Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation

Autor: Mikus, M.S. Kolmert, J. Andersson, L.I. Östling, J. Knowles, R.G. Gómez, C. Ericsson, M. Thörngren, J.-O. Khoonsari, P.E. Dahlén, B. Kupczyk, M. de Meulder, B. Auffray, C. Bakke, P.S. Beghe, B. Bel, E.H. Caruso, M. Chanez, P. Chawes, B. Fowler, S.J. Gaga, M. Geiser, T. Gjomarkaj, M. Horváth, I. Howarth, P.H. Johnston, S.L. Joos, G. Krug, N. Montuschi, P. Musial, J. Niżankowska-Mogilnicka, E. Olsson, H.K. Papi, A. Rabe, K.F. Sandström, T. Shaw, D.E. Siafakas, N.M. Uhlén, M. Riley, J.H. Bates, S. Middelveld, R.J.M. Wheelock, C.E. Chung, K.F. Adcock, I.M. Sterk, P.J. Djukanovic, R. Nilsson, P. Dahlén, S.-E. James, A. Ahmed, H. Balgoma, D. Bansal, A.T. Baribaud, F. Bigler, J. Billing, B. Bisgaard, H. Boedigheimer, M.J. Bønnelykke, K. Brandsma, J. Brinkman, P. Bucchioni, E. Burg, D. Bush, A. Chaiboonchoe, A. Checa, T. Compton, C.H. Corfield, J. Cunoosamy, D. D’Amico, A. Emma, R. Erpenbeck, V.J. Erzen, D. Fichtner, K. Fitch, N. Fleming, L.J. Formaggio, E. Frey, U. Gahlemann, M. Goss, V. Guo, Y.-K. Hashimoto, S. Haughney, J. Hedlin, G. Hekking, P.-P.W. Higenbottam, T. Hohlfeld, J.M. Holweg, C.T.J. Knox, A.J. Konradsen, J. Lazarinis, N. Lefaudeux, D. Li, T. Loza, M.J. Lutter, R. Manta, A. Masefield, S. Matthews, J.G. Mazein, A. Meiser, A. Miralpeix, M. Mores, N. Murray, C.S. Myles, D. Naz, S. Nordlund, B. Pahus, L. Pandis, I. Pavlidis, S. Postle, A. Powel, P. Rao, N. Reinke, S. Roberts, A. Roberts, G. Rowe, A. Schofield, J.P.R. Seibold, W. Selby, A. Sigmund, R. Singer, F. Sjödin, M. Skipp, P.J. Sousa, A.R. Sun, K. Thornton, B. Uddin, M. van Aalderen, W.M. van Geest, M. Vestbo, J. Vissing, N.H. Wagener, A.H. Wagers, S.S. Weiszhart, Z. Wheelock, C.E. Wheelock, Å. Wilson, S.J. Yasinska, V. Brusselle, G.G. Campbell, D.A. Contoli, M. Damm, K. de Rudder, I. Delin, I. Devautour, C. Duplaga, M. Eduards, M. Ek, A. Ekström, T. Figiel, E. Gaber, F. Gauw, S. Gawlewicz-Mroczka, A. Gerding, D. Haque, S. Hewitt, L. Hiemstra, P.S. Holgate, S.T. Holloway, J. Kania, A. Kanniess, F. Karlsson, Ö. Kips, J.C. Kumlin, M. Lantz, A.-S. Lazarinis, N. Magnussen, H. Mallia, P. Martling, I. Meziane, L. Oikonomidou, E. Olsson, M. Pace, E. Papadopouli, E. Papadopoulos, N. Plataki, M. Profita, M. Reinius, L.E. Richter, K. Robinson, D.S. Romagnoli, M. Samara, K. Schelfhout, V. Skedinger, M. Stamataki, E. ten Brinke, A. Vachier, I. Wallén-Nielsen, E. van Veen, I. Weersink, E. Wilson, S.J. Yasinska, V. Zervas, E. Ziolkowska-Graca, B. U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease outcome) Study Group BIOAIR (Longitudinal Assessment of Clinical Course Biomarkers in Severe Chronic Airway Disease) Consortium

Rationale Asthma phenotyping requires novel biomarker discovery. Objectives To identify plasma biomarkers associated with asthma phenotypes by application of a new proteomic panel to samples from two well-characterised cohorts of severe (SA) and mild

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::6f3a337b59e2317ed59ff73b6f19721b
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3100415

Labeling and Characterization of Human GLP-1-Secreting L-cells in Primary Ileal Organoid Culture

Autor: Frank Reimann, Rachel E. Foreman, Christopher A. Smith, Fiona M. Gribble, Van B. Lu, Emily L. Miedzybrodzka, Deborah A. Goldspink, Lawrence J. Billing, Richard G. Kay

Publikováno v: Cell Reports
Cell Reports, Vol 31, Iss 13, Pp 107833-(2020)

Summary Glucagon-like peptide-1 (GLP-1) from intestinal L-cells stimulates insulin secretion and reduces appetite after food ingestion, and it is the basis for drugs against type-2 diabetes and obesity. Drugs targeting L- and other enteroendocrine ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a59c03d7748a25d43dc5b773650b3d
http://europepmc.org/articles/PMC7342002

Labelling and Characterization of Human GLP-1 Secreting L-Cells in Primary Ileal Organoid Culture

Autor: Christopher A. Smith, Richard G. Kay, Rachel E. Foreman, Van B. Lu, Emily L. Miedzybrodzka, Deborah A. Goldspink, Lawrence J. Billing, Frank Reimann, Fiona M. Gribble

Publikováno v: SSRN Electronic Journal.

GLP-1 from intestinal L-cells stimulates insulin secretion and reduces appetite after food ingestion, and is the basis for drugs against type-2 diabetes and obesity. Drugs targeting L- and other enteroendocrine cells are under development, aiming to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70917d6f3bdd3590b4f6ab7ec4dac8b0
https://doi.org/10.2139/ssrn.3564983

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Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice – Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells

Autor: Fiona M. Gribble, Jo E. Lewis, Richard G. Kay, Pierre Larraufie, Joyce Li, Frank Reimann, Brian Y.H. Lam, Giles Sh Yeo, Deborah A. Goldspink, Andrew B. Leiter, Lawrence J. Billing

Publikováno v: Molecular metabolism
Molecular metabolism, Elsevier, 2019, 29, pp.158-169. ⟨10.1016/j.molmet.2019.09.001⟩
Molecular Metabolism, Vol 29, Iss, Pp 158-169 (2019)
Molecular Metabolism
Mol Metab

Objective Enteroendocrine cells (EECs) of the large intestine, found scattered in the epithelial layer, are known to express different hormones, with at least partial co-expression of different hormones in the same cell. Here we aimed to categorize c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03929838bfe9e606ad4f8d4ac9b73e1f
https://hal-agroparistech.archives-ouvertes.fr/hal-03450647/file/1-s2.0-S2212877819307628-main.pdf