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Autor:
Ando, Hideki, Sato, Tomomi, Ito, Takumi, Yamamoto, Junichi, Sakamoto, Satoshi, Nitta, Nobuhiro, Tomoko, Asatsuma-Okumura, Shimizu, Nobuyuki, Mizushima, Ryota, Aoki, Ichio, Imai, Takeshi, Yamaguchi, Yuki, J Berk, Arnold, Handa, Hiroshi, Nobuhiro, Nitta, Ichio, Aoki
Publikováno v:
iScience. 15:95-108
Thalidomide is a teratogen that causes multiple malformations in the developing baby through its interaction with cereblon (CRBN), a substrate receptor subunit of the CRL4 E3 ubiquitin ligase complex. CRBN was originally reported as a gene associated