Zobrazeno 1 - 10
of 544
pro vyhledávání: '"J Bajgar"'
Autor:
J. Bajgar, L. Bartosova
Publikováno v:
Current Medicinal Chemistry. 19:4671-4677
The assessment of percutaneous absorption of molecules is a very important step in the evaluation of any dermal or transdermal drug delivery system. In order to perform percutaneous drug absorption studies, it is essential that the methods are standa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b3268aa63a8503bae4b8af84fb2ca8
https://doi.org/10.2174/092986712803306358
https://doi.org/10.2174/092986712803306358
Autor:
L Bartosova-Sevelova, J Bajgar
Publikováno v:
Human & Experimental Toxicology. 24:363-367
In our study, rats were exposed to sarin vapors for 240 min at four different concentrations (0.30, 0.43, 0.58 and 0.82 mg/L) in a whole-body inhalation chamber. The acetylcholinesterase activity (AChE, EC 3.1.1.7) was measured in the whole blood, fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3762d80863acb465f22c867867d7c3c5
https://doi.org/10.1191/0960327105ht539oa
https://doi.org/10.1191/0960327105ht539oa
Publikováno v:
Toxicology in Vitro. 13:403-408
Guinea pig and rabbit erythrocytes were incubated with a high concentration of soman to achieve zero acetylcholinesterase activity. After washing with saline, the erythrocytes were incubated with horse plasma butyrylcholinesterase. The inhibition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657a4eb3dc19cb9ecd183f9c640b1663
https://doi.org/10.1016/s0887-2333(99)00009-0
https://doi.org/10.1016/s0887-2333(99)00009-0
Publikováno v:
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti. 54(4)
The nerve agent tabun inhibits acetylcholinesterase (AChE; EC 3.1.1.7) by the formation of a covalent bond with the enzyme. Afterwards, AChE is not able to fulfil its role in the organism and subsequently cholinergic crisis occurs. AChE reactivators
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b926473df1fd07f367c75430c69d44a6
https://pubmed.ncbi.nlm.nih.gov/16124202
https://pubmed.ncbi.nlm.nih.gov/16124202
Publikováno v:
Central European journal of public health.
In our study we monitored plasmatic levels of sarin and changes in cholinesterase activities in rats after exposure to sarin vapors at low concentration. Rats were exposed to sarin in inhalation chamber at concentration 1.25 or 2.5 microg/l for 60 mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::96c11c6f58125b81c7efbee8d7f4f140
https://pubmed.ncbi.nlm.nih.gov/15141989
https://pubmed.ncbi.nlm.nih.gov/15141989
Publikováno v:
General physiology and biophysics. 18(4)
Changes in cholinesterases activities in daunorubicin cardiomyopathy and in dexrazoxane (DRZX)-treated daunorubicin cardiomyopathy were investigated in rabbits. Acetyl- and butyrylcholinesterase (AChE and BuChE) were determined using Ellman's method.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7ab9bf71d9364c0c9d5fbcc68cc8f198
https://pubmed.ncbi.nlm.nih.gov/10766032
https://pubmed.ncbi.nlm.nih.gov/10766032
Publikováno v:
General physiology and biophysics.
Changes of choline acetyltransferase (ChAT) activity in the hippocampus and the basal ganglia were studied in rats treated i.p. with L-carnitine (CRT) and 7-methoxytacrine (7-MEOTA) (i.m.) separately or 3-days treated with L-carnitine and then with o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f27458e520cd60fe4d7aefaa2f6a6150
https://pubmed.ncbi.nlm.nih.gov/10703712
https://pubmed.ncbi.nlm.nih.gov/10703712
Publikováno v:
Casopis lekaru ceskych. 138(17)
Acute poisoning with the highly toxic organophosphorus agent, soman, is not treated satisfactorily even by the most modern antidotes.In experiments on rats, the reactivating effect of a new asymmetric bispyridinium oxime BI-6 was compared with widely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb953a07a8d741b436524c9430c4b16c
https://pubmed.ncbi.nlm.nih.gov/10566233
https://pubmed.ncbi.nlm.nih.gov/10566233
Autor:
V, Gersl, R, Hrdina, J, Vávrová, M, Holecková, V, Palicka, J, Voglová, Y, Mazurová, J, Bajgar
Publikováno v:
Acta medica (Hradec Kralove). 40(1)
The effects of weekly intravenously administered a dithiol chelating agent-sodium 2,3-dimercaptopropane-sulphonate (DMPS)-in a single dose of 50 mg/kg/week for 10 weeks on biochemical and haematological parameters were studied in rabbits. DMPS was we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::41ebb029f32223d019d2de2c06f006fa
https://pubmed.ncbi.nlm.nih.gov/9329207
https://pubmed.ncbi.nlm.nih.gov/9329207