trajectory of a nuclease targeting and resolving a DNA junction at single-molec
Externí odkaz:
https://doaj.org/article/2dd4af52a38d41b19aa03fd0a1d451ee
Autor:
Clara Lopes Novo, Emily V. Wong, Colin Hockings, Chetan Poudel, Eleanor Sheekey, Meike Wiese, Hanneke Okkenhaug, Simon J. Boulton, Srinjan Basu, Simon Walker, Gabriele S. Kaminski Schierle, Geeta J. Narlikar, Peter J. Rugg-Gunn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Here the authors show satellite transcripts in mouse embryonic stem cells drive HP1α into droplets in vitro and also control HP1α organisation and association with chromatin in vivo. Depleting the satellite transcripts converts heterochromatin into
Externí odkaz:
https://doaj.org/article/9694c15ea6ff49a7afe36d07b4947267
Autor:
Joost Schimmel, Núria Muñoz-Subirana, Hanneke Kool, Robin van Schendel, Sven van der Vlies, Juliette A. Kamp, Femke de Vrij, Steven A. Kushner, Graeme C.M. Smith, Simon J. Boulton, Marcel Tijsterman
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112019- (2023)
Summary: Gene editing through repair of CRISPR-Cas9-induced chromosomal breaks offers a means to correct a wide range of genetic defects. Directing repair to produce desirable outcomes by modulating DNA repair pathways holds considerable promise to i
Externí odkaz:
https://doaj.org/article/2cda6fc70a1649d382e75e95931d82e5
Autor:
Joshua N. Jones, Sarah J. Boulton, Martin Stokes, Georgina L. Bennett, Michael R. Z. Whitworth
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Significant mass-wasting perturbations can be caused by 5–30 year return period extreme rainfall and by earthquake induced landscape preconditioning damage.
Externí odkaz:
https://doaj.org/article/b6fc200ec84b425dae215a17c847af67
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
A RAD51 paralog complex, RFS-1/RIP-1, is shown to control ssDNA binding and dissociation by RAD-51 differentially in the presence and absence of nucleotide cofactors. These nucleotide proofreading activities drive a preferential accumulation of RAD-5
Externí odkaz:
https://doaj.org/article/d49c4a80c40642788272abc5c212eb04
Publikováno v:
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, Vol 29, Iss 1, Pp 1-12 (2021)
Abstract Background Pre-hospital identification of major trauma in elderly patients is key for delivery of optimal care, however triage of this group is challenging. Elderly-specific triage criteria may be valuable. This systematic review aimed to su
Externí odkaz:
https://doaj.org/article/2ced54279d6549e089474701f3e0646b
Autor:
Diana Zatreanu, Helen M. R. Robinson, Omar Alkhatib, Marie Boursier, Harry Finch, Lerin Geo, Diego Grande, Vera Grinkevich, Robert A. Heald, Sophie Langdon, Jayesh Majithiya, Claire McWhirter, Niall M. B. Martin, Shaun Moore, Joana Neves, Eeson Rajendra, Marco Ranzani, Theresia Schaedler, Martin Stockley, Kimberley Wiggins, Rachel Brough, Sandhya Sridhar, Aditi Gulati, Nan Shao, Luned M. Badder, Daniela Novo, Eleanor G. Knight, Rebecca Marlow, Syed Haider, Elsa Callen, Graeme Hewitt, Joost Schimmel, Remko Prevo, Christina Alli, Amanda Ferdinand, Cameron Bell, Peter Blencowe, Chris Bot, Mathew Calder, Mark Charles, Jayne Curry, Tennyson Ekwuru, Katherine Ewings, Wojciech Krajewski, Ellen MacDonald, Hollie McCarron, Leon Pang, Chris Pedder, Laurent Rigoreau, Martin Swarbrick, Ed Wheatley, Simon Willis, Ai Ching Wong, Andre Nussenzweig, Marcel Tijsterman, Andrew Tutt, Simon J. Boulton, Geoff S. Higgins, Stephen J. Pettitt, Graeme C. M. Smith, Christopher J. Lord
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Polθ has been recently identified as a therapeutic target in cancer but specific inhibitors are currently unavailable. Here, the authors identify small molecule inhibitors of Polθ’s polymerase activity which elicit BRCA1/2 synthetic lethality, en
Externí odkaz:
https://doaj.org/article/a5462d8522964b13a5f79a9e1b35250a
Autor:
Timothy P. Lippert, Paulina Marzec, Aurora I. Idilli, Grzegorz Sarek, Aleksandra Vancevska, Mark Bower, Paul J. Farrell, Päivi M. Ojala, Niklas Feldhahn, Simon J. Boulton
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
~15% of cancers induce alternative lengthening of telomeres (ALT) to activate telomere maintenance. Here, the authors reveal that infection with Kaposi’s sarcoma herpesvirus (KSHV) induces acquisition of ALT-like features in previously non-ALT cell
Externí odkaz:
https://doaj.org/article/10dff1fa37054d0fb9e5c512d4b0b3e9
Publikováno v:
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, Vol 28, Iss 1, Pp 1-7 (2020)
Abstract Background Maintaining effective oxygenation throughout the process of Pre-Hospital Emergency Anaesthesia (PHEA) is critical. There are multiple strategies available to clinicians to oxygenate patients both prior to and during PHEA. The opti
Externí odkaz:
https://doaj.org/article/af9f02493d13420fafce90948c952bdf