Zobrazeno 1 - 10 of 61 pro vyhledávání: '"J Bart A Crusius"'
1
Akademický článek
TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits.
Autor: Dorothée Diogo, Lisa Bastarache, Katherine P Liao, Robert R Graham, Robert S Fulton, Jeffrey D Greenberg, Steve Eyre, John Bowes, Jing Cui, Annette Lee, Dimitrios A Pappas, Joel M Kremer, Anne Barton, Marieke J H Coenen, Barbara Franke, Lambertus A Kiemeney, Xavier Mariette, Corrine Richard-Miceli, Helena Canhão, João E Fonseca, Niek de Vries, Paul P Tak, J Bart A Crusius, Michael T Nurmohamed, Fina Kurreeman, Ted R Mikuls, Yukinori Okada, Eli A Stahl, David E Larson, Tracie L Deluca, Michelle O'Laughlin, Catrina C Fronick, Lucinda L Fulton, Roman Kosoy, Michael Ransom, Tushar R Bhangale, Ward Ortmann, Andrew Cagan, Vivian Gainer, Elizabeth W Karlson, Isaac Kohane, Shawn N Murphy, Javier Martin, Alexandra Zhernakova, Lars Klareskog, Leonid Padyukov, Jane Worthington, Elaine R Mardis, Michael F Seldin, Peter K Gregersen, Timothy Behrens, Soumya Raychaudhuri, Joshua C Denny, Robert M Plenge
Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0122271 (2015)
Despite the success of genome-wide association studies (GWAS) in detecting a large number of loci for complex phenotypes such as rheumatoid arthritis (RA) susceptibility, the lack of information on the causal genes leaves important challenges to inte
Externí odkaz: https://doaj.org/article/beb6d79c3e184701a89299ca92e0df4f
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2
Akademický článek
Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis.
Autor: Jing Cui, Eli A Stahl, Saedis Saevarsdottir, Corinne Miceli, Dorothee Diogo, Gosia Trynka, Towfique Raj, Maša Umiċeviċ Mirkov, Helena Canhao, Katsunori Ikari, Chikashi Terao, Yukinori Okada, Sara Wedrén, Johan Askling, Hisashi Yamanaka, Shigeki Momohara, Atsuo Taniguchi, Koichiro Ohmura, Fumihiko Matsuda, Tsuneyo Mimori, Namrata Gupta, Manik Kuchroo, Ann W Morgan, John D Isaacs, Anthony G Wilson, Kimme L Hyrich, Marieke Herenius, Marieke E Doorenspleet, Paul-Peter Tak, J Bart A Crusius, Irene E van der Horst-Bruinsma, Gert Jan Wolbink, Piet L C M van Riel, Mart van de Laar, Henk-Jan Guchelaar, Nancy A Shadick, Cornelia F Allaart, Tom W J Huizinga, Rene E M Toes, Robert P Kimberly, S Louis Bridges, Lindsey A Criswell, Larry W Moreland, João Eurico Fonseca, Niek de Vries, Barbara E Stranger, Philip L De Jager, Soumya Raychaudhuri, Michael E Weinblatt, Peter K Gregersen, Xavier Mariette, Anne Barton, Leonid Padyukov, Marieke J H Coenen, Elizabeth W Karlson, Robert M Plenge
Publikováno v: PLoS Genetics, Vol 9, Iss 3, p e1003394 (2013)
Anti-tumor necrosis factor alpha (anti-TNF) biologic therapy is a widely used treatment for rheumatoid arthritis (RA). It is unknown why some RA patients fail to respond adequately to anti-TNF therapy, which limits the development of clinical biomark
Externí odkaz: https://doaj.org/article/81c1f31b39334e34b1f84c06c37997b4
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3
Akademický článek
Farnesoid X receptor (FXR) activation and FXR genetic variation in inflammatory bowel disease.
Autor: Rian M Nijmeijer, Raffaella M Gadaleta, Saskia W C van Mil, Adriaan A van Bodegraven, J Bart A Crusius, Gerard Dijkstra, Daan W Hommes, Dirk J de Jong, Pieter C F Stokkers, Hein W Verspaget, Rinse K Weersma, C Janneke van der Woude, Janneke M Stapelbroek, Marguerite E I Schipper, Cisca Wijmenga, Karel J van Erpecum, Bas Oldenburg, Dutch Initiative on Crohn, Colitis (ICC)
Publikováno v: PLoS ONE, Vol 6, Iss 8, p e23745 (2011)
BACKGROUND: We previously showed that activation of the bile salt nuclear receptor Farnesoid X Receptor (FXR) protects against intestinal inflammation in mice. Reciprocally, these inflammatory mediators may decrease FXR activation. We investigated wh
Externí odkaz: https://doaj.org/article/05b63e3277914878bd5bbc5b4a1acf88
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4
Akademický článek
Genetic association analysis of the functional c.714T>G polymorphism and mucosal expression of dectin-1 in inflammatory bowel disease.
Autor: Hilbert S de Vries, Theo S Plantinga, J Han van Krieken, Rinke Stienstra, Ad A van Bodegraven, Eleonora A M Festen, Rinse K Weersma, J Bart A Crusius, Ronald K Linskens, Leo A B Joosten, Mihai G Netea, Dirk J de Jong
Publikováno v: PLoS ONE, Vol 4, Iss 11, p e7818 (2009)
BACKGROUND: Dectin-1 is a pattern recognition receptor (PRR) expressed by myeloid cells that specifically recognizes beta-1,3 glucan, a polysaccharide and major component of the fungal cell wall. Upon activation, dectin-1 signaling converges, similar
Externí odkaz: https://doaj.org/article/630c70dd74b4434aabe728e773b2c2e9
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5
Akademický článek
Effective detection of human leukocyte antigen risk alleles in celiac disease using tag single nucleotide polymorphisms.
Autor: Alienke J Monsuur, Paul I W de Bakker, Alexandra Zhernakova, Dalila Pinto, Willem Verduijn, Jihane Romanos, Renata Auricchio, Ana Lopez, David A van Heel, J Bart A Crusius, Cisca Wijmenga
Publikováno v: PLoS ONE, Vol 3, Iss 5, p e2270 (2008)
BACKGROUND: The HLA genes, located in the MHC region on chromosome 6p21.3, play an important role in many autoimmune disorders, such as celiac disease (CD), type 1 diabetes (T1D), rheumatoid arthritis, multiple sclerosis, psoriasis and others. Known
Externí odkaz: https://doaj.org/article/a522fc8e64f040e691cd1a3777a6e924
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9
Association of FcgR2a, but not FcgR3a, with inflammatory bowel diseases across three Caucasian populations†
Autor: Colin L. Noble, Roel Heijmans, Tony R. Merriman, J. Bart A. Crusius, Javier Martin, A. Salvador Peña, Jade E Hollis-Moffatt, Eleonora A. M. Festen, Simone C. Wolfkamp, Rogelio Palomino-Morales, Antonio Nieto, Rebecca L. Roberts, María Gómez-García, Richard B. Gearry, Cisca Wijmenga, Bobby P. C. Koeleman, Rinse K. Weersma, Adriaan A. van Bodegraven, Murrary L. Barclay, Timothy R D J Radstake, Luis Rodrigo, Pieter C. F. Stokkers, Miguel A. López-Nevot, Behrooz Z. Alizadeh, Sander Meisneris
Publikováno v: Weersma, R K, Crusius, J B A, Roberts, R L, Koeleman, B P C, Palomino-Morales, R, Wolfkamp, S, Hollis-Moffatt, J E, Festen, E A M, Meisneris, S, Heijmans, R, Noble, C L, Gearry, R B, Barclay, M L, Gomez-Garcia, M, Lopez-Nevot, M A, Nieto, A, Rodrigo, L, Radstake, T R D J, van Bodegraven, A A, Wijmenga, C, Merriman, T R, Stokkers, P C F, Pena, A S, Martin, J & Alizadeh, BZ 2010, ' Association of FcgR2a, but Not FcgR3a, with Inflammatory Bowel Diseases Across Three Caucasian Populations ', Inflammatory Bowel Diseases, vol. 16, no. 12, pp. 2080-2089 . https://doi.org/10.1002/ibd.21342
Inflammatory bowel diseases, 16(12), 2080-2089. John Wiley and Sons Inc.
Inflammatory Bowel Diseases, 16(12), 2080-2089. John Wiley and Sons Inc.
Inflammatory Bowel Diseases, 16(12), 2080-2089. LIPPINCOTT WILLIAMS & WILKINS
Inflammatory Bowel Diseases, 16, 2080-9
Inflammatory Bowel Diseases, 16, 12, pp. 2080-9
Item does not contain fulltext BACKGROUND: The Fc receptors II and III (FcgR2a, and FcgR3a) play a crucial role in the regulation of the immune response. The FcgR2a*519GG and FcgR3a*559CC genotypes have been associated with several autoimmune disease
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7799750090dc03865b342c0bb8cbdda
https://doi.org/10.1002/ibd.21342
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10
Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease
Autor: Karin Fransen, Jinyuan Y. Fu, Adriaan A. van Bodegraven, Pieter Zanen, Daniel W. Hommes, J. Bart A. Crusius, Cleo C. van Diemen, Eleonora A. M. Festen, Rinse K. Weersma, Marijn C. Visschedijk, Cisca Wijmenga, Suzanne van Sommeren, Pieter C. F. Stokkers, Dirk J. de Jong, Lude Franke
Publikováno v: Human Molecular Genetics, 19, 3482-8
Human Molecular Genetics, 19(17), 3482-3488. Oxford University Press
Human molecular genetics, 19(17), 3482-3488. Oxford University Press
Fransen, K, Visschedijk, M C, van Sommeren, S, Fu, J Y Y, Franke, L, Festen, E A M, Stokkers, P C F, van Bodegraven, A A, Crusius, J B A, Hommes, D W, Zanen, P, Jong, D J, Wijmenga, C, van Diemen, C C & Weersma, R K 2010, ' Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease ', Human Molecular Genetics, vol. 19, no. 17, pp. 3482-3488 . https://doi.org/10.1093/hmg/ddq264
Human Molecular Genetics, 19(17), 3482-3488
Human Molecular Genetics, 19, 17, pp. 3482-8
Item does not contain fulltext Genome-wide association studies (GWAS) for Crohn's disease (CD) have identified loci explaining approximately 20% of the total genetic risk of CD. Part of the other genetic risk loci is probably partly hidden among sign
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47edca651561c77736d7c17efa585adc
https://research.rug.nl/en/publications/ee6e6e61-7b70-4f4a-acb4-d817c5a18421
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