Zobrazeno 1 - 10
of 862
pro vyhledávání: '"J Beaudoin"'
Publikováno v:
Microorganisms, Vol 11, Iss 12, p 2956 (2023)
The Guaymas Basin in the Gulf of California is characterized by active seafloor spreading, the rapid deposition of organic-rich sediments, steep geothermal gradients, and abundant methane of mixed thermogenic and microbial origin. Subsurface sediment
Externí odkaz:
https://doaj.org/article/5a5684f5ff7947fca7b83d9835e43165
Autor:
James J. Beaudoin, Kyunghee Yang, Jeffry Adiwidjaja, Guncha Taneja, Paul B. Watkins, Scott Q. Siler, Brett A. Howell, Jeffrey L. Woodhead
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Inhibition of the canalicular phospholipid floppase multidrug resistance protein 3 (MDR3) has been implicated in cholestatic drug-induced liver injury (DILI), which is clinically characterized by disrupted bile flow and damage to the biliary epitheli
Externí odkaz:
https://doaj.org/article/854fa12f4fac4c6c81044b54a6766df4
Autor:
Christopher Powers, Fatma Gomaa, Elizabeth B. Billings, Daniel R. Utter, David J. Beaudoin, Virginia P. Edgcomb, Colleen M. Hansel, Scott D. Wankel, Helena L. Filipsson, Ying Zhang, Joan M. Bernhard
Publikováno v:
Frontiers in Marine Science, Vol 9 (2022)
Certain benthic foraminifera thrive in marine sediments with low or undetectable oxygen. Potential survival avenues used by these supposedly aerobic protists include fermentation and anaerobic respiration, although details on their adaptive mechanism
Externí odkaz:
https://doaj.org/article/7b39420db4a34a809353f1e79e5437fc
Autor:
James J. Beaudoin, Lara Clemens, Mark T. Miedel, Albert Gough, Fatima Zaidi, Priya Ramamoorthy, Kari E. Wong, Rangaprasad Sarangarajan, Christina Battista, Lisl K. M. Shoda, Scott Q. Siler, D. Lansing Taylor, Brett A. Howell, Lawrence A. Vernetti, Kyunghee Yang
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9692 (2023)
Biologics address a range of unmet clinical needs, but the occurrence of biologics-induced liver injury remains a major challenge. Development of cimaglermin alfa (GGF2) was terminated due to transient elevations in serum aminotransferases and total
Externí odkaz:
https://doaj.org/article/cf333ce0b61346e283a0479af7d19b6d
Autor:
Francesco M Piccolo, Nathaniel R Kastan, Tomomi Haremaki, Qingyun Tian, Tiago L Laundos, Riccardo De Santis, Andrew J Beaudoin, Thomas S Carroll, Ji-Dung Luo, Ksenia Gnedeva, Fred Etoc, AJ Hudspeth, Ali H Brivanlou
Publikováno v:
eLife, Vol 11 (2022)
The Hippo pathway, a highly conserved signaling cascade that functions as an integrator of molecular signals and biophysical states, ultimately impinges upon the transcription coactivator Yes-associated protein 1 (YAP). Hippo-YAP signaling has been s
Externí odkaz:
https://doaj.org/article/8b46541e954746688295c6c440a4599c
Autor:
Juan Felipe Moreno Manrique, Parker R. Voit, Kathryn E. Windsor, Aamuktha R. Karla, Sierra R. Rodriguez, Gerard M. J. Beaudoin
Publikováno v:
Frontiers in Neural Circuits, Vol 15 (2021)
While electron microscopy represents the gold standard for detection of synapses, a number of limitations prevent its broad applicability. A key method for detecting synapses is immunostaining for markers of pre- and post-synaptic proteins, which can
Externí odkaz:
https://doaj.org/article/5d2d707c90384d9698ef0fcde25a54f8
Autor:
Joan M. Bernhard, Johannes C. Wit, Victoria R. Starczak, David J. Beaudoin, William G. Phalen, Daniel C. McCorkle
Publikováno v:
Frontiers in Marine Science, Vol 8 (2021)
Ocean chemistry is changing as a result of human activities. Atmospheric carbon dioxide (CO2) concentrations are increasing, causing an increase in oceanic pCO2 that drives a decrease in oceanic pH, a process called ocean acidification (OA). Higher C
Externí odkaz:
https://doaj.org/article/2d212141d7fd4c849af814d81af7bb14
Autor:
Étienne J. Beaudoin, Maurício M. Kubaski, Mazen Samara, Ricardo J. Zednik, Nicole R. Demarquette
Publikováno v:
Nanomaterials, Vol 12, Iss 8, p 1356 (2022)
Electrospinning has gained much attention in recent years due to its ability to easily produce high-quality polymeric nanofibers. However, electrospinning suffers from limited production capacity and a method to readily scale up this process is neede
Externí odkaz:
https://doaj.org/article/5ff36db2bc6e4c908c05e6a9e938936c
Autor:
Yang, James J. Beaudoin, Lara Clemens, Mark T. Miedel, Albert Gough, Fatima Zaidi, Priya Ramamoorthy, Kari E. Wong, Rangaprasad Sarangarajan, Christina Battista, Lisl K. M. Shoda, Scott Q. Siler, D. Lansing Taylor, Brett A. Howell, Lawrence A. Vernetti, Kyunghee
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 11; Pages: 9692
Biologics address a range of unmet clinical needs, but the occurrence of biologics-induced liver injury remains a major challenge. Development of cimaglermin alfa (GGF2) was terminated due to transient elevations in serum aminotransferases and total
Autor:
William A. Murphy, Jeffry Adiwidjaja, Noora Sjöstedt, Kyunghee Yang, James J. Beaudoin, Jessica Spires, Scott Q. Siler, Sibylle Neuhoff, Kim L.R. Brouwer
Publikováno v:
Clinical Pharmacology & Therapeutics. 113:275-297
Nonalcoholic fatty liver disease (NAFLD), representing a clinical spectrum ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), is rapidly evolving into a global pandemic. Patients with NAFLD are burdened with high rat