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of 105
pro vyhledávání: '"J Bernard Heymann"'
Autor:
J Bernard Heymann
Publikováno v:
AIMS Biophysics, Vol 2, Iss 1, Pp 21-35 (2015)
Validation is a necessity to trust the structures solved by electron microscopy by single particle techniques. The impressive achievements in single particle reconstruction fuel its expansion beyond a small community of image processing experts. This
Externí odkaz:
https://doaj.org/article/db9edad6e02b464a99706384a9ad9475
Autor:
Gerard J. Kleywegt, Paul D. Adams, Sarah J. Butcher, Catherine L. Lawson, Alexis Rohou, Peter B. Rosenthal, Sriram Subramaniam, Maya Topf, Sanja Abbott, Philip R. Baldwin, John M. Berrisford, Gérard Bricogne, Preeti Choudhary, Tristan I. Croll, Radostin Danev, Sai J. Ganesan, Timothy Grant, Aleksandras Gutmanas, Richard Henderson, J. Bernard Heymann, Juha T. Huiskonen, Andrei Istrate, Takayuki Kato, Gabriel C. Lander, Shee-Mei Lok, Steven J. Ludtke, Garib N. Murshudov, Ryan Pye, Grigore D. Pintilie, Jane S. Richardson, Carsten Sachse, Osman Salih, Sjors H. W. Scheres, Gunnar F. Schroeder, Carlos Oscar S. Sorzano, Scott M. Stagg, Zhe Wang, Rangana Warshamanage, John D. Westbrook, Martyn D. Winn, Jasmine Y. Young, Stephen K. Burley, Jeffrey C. Hoch, Genji Kurisu, Kyle Morris, Ardan Patwardhan, Sameer Velankar
Publikováno v:
IUCrJ, Vol 11, Iss 2, Pp 140-151 (2024)
In January 2020, a workshop was held at EMBL-EBI (Hinxton, UK) to discuss data requirements for the deposition and validation of cryoEM structures, with a focus on single-particle analysis. The meeting was attended by 47 experts in data processing, m
Externí odkaz:
https://doaj.org/article/0e43f020fe4a4894b6f5aa6a5fd3dc2f
Autor:
J. Bernard Heymann
Publikováno v:
Viruses, Vol 15, Iss 12, p 2404 (2023)
From the first isolation of the cystovirus bacteriophage Φ6 from Pseudomonas syringae 50 years ago, we have progressed to a better understanding of the structure and transformations of many parts of the virion. The three-layered virion, encapsulatin
Externí odkaz:
https://doaj.org/article/80c406291f2c4c8b83967e9649c34ffb
Autor:
J. Bernard Heymann
Publikováno v:
Journal of Structural Biology: X, Vol 7, Iss , Pp 100083- (2023)
In our quest to solve biomolecular structures to higher resolutions in cryoEM, care must be taken to deal with all aspects of image formation in the electron microscope. One of these is the Ewald sphere/focus gradient that derives from the scattering
Externí odkaz:
https://doaj.org/article/8d41d53b8efc4808a94cd17d20854b31
Autor:
Erney Ramírez-Aportela, David Maluenda, Yunior C. Fonseca, Pablo Conesa, Roberto Marabini, J. Bernard Heymann, Jose Maria Carazo, Carlos Oscar S. Sorzano
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Here, the authors present a cryo-EM validation method for the local analysis of the map-to-model fit and introduce FSC-Q as a quality measure. FSC-Q provides a quantitative estimation of how much of the model is supported by the signal content of the
Externí odkaz:
https://doaj.org/article/b0f9ffcd38594ff8b4a765a4f399ce87
Autor:
Michael H. C. Buch, William W. Newcomb, Dennis C. Winkler, Alasdair C. Steven, J. Bernard Heymann
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
Herpes simplex virus 1 (HSV-1) infects a majority of humans, causing mostly mild disease but in some cases progressing toward life-threatening encephalitis. Understanding the life cycle of the virus is important to devise countermeasures.
Externí odkaz:
https://doaj.org/article/aa34227f2ac04187ad79ecd6912d312f
Autor:
William W. Newcomb, Juan Fontana, Dennis C. Winkler, Naiqian Cheng, J. Bernard Heymann, Alasdair C. Steven
Publikováno v:
mBio, Vol 8, Iss 3 (2017)
ABSTRACT Many viruses migrate between different cellular compartments for successive stages of assembly. The HSV-1 capsid assembles in the nucleus and then transfers into the cytoplasm. First, the capsid buds through the inner nuclear membrane, becom
Externí odkaz:
https://doaj.org/article/d721955c8359428484177c7422185897
Autor:
Anastasia A. Aksyuk, William W. Newcomb, Naiqian Cheng, Dennis C. Winkler, Juan Fontana, J. Bernard Heymann, Alasdair C. Steven
Publikováno v:
mBio, Vol 6, Iss 5 (2015)
ABSTRACT The herpes simplex virus 1 (HSV-1) capsid is a massive particle (~200 MDa; 1,250-Å diameter) with T=16 icosahedral symmetry. It initially assembles as a procapsid with ~4,000 protein subunits of 11 different kinds. The procapsid undergoes m
Externí odkaz:
https://doaj.org/article/ee0b7911acdd41b680069a561c4ef247
Publikováno v:
Progress in Retinal and Eye Research. :101147
Retinoschisin (RS1) is a secreted protein that is essential for maintaining integrity of the retina. Numerous mutations in RS1 cause X-linked retinoschisis (XLRS), a progressive degeneration of the retina that leads to vision loss in young males. A k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795157e0932cf3d2c910615677775d4d
https://doi.org/10.1016/j.preteyeres.2022.101147
https://doi.org/10.1016/j.preteyeres.2022.101147
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