Výsledky vyhledávání - "J B van Bree"

PHARMACOKINETICS AND TOLERABILITY OF A MICROEMULSION FORMULATION OF CYCLOSPORINE IN RENAL ALLOGRAFT RECIPIENTS—A CONCENTRATION-CONTROLLED COMPARISON WITH THE COMMERCIAL FORMULATION

Autor: K Kutz, J B van Bree, John M. Kovarik, E A Mueller, Arno Lison

Publikováno v: Transplantation. 57:1178-1182

The steady-state pharmacokinetics and tolerability of a microemulsion formulation of cyclosporine (Sandimmune Neoral) were compared with Sandimmune in 18 clinically stable renal allograft recipients. In study period I (2 weeks duration), patients ent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0893aef8c95945533828b576ceab453
https://doi.org/10.1097/00007890-199404270-00007

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[Untitled]

Autor: P. W. Lücker, John M. Kovarik, E A Mueller, K Kutz, J B van Bree, J Grevel

Publikováno v: Pharmaceutical Research. 11:151-155

The influence of a fat-rich meal on the pharmacokinetics of cyclosporine from a new oral formulation (Sandimmune Neoral) was compared in a randomized, four-way crossover study to the currently marketed formulation (Sandimmune) in 24 healthy male volu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::396022f8dd17a6010fd9f31d925d33ce
https://doi.org/10.1023/a:1018922517162

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[Untitled]

Autor: E A Mueller, J B van Bree, K Kutz, John M. Kovarik, J Grevel, Wolfgang Tetzloff

Publikováno v: Pharmaceutical Research. 11:301-304

The pharmacokinetic dose proportionality and relative bioavailability of cyclosporine from a microemulsion formulation (Sandimmune Neoral) were compared to those of the commercial formulation (Sandimmune) over the dosage range 200 to 800 mg. Single o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33d962325ea6706a10c46b0028243d49
https://doi.org/10.1023/a:1018923912135

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Improved dose linearity of cyclosporine pharmacokinetics from a microemulsion formulation

Autor: E A, Mueller, J M, Kovarik, J B, van Bree, W, Tetzloff, J, Grevel, K, Kutz

Publikováno v: Pharmaceutical research. 11(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::45df0d41c37bf4bea02ae26964349b39
https://pubmed.ncbi.nlm.nih.gov/8165192

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Influence of a fat-rich meal on the pharmacokinetics of a new oral formulation of cyclosporine in a crossover comparison with the market formulation

Autor: E A, Mueller, J M, Kovarik, J B, van Bree, J, Grevel, P W, Lücker, K, Kutz

Publikováno v: Pharmaceutical research. 11(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a11bb50214795c54e9d5357c08b2b84c
https://pubmed.ncbi.nlm.nih.gov/8140046

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Stereoselective transport of baclofen across the blood-brain barrier in rats as determined by the unit impulse response methodology

Autor: J B, van Bree, C D, Heijligers-Feijen, A G, de Boer, M, Danhof, D D, Breimer

Publikováno v: Pharmaceutical research. 8(2)

The blood-brain barrier transport characteristics of racemic baclofen and the separate R- and S-enantiomers have been determined in vivo in rats by using the unit impulse response methodology. Transport rate was determined as blood-brain barrier clea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e21b482d5e0ebdd4e5a5e36e13a22395
https://pubmed.ncbi.nlm.nih.gov/2023878

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Transport of desglycinamide-arginine vasopressin across the blood-brain barrier in rats as evaluated by the unit impulse response methodology

Autor: J B, van Bree, S, Tio, A G, de Boer, M, Danhof, J C, Verhoef, D D, Breimer

Publikováno v: Pharmaceutical research. 7(3)

The pharmacokinetic characteristics of desglycinamide-arginine vasopressin (DGAVP) with respect to its transport across the blood-brain barrier (BBB) were studied with the use of serial CSF sampling in an individual animal and the unit impulse respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1aff6dd400c795d6605bb02d1140db6a
https://pubmed.ncbi.nlm.nih.gov/2339105

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CYCLOSPORINE PHARMACOKINETICS AND VARIABILITY FROM A MICROEMULSION FORMULATION—A MULTICENTER INVESTIGATION IN KIDNEY TRANSPLANT PATIENTS

Autor: W H Boesken, Arno Lison, H Lange, John M. Kovarik, E A Mueller, B Schmidt, S S Flückiger, K Kutz, J B van Bree

Publikováno v: Transplantation. 58:663

The steady-state pharmacokinetics and tolerability of a microemulsion formulation of cyclosporine (Sandimmune Neoral) were compared with the commercial formulation (Sandimmune) in 55 clinically stable renal allograft recipients. In study period I (2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::355ff7d8642eaa4521efd3cf90dfe643
https://doi.org/10.1097/00007890-199409000-00004

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