Zobrazeno 1 - 10
of 990
pro vyhledávání: '"J Blackman"'
Autor:
Mark Zorman, BM BCh, MA, Paul Bamford, MB ChB, MA, MSc, Marco Coronelli, MBBS, BSc, Cara Barnes, MBBS, MPhil, Christopher Saunderson, MB ChB, MD, James Gamble, MA, MD, Sam Dawkins, BSc, DPhil, Rajesh K. Kharbanda, BSc, MB ChB, PhD, James Newton, MB ChB, MD, Adrian P. Banning, MBBS, MD, Daniel J. Blackman, MB ChB, MD, Thomas J. Cahill, MBBS, DPhil
Publikováno v:
Structural Heart, Vol 8, Iss 6, Pp 100326- (2024)
Background: Baseline right bundle branch block (RBBB) is an established predictor of permanent pacemaker (PPM) requirement after transcatheter aortic valve replacement (TAVR). There are limited data to support prophylactic PPM implantation in advance
Externí odkaz:
https://doaj.org/article/af712b642df64a5aad4d355aec20576c
Autor:
Avnish Patel, Aline Fréville, Joshua A. Rey, Helen R. Flynn, Konstantinos Koussis, Mark J. Skehel, Michael J. Blackman, David A. Baker
Publikováno v:
mBio, Vol 15, Iss 11 (2024)
ABSTRACT We previously reported that the Plasmodium falciparum putative serine/threonine protein phosphatase 7 (PP7) is a high-confidence substrate of the cAMP-dependent protein kinase (PKA). Here we explore the function of PP7 in asexual P. falcipar
Externí odkaz:
https://doaj.org/article/8e1daffe95784ff5ad6aba222b2a6941
Autor:
Suleman Aktaa, Noman Ali, Peter F Ludman, Nick Curzen, Andrew T Goodwin, David Hildick-Smith, Rajesh K Kharbanda, Peter D Jones, Sue Manuel, Satya Phanthala, Daniel J Blackman
Publikováno v:
Interventional Cardiology: Reviews, Research, Resources, Vol 19, Iss , Pp - (2024)
Background: For patients with severe aortic stenosis, transcatheter aortic valve implantation (TAVI) is a less invasive but equally effective treatment option compared with surgical aortic valve replacement (SAVR). In 2019, we reported low rates of T
Externí odkaz:
https://doaj.org/article/9b3d4cca11cc4577bb445130477fd0d1
Autor:
Konstantinos Koussis, Silvia Haase, Chrislaine Withers-Martinez, Helen R Flynn, Simone Kunzelmann, Evangelos Christodoulou, Fairouz Ibrahim, Mark Skehel, David A Baker, Michael J Blackman
Publikováno v:
PLoS Pathogens, Vol 20, Iss 6, p e1012360 (2024)
The cGMP-dependent protein kinase (PKG) is the sole cGMP sensor in malaria parasites, acting as an essential signalling hub to govern key developmental processes throughout the parasite life cycle. Despite the importance of PKG in the clinically rele
Externí odkaz:
https://doaj.org/article/b62bcb1860a84ec8b769e6b711c15964
Autor:
Michael J. Aspinwall, Chris J. Blackman, Chelsea Maier, Mark G. Tjoelker, Paul D. Rymer, Danielle Creek, Jeff Chieppa, Robert J. Griffin‐Nolan, David T. Tissue
Publikováno v:
Plant-Environment Interactions, Vol 4, Iss 2, Pp 70-85 (2023)
Abstract Aridity shapes species distributions and plant growth and function worldwide. Yet, plant traits often show complex relationships with aridity, challenging our understanding of aridity as a driver of evolutionary adaptation. We grew nine geno
Externí odkaz:
https://doaj.org/article/1afa325dd62c4f1387cf861113c35f20
Autor:
Emma Pietsch, Abhinay Ramaprasad, Sabrina Bielfeld, Yvonne Wohlfarter, Bohumil Maco, Korbinian Niedermüller, Louisa Wilcke, Joachim Kloehn, Markus A. Keller, Dominique Soldati-Favre, Michael J. Blackman, Tim-Wolf Gilberger, Paul-Christian Burda
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTPlasmodium parasites rely on a functional electron transport chain (ETC) within their mitochondrion for proliferation, and compounds targeting mitochondrial functions are validated antimalarials. Here, we localize Plasmodium falciparum patati
Externí odkaz:
https://doaj.org/article/f35cc9f369ff4e73b649d2374544ac7b
Autor:
John B Chambers, Enoch Akowuah, Daniel J Blackman, Caoimhe T Rice, Clare E Appleby, Benoy N Shah, Sophie Barnett, Shea P O'Connell
Publikováno v:
Open Heart, Vol 10, Iss 2 (2023)
Objective To assess gender, ethnicity, and deprivation-based differences in provision of aortic valve replacement (AVR) in England for adults with aortic stenosis (AS).Methods We retrospectively identified adults with AS from the English Hospital Epi
Externí odkaz:
https://doaj.org/article/22c8c560bba34b9da39cab21a25b3e2a
Autor:
Paul-Christian Burda, Abhinay Ramaprasad, Sabrina Bielfeld, Emma Pietsch, Anna Woitalla, Christoph Söhnchen, Mehar Nihal Singh, Jan Strauss, Aaron Sait, Lucy M. Collinson, Dominik Schwudke, Michael J. Blackman, Tim-Wolf Gilberger
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT For its replication within red blood cells, the malaria parasite depends on a highly active and regulated lipid metabolism. Enzymes involved in lipid metabolic processes such as phospholipases are, therefore, potential drug targets. Here, us
Externí odkaz:
https://doaj.org/article/c204e2746b334bc1a200c8924a7767df
Autor:
Liesbeth Rosseel, Darren Mylotte, Bernard Cosyns, Maarten Vanhaverbeke, David Zweiker, Rui Campante Teles, Oskar Angerås, Antoinette Neylon, Tanja Katharina Rudolph, Joanna J. Wykrzykowska, Tiffany Patterson, Giulia Costa, Soledad Ojeda, Apostolos Tzikas, Marcel Abras, Lionel Leroux, Eric Van Belle, Didier Tchétché, Sabine Bleiziffer, Martin J. Swaans, Radoslaw Parma, Daniel J. Blackman, Nicolas M. Van Mieghem, Marek Grygier, Simon Redwood, Bernard Prendergast, Guy Van Camp, Ole De Backer
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
BackgroundA steep rise in the use of transcatheter aortic valve implantation (TAVI) for the management of symptomatic severe aortic stenosis occurred. Minimalist TAVI procedures and streamlined patient pathways within experienced Heart Valve Centres
Externí odkaz:
https://doaj.org/article/fd747407a391431db5d848301cb198b2
Autor:
Abhinay Ramaprasad, Paul-Christian Burda, Konstantinos Koussis, James A Thomas, Emma Pietsch, Enrica Calvani, Steven A Howell, James I MacRae, Ambrosius P Snijders, Tim-Wolf Gilberger, Michael J Blackman
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011449 (2023)
Malaria parasite release (egress) from host red blood cells involves parasite-mediated membrane poration and rupture, thought to involve membrane-lytic effector molecules such as perforin-like proteins and/or phospholipases. With the aim of identifyi
Externí odkaz:
https://doaj.org/article/729265df578440d2850076d88548b0c4